A5103158676- Angiogenesis and VEGF in Cancer
- Cancer, Hypoxia, and Metabolism
- Antiplatelet Therapy and Cardiovascular Diseases
- Biochemical Acid Research Studies
- Platelet Disorders and Treatments
- Macrophage Migration Inhibitory Factor
- Heme Oxygenase-1 and Carbon Monoxide
- Pharmacology and Obesity Treatment
- Magnolia and Illicium research
- Apelin-related biomedical research
- Peroxisome Proliferator-Activated Receptors
- Diabetes Treatment and Management
- Phosphodiesterase function and regulation
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Pregnancy and preeclampsia studies
- Histone Deacetylase Inhibitors Research
- Seaweed-derived Bioactive Compounds
- Cancer, Lipids, and Metabolism
- Protein Kinase Regulation and GTPase Signaling
- Nutrition and Health in Aging
- Therapeutic Uses of Natural Elements
- Chemotherapy-induced cardiotoxicity and mitigation
- Receptor Mechanisms and Signaling
- Aldose Reductase and Taurine
- Sesquiterpenes and Asteraceae Studies
National Defense Medical Center
1991-2022
China Medical University Hospital
2013-2022
China Medical University
2013-2022
Asia University
2013-2022
Cathay General Hospital
2020-2022
Taipei Tzu Chi Hospital
2018-2019
Tzu Chi University
2013-2017
National Taiwan Normal University
2000
Tri-Service General Hospital
1991-1998
Activation of hypoxia-induced hypoxia-inducible factors-1 (HIF-1) plays a critical role in promoting tumor angiogenesis, growth and metastasis. Low molecular weight fucoidan (LMWF) is prepared from brown algae, exhibits anticancer activity. However, whether LMWF attenuates angiogenesis bladder cancer cells the mechanisms involved remain unclear. This first study to demonstrate that can inhibit hypoxia-stimulated H2O2 formation, HIF-1 accumulation transcriptional activity vascular endothelial...
Cancer cachexia is characterized by anorexia, skeletal muscle atrophy, and systemic inflammation. Fucoidan extracted from brown algae exhibits anti-inflammatory anticancer activities. However, whether fucoidan ameliorates tumour chemotherapy-induced atrophy -related cachectic symptoms remains unknown. Compared with mice bladder cancer treated chemotherapy alone (TGC group), those a combination of low molecular weight (LMWF) drugs such as gemcitabine cisplatin (TGCF) showed significant...
Fucoidan extracted from brown algae has multiple beneficial functions. In this study, we investigated the effects of low-molecular-weight fucoidan (oligo-FO) on renal fibrosis under in vitro and vivo diabetic conditions, its molecular mechanisms. Advanced glycation product (AGE)-stimulated rat proximal tubular epithelial cells (NRK-52E) mice induced by high-fat diet intraperitoneal injection streptozotocin nicotinamide were used. Oligo-FO treatment significantly inhibited anti-high mobility...
Skeletal muscle atrophy, the most prominent phenotypic feature of cancer cachexia, is often observed in patients undergoing chemotherapy. Magnolol (M) extracted from Magnolia officinalis exhibits several pharmacological effects including anti-inflammatory and anticancer activities. In this study, we investigated whether magnolol supplementation protects against development cachexia symptoms bladder cancer-bearing mice Combined treatment with chemotherapeutic drugs, such as gemcitabine...
Scope Several beneficial biological functions of fucoidan (FO) isolated from brown algae have been demonstrated. The purpose this study was to investigate whether FO derived Sargassum hemiphyllum ameliorates pancreatic β‐cell damage and impaired insulin synthesis under diabetic condition. Methods results effects were studied in streptozotocin (STZ)‐treated line, NIT‐1cells, mice. cell apoptosis, protein analyses, histological examination, function assays performed. increased apoptosis...
Abstract The accumulation of advanced glycation end products (AGEs) in diabetic patients induces vascular endothelial injury. Promyelocytic leukemia zinc finger protein (PLZF) is a transcription factor that can be activated by low-temperature far-infrared (FIR) irradiation to exert beneficial effects on the endothelium. In present study, we investigated influence FIR-induced PLZF activation AGE-induced injury both vitro and vivo . FIR inhibited apoptosis human umbilical vein cells (HUVECs)....
Abstract The hypoxia-inducible factor-1α (HIF-1α) plays a critical role in tumor angiogenesis. It has been reported that the acetone extract of Angelica sinensis (AE-AS) rich phthalides is able to inhibit cancer cell proliferation. However, whether AE-AS reduces angiogenesis remains unknown. In this study, we demonstrated significantly inhibited vitro and vivo evidenced by attenuation tube formation hypoxic human umbilical vascular endothelial cells (HUVECs), vasculature generation Matrigel...
Peroxisome proliferator-activated receptors (PPARs) isoforms (α, β/δ, and γ are present in human platelets, activation of PPARs inhibits platelet aggregation. α-Lipoic acid (ALA), occurring naturally food, has been reported to exhibit an antiplatelet activity. However, the mechanisms underlying ALA-mediated inhibition aggregation remain unknown. The aim this study was investigate whether activity ALA is mediated by PPARs. itself significantly induced PPARα/γ platelets increased intracellular...
α-Lipoic acid (ALA) is often used as a dietary supplement to prevent and treat chronic diseases associated with excessive oxidative stress. The aim of this study was investigate the mechanisms antiplatelet activity ALA. ALA significantly inhibited collagen-induced platelet aggregation, thromboxane B2 (TXB2) formation, Ca2+ mobilization, protein kinase Cα (PKCα) activation, but itself increased cyclic AMP formation in rabbit washed platelets. However, effects on above responses were markedly...
Baicalein (BE) extracted from Scutellaria baicalensis Georgi is able to alleviate various cardiovascular and inflammatory diseases. However, the effects of BE on pulmonary arterial hypertension (PAH) remain unknown. Therefore, present study aimed examine whether ameliorates pneumonectomy monocrotaline-induced PAH in rats further investigate underlying molecular mechanisms. Administration greatly attenuated development as evidenced by an improvement its characteristic features, including...
Platelet hyperactivity often occursd in hypertensive patients and is a key factor the development of cardiovascular diseases including thrombosis atherosclerosis. Nifedipine, an L-type calcium channel blocker, widely used for hypertension coronary heart disease therapy. In addition, nifedipine known to exhibit antiplatelet activity, but underlying mechanisms involved remain unclear. Several transcription factors such as peroxisome proliferator-activated receptors (PPARs) nuclear kappa B...
Severe vascular damage and complications are often observed in cancer patients during treatment with chemotherapeutic drugs such as cisplatin. Thus, development of potential options to ameliorate the side effects is urgently needed. In this study, underlying mechanisms far-infrared radiation (FIR) on cisplatin-induced injury endothelial cytotoxicity/dysfunction mice human umbilical vein cells (HUVECs) were investigated. An important finding that severe stenosis poor blood flow seen...
The transcription factor NF-κB, stimulates platelet aggregation through a non-genomic mechanism. Nifedipine, voltage-gated L-type calcium channel blocker, is widely used to treat hypertension. Nifedipine also displays antiplatelet activity, but the underlying mechanisms involved remain unclear. This study was designed investigate whether effects of nifedipine are mediated by regulating NF-κB-dependent responses.Platelet measured turbidimetrically using an aggregometer. NF-κB and PPAR...
Objective: In the present study, we investigated effects of dextromethorphan (DM) and its metabolites, including dextrorphan (LK2), 3-methoxymorphinan (LK3), 3-hydroxymorphinan (LK4), on platelet aggregation in vitro inflammatory pain caused by carrageenan rats, their underlying mechanisms.Materials Methods: Rabbit platelets were pretreated with DM or metabolites to assess related target mediators.In addition, analgesic activity mechanisms LK3 a carrageenan-evoked thermal hyperalgesia rat...