Patrice Muret
A5017826678- HIV/AIDS drug development and treatment
- HIV Research and Treatment
- Skin Protection and Aging
- Advancements in Transdermal Drug Delivery
- HIV/AIDS Research and Interventions
- Dermatology and Skin Diseases
- Contact Dermatitis and Allergies
- Hepatitis C virus research
- Wound Healing and Treatments
- HIV-related health complications and treatments
- Pharmacological Effects and Toxicity Studies
- Essential Oils and Antimicrobial Activity
- Analytical Methods in Pharmaceuticals
- Cancer Treatment and Pharmacology
- Hepatitis B Virus Studies
- Analytical Chemistry and Chromatography
- Cardiac Ischemia and Reperfusion
- Multiple Myeloma Research and Treatments
- Pneumocystis jirovecii pneumonia detection and treatment
- Antibiotics Pharmacokinetics and Efficacy
- Pesticide Exposure and Toxicity
- Autoimmune Bullous Skin Diseases
- Pharmaceutical studies and practices
- Reconstructive Surgery and Microvascular Techniques
- Textile materials and evaluations
Université de franche-comté
2007-2023
Centre Hospitalier Universitaire de Besançon
2010-2023
Université Bourgogne Franche-Comté
2018-2023
Institut Pasteur
2021
Université de Montpellier
2020
Centre Hospitalier Universitaire de Montpellier
2020
Inserm
2010-2019
Hospices Civils de Lyon
2019
Hôpital Privé Jean Mermo
2004-2019
Société Française de Rhumatologie
2014
Abstract: Concern is continuously raised about the safety of parabens which are present in most cosmetic preparations. In this investigation, methyl‐, ethyl‐, propyl‐ and butyl paraben (MP, EP, PP, BP), a commercial lotion, were deposited on human skin fragments, collected after surgical operations. Permeated determined their passage through epidermis–dermis layers, fixed Franz diffusion cells. Bovine serum albumin (3%) was employed as receptor fluid. Then, assessed by liquid chromatography....
ABSTRACT Daptomycin exhibits clinical activity in the treatment of infections with Gram-positive organisms, including due to methicillin-resistant Staphylococcus aureus . However, little is known about its penetration into bone and synovial fluid. The aim our study was assess daptomycin fluid after a single intravenous administration. This conducted 16 patients who underwent knee or hip replacement received dose 8 mg per kg body weight prior surgery. Plasma concentrations were measured 1 h...
It is a general rule that percutaneous absorption increased when the site of application occluded. In this study we compared in vitro permeation profiles two molecules with different physicochemical properties under occluded versus unoccluded conditions. Human abdominal skin samples were mounted on Dianorm® Teflon® macro 1 cells and Franz diffusion which represented or conditions, respectively. Our data show occlusion citropten (lipophilic compound) 1.6 times whereas caffeine (amphiphilic...
To analyse the frequency and causes of treatment discontinuation in patients who were treated with an integrase strand transfer inhibitor (INSTI), a focus on neuropsychiatric adverse events (NPAEs). Patients 18 HIV reference centres France prospectively included Dat'AIDS cohort. Data collected from all starting INSTI-containing regimen between 1 January 2006 31 December 2016. All discontinuations analysed, patients' characteristics related to due NPAEs sought. INSTIs prescribed 21315...
Abstract Background Integrase strand transfer inhibitors (INSTIs) are increasingly used in patients living with HIV due to their safety, effectiveness and high genetic barrier. However, an association weight gain has recently been suggested several cases of diabetes mellitus have reported raltegravir dolutegravir. The long-time metabolic impact these recent molecules remains unclear. Objectives To assess if INSTI as a third agent is statistically associated new-onset compared NNRTI or PI....
Summary As time passes, wrinkles typically appear. These skin depressions that become deeper and draw more coarser lines on almost all the visible parts of aging individual’s skin. They are indeed most obvious maybe disliked signs aging, thus, preventing treating them a major topic for dermo‐cosmetic laboratories. However, cause occurrence mechanism these simplistic looking not yet fully understood. Wrinkling is thought to be complex biophysical process resulting from repeated strains...
The anticancer drug capecitabine and its metabolites [including the active metabolite 5-fluorouracil (5-FU)] display high pharmacokinetic inter-patient variability. Such variability, which may lead to treatment failure or toxicity, could need concentration measurement individualize dosing regimen. However, usual assay methods are often long fastidious. A simultaneous cost-effective method was thus developed for determination of concentrations these compounds in human plasma. Compounds were...
Topical ceramide application is an effective therapeutic approach in skin disorders with disturbed barrier function, including atopic dermatitis and psoriasis.To evaluate analogue N-tetracosanoyl-(l)-serine tetradecyl ester (14S24) using a novel ex vivo model.Freshly excised human was disrupted by lipid extraction, tape stripping sodium lauryl sulphate (SLS) treatment. Barrier perturbation evaluated the measurement of transepidermal water loss (TEWL), hydration penetration model compound,...
Background Nucleoside reverse transcriptase inhibitor (NRTI) and protease (PI)/ritonavir sparing regimens may be useful to some HIV-infected patients. Nevirapine (NVP) raltegravir (RAL) are both potent antiretrovirals with good long-term safety profiles. Methods We retrospectively identified from our electronic database all patients HIV RNA<50 copies/ml for >6 months on an NVP-containing regimen no prior exposure integrase strand transfer inhibitors who were switched RAL plus NVP. Data...
Background. Prevention of mother-to-child transmission (PMTCT) human immunodeficiency virus (HIV) is usually based on zidovudine-containing regimens, despite potential toxicities. This multicenter trial evaluated whether lopinavir/ritonavir (LPV/r) monotherapy in HIV type 1–infected women not requiring antiretrovirals for themselves could control maternal viral load (VL).
Abstract Objectives To analyse the occurrence of virological failure (VF) in patients starting ART with an integrase strand transfer inhibitor (INSTI)-based regimen recent years, relation previous episodes low-level viral load (LLVL). Patients and methods a first between 1 January 2015 31 December 2020 based on two NRTIs one INSTI were included if after control (two measures VL &lt; 50 copies/mL) they had minimum additional measurements. Cox models adjusted for sex, age, acquisition...
Cutaneous warts are caused by infection of the epidermis with human papillomavirus (HPV). Cryotherapy using liquid nitrogen is one most common local treatments. In this study, we used a novel ex vivo approach to compare efficacy new product conventional liquid‐nitrogen cryotherapy studying epidermal histology and assessing presence HPV types 1 2 DNA in plantar warts. The studied formulation, which acts tissues mummification, combination nitric acid, organic acids metallic salts. We found...
Emtricitabine/tenofovir/rilpivirine as a single-tablet regimen (STR) is widely used without licence in treatment-experienced patients. The purpose of this retrospective observational study was to assess viral suppression ART-experienced patients switching STR.We assessed 131 pretreated STR with HIV RNA <400 HIV-1 copies/mL. primary outcome measure the proportion at week 24 <40 copies/mL.By 24, eight had stopped STR: four because adverse events and for other reasons. Three virological...
Atopic dermatitis (AD) is a chronic inflammatory skin disease in which reactive oxygen species (ROS) may be involved. Iron catalyses ROS formation and ascorbic acid (AA) scavenges these species.The aim of this work was to determine iron AA levels AD patients' dermis compare their concentrations with those healthy volunteers' dermis.Five patients 5 subjects (controls) were enrolled study. collected from human by microdialysis assessed atomic absorption spectrometry gas chromatography-mass...
Background/purpose: The aim of this study was to validate an optic device used measure the quantity light reflected by skin, which depends on brightness skin. Methods: This apparatus gives three parameters, called Complexion/diffusion (Cd), Cr (Complexion/reflection) and Complexion/specular position (Csp). Measurements were carried out forehead (slightly rounded surface) cheekbone (angular surface). To estimate repeatability reproducibility each parameter, two female subjects (one with a...
Maintenance ART with dolutegravir-based dual regimens have proved their efficacy among HIV-1-infected subjects in randomized trials. However, real-life data are scarce, limited populations and follow-up.We assessed virological failure (VF) resistance-associated mutations (RAMs) on dolutegravir maintenance combination rilpivirine or lamivudine emtricitabine (xTC) analysed the factors associated VF.Between 2014 2018, all adults included Dat'AIDS cohort starting dolutegravir/rilpivirine...
<i>Background:</i> Reactive oxygen species (ROS) contribute to processes relating cutaneous aging. Iron catalyses ROS formation whereas ascorbic acid (AA) plays a fundamental role in defending the organism against undesirable action. <i>Objective:</i> The aim of this work was determine ex vivo iron and AA concentrations human dermis from different age groups better understand their role. <i>Methods:</i> Skin fragments were collected 66 female patients...
Reactive oxygen species play an important role in inflammatory skin diseases such as psoriasis. synthesis is catalysed by iron and some are scavenged ascorbic acid. The aim of this work was to assess acid uninvolved involved psoriatic dermis compare the corresponding concentrations healthy subjects. Microdialysis associated with atomic absorption spectrometry gas chromatography-mass used acid, respectively. Seven patients five volunteers were studied. Iron (57.1 +/- 19.3 microg/l) (49.7 27.1...
Background: The intra‐dermal capillary network can be easily assessed by a computerized videomicroscope system. Nevertheless, finding loops automatically in an image is difficult yet important first step order to achieve microcirculation analysis. Methods: A detection system was tested combining videocapillaroscopy and principal component analysis (PCA). Our goal build generic detector of associated with retinally connected neural filter. filter examines small windows image, decides this...
Abstract Background We assessed prevalence of multimorbidity (MM) according to year human immunodeficiency virus (HIV) diagnosis in elderly people living with HIV (PLWH). Methods This was a cross-sectional study MM PLWH aged ≥70 years from the Dat’AIDS French multicenter cohort. defined as at least 3 coexistent morbidities high blood pressure, diabetes mellitus, osteoporosis, non-AIDS cancer, chronic renal failure, cardiovascular and cerebrovascular disease, obesity, undernutrition, or...