A5010816717- Histiocytic Disorders and Treatments
- Parvovirus B19 Infection Studies
- Gastrointestinal disorders and treatments
- Immune Cell Function and Interaction
- Viral-associated cancers and disorders
- Acute Myeloid Leukemia Research
- Autoimmune and Inflammatory Disorders Research
- Acute Lymphoblastic Leukemia research
- Antibiotics Pharmacokinetics and Efficacy
- Vascular Malformations and Hemangiomas
- Immunodeficiency and Autoimmune Disorders
- Gastrointestinal Tumor Research and Treatment
- Genetic and rare skin diseases.
- Hematopoietic Stem Cell Transplantation
- Drug Transport and Resistance Mechanisms
- Pharmacogenetics and Drug Metabolism
- Pediatric Hepatobiliary Diseases and Treatments
- Gallbladder and Bile Duct Disorders
- Chronic Myeloid Leukemia Treatments
- Synthesis of Organic Compounds
- Soft tissue tumor case studies
- Clinical Nutrition and Gastroenterology
- Glioma Diagnosis and Treatment
- Retinoids in leukemia and cellular processes
- Appendicitis Diagnosis and Management
Shinshu University
2024-2025
Shiga University of Medical Science
2022-2024
National Center For Child Health and Development
2018-2024
Children's Cancer Center
2021-2024
Shiga University
2022
Kyoto Prefectural University of Medicine
2012-2019
Minoh City Hospital
2006-2019
National Hospital Organization
2014-2019
Nagoya Medical Center
2019
North Medical Center
2018
Abstract Surface phenotypic markers and the function of lymphocytes in patients affected with X-linked lymphoproliferative syndrome (XLP) were studied. This is characterized by a defective response to infection Epstein Barr virus (EBV). Normal numbers B T cells detected anti-Ig monoclonal OKT3 antisera, respectively. cell subset values, however, persistently altered: reacting OKT8 significantly elevated five nine patients, accompanied slight decrease percentage OKT4-positive cells, leading...
All-trans retinoic acid (ATRA) is well established as differentiation therapy for acute promyelocytic leukemia (APL) in which the PML–RARα (promyelocytic leukemia-retinoic receptor α) fusion protein causes blockade of (RA) pathway; however, types myeloid (AML) other than APL, mechanism RA pathway inactivation not fully understood. This study revealed potential high ATRA sensitivity mixed-lineage (MLL)-AF9-positive AML compared with MLL-AF4/5q31-positive AML. Treatment induced significant...
A comparative study was carried out on the effects of a soluble derivative baicalein, disodium baicalein 6-phosphate (BPS) and cromoglycate (DSCG) immediate type allergic reactions. BPS not only inhibited reaginic antibodymediated reactions including antigen-induced mediator release from monkey lung, homologous PCA in rats, antibody-mediated degranulation mast cell, but also non-reaginic such as guinea pig lung s ensitized with ovalbumin that human caused by antiIgE. The agent, however, did...
Abstract Recently, it has been reported that Crohn's‐like intractable colitis occurred in approximately 20% of the patients with XIAP deficiency, also known as X‐linked lymphoproliferative disease type 2. Because treatment used for Crohn's is not always effective related to more should be established. Although several studies allo‐ HSCT might promising even outcome using MAC deficiency extremely poor due frequent TRM. In addition, there little information about allo‐HSCT deficiency. Herein,...
Purpose Osteonecrosis (ON) is a serious complication of the treatment childhood acute lymphoblastic leukemia (ALL); however, data relating to ON in Asian pediatric patients with ALL are scarce. Therefore, we performed retrospective analysis cohorts Japanese clarify incidence, clinical characteristics, and risk factors ON. Patients Methods The incidence characteristics were determined (n = 1,662) enrolled two studies from Japan Association Childhood Leukemia Study (JACLS) group 635 n 1,027...
Allogeneic hematopoietic stem cell transplantation (HSCT) is performed as a curative treatment for children with nonmalignant diseases, such bone marrow failure syndromes and primary immunodeficiencies. Because graft-versus-host-disease (GVHD) major factor affecting survival probability quality of life after HSCT, the availability HLA-matched donors restricts application HSCT. Recently, HSCT post-transplantation cyclophosphamide (PTCy) has emerged potent method to prevent GVHD from...
Abstract Purpose We analyzed central diabetes insipidus (CDI) development in pediatric patients with Langerhans cell histiocytosis (LCH) treated according to the Japan LCH Study Group (JLSG) regimen, which is combination chemotherapy including cytarabine (Ara‐C). Methods Retrospective data from 317 (multisystem disease (MS), n = 206; multiple focal bone (MFB), 111) JLSG‐96/02 regimens were analyzed. Results The median follow‐up duration was 10.6 years (range, 0.1–21.1). A total of 50/317...
BRAF V600E-positive cells as molecular markers of bone marrow disease in pediatric Langerhans cell histiocytosis1][12][13][14][15] However, the mutation status and clinical impact BM (BMD) at level are not fully understood.In order to clarify measurable BMD LCH, we investigated somatic mutations paired tumor samples using a sensitive detection system.We retrospectively performed mutational analyses 59 LCH tumors by targeted amplicon sequencing custom-designed primers subsequently analyzed 41...
HSCT-associated thrombotic microangiopathy (TA-TMA) is a severe complication with poor prognosis. Recently, it has been reported that complement system dysregulation, such as CFH autoantibodies and deletions CFH-related genes 3 1, induced TA-TMA. In addition, C4d-positive renal arterioles are both good marker of activation useful diagnostic tool for Because dysregulation the associated TA-TMA, might be therapeutic target, eculizumab, terminal inhibitor. Herein, we describe an eight-yr-old...
Summary We performed a retrospective analysis of leukaemic surface antigen expression and genomic data from total 100 RUNX1‐RUNX1T1 –positive paediatric acute myeloid leukaemia (AML) patients enrolled in the Japanese Paediatric Leukaemia/Lymphoma Study Group (JPLSG) AML‐05 protocol to determine risk factors for relapse. In univariate analysis, KIT exon 17 mutation ( n = 21) CD19 negativity 59) were significant relapse P 0·01). multivariate was sole factor (hazard ratio, 3·09; 95% confidence...
Allogeneic hematopoietic stem cell transplantation (HSCT) is the treatment of choice for many high-risk pediatric hematological malignant diseases (MD) and several nonmalignant (NMD), including primary immune deficiencies. Infections must be managed to obtain better outcomes after HSCT. In this prospective observational study, viral monitoring was performed on 74 patients with MD NMD who underwent The incidence, risk factors, impact common opportunistic infections occurring within first 100...
<i>Background:</i> Imipenem is used to treat intra-abdominal infections, however, this treatment would benefit from a better understanding of imipenem penetration into the abdominal cavity. <i>Methods:</i> 500 mg was infused 10 laparotomy patients. The total drug concentrations in plasma and intraperitoneal fluid were analyzed noncompartmentally 3-compartmentally (population pharmacokinetic analysis), for Monte Carlo simulation with minimum inhibitory concentration...
Objectives To determine recent trends in mutation patterns the WRN gene, which cause Werner syndrome ( WS ), a rare, inheritable progeroid Japan. Design Retrospective cohort. Setting Longitudinal survey of and literature search for case reports. Participants Individuals whose genetic testing their facilities had requested between 2009 October 2016 (N = 67). Measurements A nationwide epidemiological study was conducted from to 2011 improve understanding pathology develop therapeutic...
Summary Langerhans cell histiocytosis (LCH) is a rare inflammatory myeloid neoplasia derived from immature dendritic cells with the mitogen‐activated protein kinase (MAPK) pathway gene mutation. LCH rarely fatal, but patients develop various permanent consequences (PCs). We report frequencies of LCH‐related PCs in paediatric ( n = 317) treated by JLSG‐96/02 AraC‐containing regimens. One‐third had at least one PC median follow‐up 12 years. Central nervous system (CNS)‐related (neurological...