Anne Conrad
A5005016980- Orthopedic Infections and Treatments
- Antimicrobial Resistance in Staphylococcus
- Hematopoietic Stem Cell Transplantation
- SARS-CoV-2 and COVID-19 Research
- Reformation and Early Modern Christianity
- Infectious Diseases and Tuberculosis
- Antibiotics Pharmacokinetics and Efficacy
- HIV Research and Treatment
- Pneumonia and Respiratory Infections
- Hepatitis B Virus Studies
- Historical Gender and Feminism Studies
- COVID-19 Clinical Research Studies
- Surgical site infection prevention
- Long-Term Effects of COVID-19
- Orthopaedic implants and arthroplasty
- Streptococcal Infections and Treatments
- HIV/AIDS Research and Interventions
- Immunotherapy and Immune Responses
- HIV/AIDS drug development and treatment
- Blood disorders and treatments
- Infective Endocarditis Diagnosis and Management
- Sociology and Education Studies
- Immune Response and Inflammation
- COVID-19 and healthcare impacts
- Legionella and Acanthamoeba research
Hospices Civils de Lyon
2013-2025
Centre International de Recherche en Infectiologie
2018-2025
Université Claude Bernard Lyon 1
2018-2025
Centre National de la Recherche Scientifique
2018-2025
Inserm
2018-2025
École Normale Supérieure de Lyon
2018-2025
Hôpital de la Croix-Rousse
2018-2025
Prothena (United States)
2023
Hôpital Edouard Herriot
2013-2022
University of Arizona
2019
Abstract Background On 7 February 2020, French Health authorities were informed of a confirmed case severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in an Englishman infected Singapore who had recently stayed chalet the Alps. We conducted investigation to identify secondary cases and interrupt transmission. Methods defined as person linked with positive reverse-transcription polymerase chain reaction sample for SARS-CoV-2. Results The index 4 days 10 English tourists family 5...
Importance There is still considerable controversy in the literature regarding capacity of intramuscular messenger RNA (mRNA) vaccination to induce a mucosal immune response. Objective To compare serum and salivary IgG IgA levels among mRNA-vaccinated individuals with or without previous SARS-CoV-2 infection. Design, Setting, Participants In this cohort study, SARS-CoV-2–naive participants those infection were consecutively included CoviCompare P M mRNA trials followed up day 180 after...
Local injection of a bacteriophages mix during debridement, antibiotics and implant retention ("DAIR") was performed to treat relapsing Staphylococcus aureus chronic prosthetic joint infection (PJI). This salvage treatment safe associated with clinical success. Scientific evaluation the potential benefit as antibiofilm in PJI is now feasible required.
In a parallel-group, international, phase 3 study (ClinicalTrials.govNCT04762680), we evaluated prototype (D614) and Beta (B.1.351) variant recombinant spike protein booster vaccines with AS03-adjuvant (CoV2 preS dTM-AS03).Adults, previously primed mRNA (BNT162b2, mRNA-1273), adenovirus-vectored (Ad26.CoV2.S, ChAdOx1nCoV-19) or dTM-AS03 [monovalent D614; MV(D614)]) were enrolled between 29 July 2021 22 February 2022. Participants stratified by age (18-55 ≥ 56 years) received one of the...
Background:P. aeruginosa implant-associated bone and joint infections (BJI) is considered to be one of the most difficult treat BJI. The data focusing specifically on this pathogen are sparse, it seems extrapolate results obtained with Enterobacteriaceae. Methods: We performed a retrospective observation study all P. BJI diagnosed at our institution from 2011 2018. defined failure as any type relapse, including persistence same aeruginosa, superinfection by another organism(s) or other cause...
Modified vaccinia virus Ankara vaccine (MVA-BN; Bavarian Nordic) is recommended to contacts of mpox cases up 14 days post-exposure but the effectiveness this strategy unknown. Among 108 adults (≥ 18 years old) who received one dose MVA-BN after exposure mpox, 11 (10%) breakthrough were observed. Sexual was associated with risk (p = 0.0179). Samples taken from vaccinated had similar rates infectious isolation than unvaccinated cases.
Abstract Purpose Abdominal wall reconstruction is a common surgical procedure, with post-operative risk of mesh-associated infection which management poorly known. This study aims to comprehensively analyze clinical and microbiological aspects mesh infection, treatment modalities, associated outcomes. Methods Patients abdominal were included in retrospective observational cohort (2010-2023). characteristics described, determinants for failure assessed by logistic regression failure-free...
Torque teno virus (TTV) has been proposed as a surrogate biomarker of T-cell function in allogeneic-haematopoietic-stem-cell transplantation (allo-HSCT). Conflicting data exists regarding the value TTV to assess degree immunosuppression. The aim present study was investigate correlation between viral load and immune function. Using samples from prospective cohort composed healthy-volunteers (HV) allo-HSCT recipients at 6 months post-transplantation, we assessed viraemia cell counts or...
Introduction: Corynebacteria represent often-neglected etiological agents of post-traumatic and/or post-operative bone and joint infection (BJI). We describe here clinical characteristics bacteriological determinants this condition. Methods: A retrospective cohort study described characteristics, outcome treatment failure all patients with proven Corynebacterium spp. BJI (i.e., ≥2 culture-positive gold-standard samples). Available strains were further characterized regarding their antibiotic...
In the search for control of human immunodeficiency virus type 1 (HIV-1) infection without antiretroviral therapy, posttreatment controllers (PTCs) are models HIV remission. To better understand their mechanisms control, we characterized blood reservoirs 8 PTCs (median 9.4 years after treatment interruption) in comparison with those 13 natural (HICs) 18 infection) and individuals receiving efficient therapy initiated during either primary (PHIs; n = 8) or chronic (CHIs; 6). This...
Data on immunogenicity and safety of the recommended revaccination schedule against diphtheria, tetanus, poliomyelitis, pertussis, Haemophilus influenzae type b (Hib), hepatitis B in adult allogeneic hematopoietic stem cell transplantation (allo-HSCT) recipients are limited. This prospective single-center cohort study (April 2014 to March 2018) included allo-HSCT referred a dedicated vaccinology consultation vaccinated with pediatric combined acellular virus, inactivated poliovirus,...
Abstract Objectives To analyse the occurrence of virological failure (VF) in patients starting ART with an integrase strand transfer inhibitor (INSTI)-based regimen recent years, relation previous episodes low-level viral load (LLVL). Patients and methods a first between 1 January 2015 31 December 2020 based on two NRTIs one INSTI were included if after control (two measures VL < 50 copies/mL) they had minimum additional measurements. Cox models adjusted for sex, age, acquisition...
A 71-year-old man (85 kg) has a past history of vitiligo, ischemic myocardiopathy, and bilateral knee arthroplasties. 1-stage exchange the right prosthetic-joint infection (PJI) was done in 2016 for mechanical prosthetic loosening. massive constrained joint used to compensate bone loss (Supplementary Figure S1A). Iterative postoperative dislocations were followed by occurrence fistula January 2017 loosening S1B) without any pain. Because it impossible imagine 2-stage exchange, debridement...
Optimal treatment of prosthetic joint infection and chronic osteomyelitis consists surgical removal biofilm-embedded bacteria, followed by a 6-12 week course antimicrobial therapy. However, when optimal surgery is not feasible, oral prolonged suppressive antibiotic therapy (PSAT) recommended to prevent prosthesis loosening and/or relapse infection. Since 2010, we have used salvage using off-label subcutaneous (sc) injection β-lactam as PSAT for patients in whom possible.A single-centre...
Abstract Background BK polyomavirus associated nephropathy (BKPyVAN) is a significant clinical issue in kidney transplant (KT) recipients. No specific therapy currently available, although treatment with leflunomide may be part of the therapeutic strategy. Here, we sought to examine impact on evolution BKPyVAN. Methods This was an observational retrospective study conducted 3 French centers. KT recipients who developed BKPyVAN and received after failure other approaches were deemed eligible....
Daptomycin is a candidate for therapeutic drug monitoring (TDM). The objectives of this work were to implement and compare two pharmacometric tools daptomycin TDM precision dosing. A nonparametric population PK model developed from patients with bone joint infection was implemented into the BestDose software. published parametric imported Tucuxi. We compared performance models in validation dataset based on mean error (ME) absolute percent (MAPE) individual predictions, estimated exposure...