Pierre Chauvelot
A5087054807- Orthopedic Infections and Treatments
- Streptococcal Infections and Treatments
- Diphtheria, Corynebacterium, and Tetanus
- Antimicrobial Resistance in Staphylococcus
- SARS-CoV-2 and COVID-19 Research
- Wound Healing and Treatments
- Sinusitis and nasal conditions
- Pressure Ulcer Prevention and Management
- Surgical Sutures and Adhesives
- Ocular Diseases and Behçet’s Syndrome
- Sarcoidosis and Beryllium Toxicity Research
- Respiratory viral infections research
- Antibiotics Pharmacokinetics and Efficacy
- Neutropenia and Cancer Infections
- Ear Surgery and Otitis Media
- Biosimilars and Bioanalytical Methods
- Infective Endocarditis Diagnosis and Management
- Long-Term Effects of COVID-19
- Infectious Diseases and Tuberculosis
- Antimicrobial agents and applications
- Total Knee Arthroplasty Outcomes
- Fungal Infections and Studies
- Microbial infections and disease research
- Vector-borne infectious diseases
- SARS-CoV-2 detection and testing
Hospices Civils de Lyon
2017-2025
Pathophysiology, Diagnosis and Treatment of Bone Diseases
2024
Hôpital de la Croix-Rousse
2017-2021
Centre National de la Recherche Scientifique
2020-2021
Centre International de Recherche en Infectiologie
2020-2021
Inserm
2020-2021
École Normale Supérieure de Lyon
2021
Université Claude Bernard Lyon 1
2019-2021
bioMérieux (France)
2020
Institut National des Sciences Appliquées de Lyon
2020
Abstract Background On 7 February 2020, French Health authorities were informed of a confirmed case severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in an Englishman infected Singapore who had recently stayed chalet the Alps. We conducted investigation to identify secondary cases and interrupt transmission. Methods defined as person linked with positive reverse-transcription polymerase chain reaction sample for SARS-CoV-2. Results The index 4 days 10 English tourists family 5...
Introduction: Corynebacteria represent often-neglected etiological agents of post-traumatic and/or post-operative bone and joint infection (BJI). We describe here clinical characteristics bacteriological determinants this condition. Methods: A retrospective cohort study described characteristics, outcome treatment failure all patients with proven Corynebacterium spp. BJI (i.e., ≥2 culture-positive gold-standard samples). Available strains were further characterized regarding their antibiotic...
Abstract Background Early inhibition of entry and replication the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a very promising therapeutic approach. Polyclonal neutralizing antibodies offers many advantages such as providing immediate immunity, consequently blunting an early pro-inflammatory pathogenic endogenous antibody response lack drug-drug interactions. By immunity inhibiting into cells, treatment interest for patient with COVID-19-induced moderate pneumonia....
To assess the usefulness of 18F-fluorodeoxyglucose positron emission tomography (18F-FDG PET/CT) and predictive factors for diagnosis sarcoidosis in patients with uveitis who have normal thoracic tomography.We retrospectively reviewed 67 consecutive unknown aetiology or a suspected sarcoidosis. All underwent an 18F-FDG PET/CT, which was blindly reinterpreted. We then assessed proportion positive PET/CT impact on final aetiology, using Abad's criteria intraocular sarcoidosis.19 (28.4%) had...
Daptomycin is increasingly used in the treatment of bone and joint infection (BJI), but its pharmacokinetics (PK) dosage requirements have not been thoroughly investigated this indication. may be co-administered with rifampicin, which raises questions about a potential drug interaction. To investigate population PK daptomycin patients BJI, examine influence rifampicin co-administration. A approach was to analyse data from who received our regional reference for BJI. We examined available...
The use of piperacillin/tazobactam with vancomycin as empirical antimicrobial therapy (EAT) for prosthetic joint infection (PJI) has been associated an increased risk acute kidney injury (AKI), leading us to propose cefepime alternative since 2017 in our reference centre.To compare microbiological efficacy and tolerance these two EAT strategies.All adult patients PJI empirically treated vancomycin+cefepime (n = 89) were enrolled a prospective observational study matched...
Abstract Background Necrotizing external otitis (NEO) is a severe infection of the skull base that occurs generally in elderly and/or diabetic recipients. There are few data literature about therapeutic management this complex bone infection. Objectives To analyse relapses after NEO treatment completion, and to describe clinical features NEO. Methods We performed retrospective cohort study Lyon regional reference centre for joint infections. Consecutive cases from 1 January 2006 31 December...
Q fever is a zoonotic disease caused by the bacterium Coxiella burnetii, strictly intracellular pathogen that can cause acute and chronic infection. Chronic occur in immunocompetent as well immuno-compromised hosts, persistent localized The main localizations are endocardial, vascular and, less frequently, osteoarticular. most frequent osteoarticular form spondyliscitis. Recommended treatment combined doxycycline hydroxychloroquine for 18 months, with cotrimoxazole another option. burnetti...
Management of any wound, either acute or hard-to-heal, might involve the use multiple and different wound dressings in its treatment. This approach is necessary to overcome myriad clinical challenges presents, as well underlying comorbidities that affect outcomes. article describes effectiveness a coordinated dressing treatment regimen.This was an open-labelled non-comparative study involving patients with variety hard-to-heal wounds differing levels severity, but all which required removal...
Long-acting lipoglycopeptides are promising therapeutic options in Staphylococcus aureus bone and joint infections (BJIs). This study evaluated the ability of dalbavancin to eradicate intraosteoblastic reservoir S. aureus, associated with BJI chronicity.Osteoblastic cells were infected a standardized inoculum reference strain HG001 incubated for 24 h dalbavancin, vancomycin or rifampicin using MIC, 10×MIC, 100×MIC and/or intraosseous concentrations reached standard doses (i.e. vancomycin, 10...
Over the course of a wound's healing trajectory, whether wound is acute or hard-to-heal, management likely to involve use several different dressing types. Minimising complexity treatment (in terms usage) would aid clinicians in providing effective care but excellent clinical outcomes must remain primary goal.This study was an open-labelled, non-comparative assessing effectiveness coordinated regimen. After initial phase using hydro-responsive (HydroClean, HRWD-1, PAUL HARTMANN AG, Germany)...
Abstract Background Corynebacterium is a rare etiologic agent of BJI. We aimed to describe this clinical condition and assess treatment failure determinants. Methods All adult patients with proven BJI (i.e., consistent clinical/radiological signs, AND ≥2 reliable positive bacteriological samples, treated as such) were included in retrospective cohort study. After description, determinants infection persistence, relapse, requirement additional surgical procedure, BJI-related death) determined...