A5022025798- Marine Sponges and Natural Products
- Coral and Marine Ecosystems Studies
- Aquaculture disease management and microbiota
- Forensic Anthropology and Bioarchaeology Studies
- Forensic and Genetic Research
- Cardiovascular Disease and Adiposity
- Yersinia bacterium, plague, ectoparasites research
- Extracellular vesicles in disease
- Parasitic Infections and Diagnostics
- Marine and coastal plant biology
- Salmonella and Campylobacter epidemiology
- Child Nutrition and Water Access
- Archaeology and ancient environmental studies
- Evolutionary Psychology and Human Behavior
- Insect Pest Control Strategies
- Genetic diversity and population structure
- Vibrio bacteria research studies
- Echinoderm biology and ecology
- Protist diversity and phylogeny
- Oral microbiology and periodontitis research
- Insect symbiosis and bacterial influences
- Marine Invertebrate Physiology and Ecology
- Invertebrate Immune Response Mechanisms
- Hormonal Regulation and Hypertension
- Pediatric health and respiratory diseases
Boston University
2021-2024
Pontificia Universidad Católica de Chile
2023-2024
Google (United States)
2024
Institut de Biologia Evolutiva
2021-2023
Universitat Pompeu Fabra
2021-2023
Universitat de València
2019
Pontificia Universidad Católica del Ecuador
1995
Central University of Ecuador
1995
Ministerio de Salud Pública
1995
The rise and fall of the Roman Empire was a socio-political process with enormous ramifications for human history. Middle Danube crucial frontier crossroads population cultural movement. Here, we present genome-wide data from 136 Balkan individuals dated to 1
Mutualistic symbioses between cnidarians and photosynthetic algae are modulated by complex interactions host immunity environmental conditions. Here, we investigate how symbiosis interacts with food limitation to influence gene expression stress response programming in the sea anemone Exaiptasia pallida (Aiptasia). Transcriptomic responses starvation were similar symbiotic aposymbiotic Aiptasia; however, stronger. Starved Aiptasia of both states exhibited increased protein levels...
The human face is one of the most visible features our unique identity as individuals. Interestingly, monozygotic twins share almost identical facial traits and same DNA sequence but could exhibit differences in other biometrical parameters. expansion world wide web possibility to exchange pictures humans across planet has increased number people identified online virtual or doubles that are not family related. Herein, we have characterized detail a set "look-alike" humans, defined by...
Abstract Lack of proper nutrition has important consequences for the physiology all organisms, and nutritional status can affect immunity, based on many studies in terrestrial animals. Here we show a positive correlation between immunity sea anemone Nematostella vectensis . Gene expression profiling adult anemones shows downregulation genes involved nutrient metabolism, cellular respiration, starved Starved also have reduced protein levels activity transcription factor NF-κB. juvenile...
Abstract Mutualistic symbioses between cnidarians and photosynthetic algae are modulated by complex interactions host immunity environmental conditions. Here, we investigate how symbiosis interacts with nutrient limitation to influence gene expression stress response programming in the sea anemone Exaiptasia pallida (Aiptasia). Transcriptomic responses starvation were similar symbiotic aposymbiotic Aiptasia; however, stronger. Starved Aiptasia of both states exhibited increased protein...
To determine the risk for diarrheal disease (DD) in day-care centers (DCC) children residing a poor urban slum area of Quito, Ecuador, compared with that from same environment but cared their own residential home (RH), prospective age-, sex- and locale-controlled study DD was conducted, including 115 DCC RH, ages 12 to 42 months. The overall incidence 46/1000 child weeks. Diarrhea more common than RH (relative (RR), 1.75; 95% confidence interval (CI), 1.38 2.22; P < 0.001). Poor hygienic...
Abstract The Roman Empire expanded through the Mediterranean shores and brought human mobility cosmopolitanism across this inland sea to an unprecedented scale. However, if was also common at frontiers remains undetermined. Balkans Danube River were of strategic importance for Romans acting as East-West connection a defense line against “barbarian” tribes. We generated genome-wide data from 70 ancient individuals present-day Serbia dated first millennium CE; including Viminacium, capital...
Ancient pathogen genomics is an emerging field allowing reconstruction of past epidemics. The demise post-contact American populations may, at least in part, have been caused by paratyphoid fever brought Europeans. We retrieved genome-wide data from two Spanish soldiers who were besieging the city Barcelona 1652, during Reapers' War. Their ancestry derived Basque region and Sardinia, respectively, (at that time, this island belonged to kingdom). Despite proposed plague epidemic, we could not...
The Asian Central Steppe, consisting of current-day Kazakhstan and Russia, has acted as a highway for major migrations throughout history. Therefore, describing the genetic composition past populations in Asia holds value to understanding human mobility this pivotal region. In study, we analyse paleogenomic data generated from five humans Kuygenzhar, Kazakhstan. These individuals date early mid-18th century, shortly after Kazakh Khanate was founded, union nomadic tribes Mongol Golden Horde...
We provide a functional characterization of transcription factor NF-κB in protists and information about the evolution diversification this biologically important protein. characterized two using phylogenetic, cellular, biochemical techniques. holozoan Capsaspora owczarzaki (Co) has an N-terminal DNA-binding domain C-terminal Ankyrin repeat (ANK) domain, its specificity is more similar to metazoan proteins than Rel proteins. Removal ANK allows Co-NF-κB enter nucleus, bind DNA, activate...
Abstract Disclosure: J.A. Pérez: None. A. Tapia-Castillo: Martinez: P. Carrion: M. Hernandez: R. Pinilla: C.E. Fardella: C.A. Carvajal: Primary aldosteronism (PA) is caused by aldosterone producing adenoma, bilateral adrenal hyperplasia and genetic forms, including familial hyperaldosteronism type I (FH-I). Patients with FH-I exhibit high levels of leading to several arterial hypertension (AHT), left ventricular hypertrophy (LVH) other cardiovascular manifestations such as endothelial...
Abstract Lack of proper nutrition (malnutrition) or the complete absence all food (starvation) have important consequences on physiology organisms. In many cases, nutritional status affects immunity, but, for most part, relationship between and immunity has been limited to studies in vertebrates terrestrial invertebrates. Herein, we describe a positive correlation sea anemone Nematostella vectensis . Gene expression profiling adult fed starved anemones showed downregulation genes involved...
Abstract Disclosure: C.A. Carvajal: None. M.P. Hernandez: P. Carrion: A. Tapia: J.A. Lopez: Vecchiola: C.E. Fardella: Sandoval-Borquez: During obesity, white adipose tissue (WAT), undergoes hypertrophic and hyperplastic changes by differentiation of preadipocytes into adipocytes, which increase the expression PPARγ, FASN, FABP4, adiponectin genes. These adipokines play a key role in obesity progression cell communication. WAT also causes chronic inflammatory state that modifies gene...
Ancient pathogen genomics is an emerging field allowing reconstruction of the origins and spread past epidemics. Recent studies have provided evidence that demise local American populations during post-contact period may, at least in part, been caused by paratyphoid fever brought to New World European colonizers. In this study, we retrieved genome-wide data from two Spanish soldiers who were thought died Plague while besieging city Barcelona 1652, Reapers' War. We found one soldier's...
Abstract In this report, we investigate the evolution of transcription factor NF-κB by examining its structure, activity, and regulation in two protists using phylogenetic, cellular, biochemical techniques. Capsaspora owczarzaki ( Co ), find that full-length has an N-terminal DNA-binding domain a C-terminal Ankyrin (ANK) repeat inhibitory domain, activity is more similar to metazoan rather than Rel proteins. As with mammalian proteins, removal ANK repeats required for -NF-κB enter nucleus,...