A5046443353- Mechanical Circulatory Support Devices
- Cardiac Valve Diseases and Treatments
- Anatomy and Medical Technology
- Cardiac Structural Anomalies and Repair
- Infective Endocarditis Diagnosis and Management
- Cardiac pacing and defibrillation studies
- Medical Imaging Techniques and Applications
- Congenital Heart Disease Studies
- Aortic Disease and Treatment Approaches
- Cardiac Arrhythmias and Treatments
- Advanced Battery Technologies Research
- Surgical Simulation and Training
- Advanced X-ray and CT Imaging
- Fuel Cells and Related Materials
- Cardiac and Coronary Surgery Techniques
- Cardiac Arrest and Resuscitation
- Organ Transplantation Techniques and Outcomes
- Advanced Radiotherapy Techniques
- Organ Donation and Transplantation
- Cervical and Thoracic Myelopathy
- Radiation Therapy and Dosimetry
- Central Venous Catheters and Hemodialysis
- Tracheal and airway disorders
- Hip disorders and treatments
- Facial Rejuvenation and Surgery Techniques
Cleveland Clinic
2006-2024
Cleveland Clinic Lerner College of Medicine
2008-2020
Bayer (Mexico)
2015
Merck Serono (Switzerland)
2015
Five Prime Therapeutics (United States)
2015
Gilead Sciences (Australia)
2015
Quest Diagnostics (United States)
2015
Janssen (Switzerland)
2015
Sir Charles Gairdner Hospital
2015
Sanofi (Mexico)
2015
The growing demand for liver transplantation and the concomitant scarcity of cadaveric livers have increased need living donor (LDLT). Ensuring safety donors recipients is critical. preoperative identification vascular biliary tract anatomy with 3-dimensional (3D) printing may allow better surgical planning, avert unnecessary surgery in patients potentially unsuitable anatomy, thereby decrease complications transplant surgery. We developed a protocol successfully 3D-printed synthetic (along...
The use of three-dimensional (3D) anatomical models is ubiquitous in medical education. Medical educators rely on to depict structures a more efficient format than the cadaver; move away from clutter, discomfort, and complexity cadaveric dissection; clarify characteristics or functions an structure that are not readily apparent situ. Here, we review physical teaching sciences In addition, examine production digital 3D for interactive media using additive manufacturing (3D printing) methods....
Air–liquid interface cell culture is an organotypic model for study of differentiated functional airway epithelium in vitro. Dysregulation cellular energy metabolism and mitochondrial function have been suggested to contribute diseases. However, there currently no established method determine oxygen consumption glycolysis air–liquid interface. In order epithelial cells, we engineered insert the Seahorse XF24 Analyzer that enabled measure respiration by rate (OCR) extracellular acidification...
The lesion detection performance of SPECT and PET scanners is most commonly evaluated with a phantom containing hollow spheres in background chamber at specified radionuclide contrast ratio. However, there are limitations associated miniature version sphere for small-animal scanners. One issue that the 'wall effect' zero activity wall fill port causes significant errors small diameter spheres. Another practical difficulties fabricating filling very (<3 mm diameter). need assessment has...
OBJECTIVESWe designed a device that applies motion-activated energy (vibration) to prevent chest-tube clogging and maintain tube patency. We evaluated the efficacy of this in vitro vivo.
The MagScrew Total Artificial Heart (TAH) system is the result of a close collaboration among Cleveland Clinic Foundation, Foster Miller Technologies, Wilson Greatbatch Ltd, and Whalen Biomedical Inc. components are thoracic blood pumping unit with attached compliance chamber refill port, implantable electronic control unit, battery pack, transcutaneous energy transmission system, external telemetry for communication unit. System in vitro tests underway characterization durability...
In certain populations, open heart surgery to replace a diseased mitral valve is not an option, leaving percutaneous delivery viable alternative. However, surgical transcatheter based of metallic support frame incorporating tissue derived puts considerable constraints on device specifications. Expansion large diameter from the catheter without mechanical fracture involves advanced design and appropriate material processing selection. this study, new concept presented with desirable feature...
Abstract: To evaluate the effects of downsizing total artificial heart (TAH), we compared anaerobic threshold (AT) values in calves with two different types TAH (Cleveland Clinic–Nimbus and downsized MagScrew TAH). Exercise studies were performed using a treadmill 12 calves. During exercise, parameters to obtain AT measured. determinants AT, linear regression analysis was between potential variables. from 29 revealed no significant differences TAHs, hemodynamic or oxygen metabolic...
Primary tricuspid valve (TV) disease is rare and associated with high operative mortality. Optimal surgical planning requires a precise understanding of the pathological features; however, detailed imaging TV can be challenging. We present 4 cases primary where 3-dimensional printing was pivotal to success. (Level Difficulty: Advanced.)
Abstract: MagScrew total artificial heart (TAH) external battery pack (EBP) cycle bench testing was conducted on two Wilson Greatbatch (Clarence, NY, USA) lithium ion EBPs over a period of 22 months during continuous charge and discharge cycles under simulated TAH system current requirement. A custom electronic load developed to simulate the waveforms typically observed nominal operation. These profiles were applied EBP test voltage‐defined cycle. endurance indicated 240‐min new diminishing...
Three-dimensional (3D) printing of anatomical structures has yielded valuable models for simulation, education, and surgical planning applications. Applications 3D have continued to expand include some ultrasound The goal this effort was evaluate if a printed model superficial femoral artery (SFA) would realistic characteristics. A computed tomography scan reconstructed segmented using TeraRecon Aquarius Intuition software (TeraRecon, Foster City, California) obtain an atherosclerotic SFA...
Cholestatic liver diseases are characterized by increased biliary proliferation and intrahepatic bile duct mass (IBDM), damage fibrosis.Melatonin, which is synthesized in the pineal gland as well cholangiocytes, exerts its effects interaction with MT1 MT2 receptors.Knockdown of increases fibrosis cholestatic mice.Also, melatonin inhibits hyperplasia interacting receptors.However, since these studies were performed only vitro, we evaluated role regulating vivo knockout (KO) mice, wild-type...
The MagScrew total artificial heart (TAH) is under development. Despite its anticipated durability and reliability, the possibility of a bioprosthetic valve malfunction exists. As result, potential for replacement surgery, instead device replacement, would be desirable after TAH implant. In two our 90-day animal experiments, we successfully replaced left-side valves through left thoracotomy opposite to right-sided incision site initial results these cases suggest that could also approach in...
Abstract MagScrew total artificial heart (TAH) external battery pack (EBP) cycle bench testing continued over a period of 18 months using two fresh Wilson Greatbatch lithium ion EBPs during continuous charge and discharge cycles under simulated TAH system current requirement. The same electronic load developed for our initial was used to simulate the waveforms typically observed nominal operation. profiles this test were modified from ones previously described applied EBP voltage‐defined...
A collimation device for 511 keV small animal SPECT/CT using clinical detectors was investigated as an alternative to dedicated PET/CT. The consists of a 45 mm thick collimator (lead cylinder with 30 tungsten pinhole inserts) and bed three-degrees-of-freedom. rests on the patient scanner, where gamma cameras rotate around collimator. inserts (1.5 diameter aperture 15° cone angle) were designed provide adequate line-of-sight shielding rays minimal penetration. Monte Carlo simulations...
Incompetent inflow valves have been reported with clinical pulsatile left ventricular assist devices that use bioprosthetic valves. Suspected as the cause of premature valve failure within these devices, absolute pressures and instantaneous pressure changes were evaluated in MagScrew total artificial heart (TAH). The TAH is a passively filling pump which uses reciprocating magnetic actuating mechanism under various control modes to propel blood into circulation. Both right ejection speeds...