A5100692860- Acute Lymphoblastic Leukemia research
- Mobile Health and mHealth Applications
- Childhood Cancer Survivors' Quality of Life
- Reproductive System and Pregnancy
- Retinoids in leukemia and cellular processes
- Endometriosis Research and Treatment
- Eicosanoids and Hypertension Pharmacology
- Chronic Lymphocytic Leukemia Research
- Uterine Myomas and Treatments
- Intensive Care Unit Cognitive Disorders
- Acute Myeloid Leukemia Research
- CAR-T cell therapy research
- Electronic Health Records Systems
- Mobile Learning in Education
- Calcium signaling and nucleotide metabolism
- Glutathione Transferases and Polymorphisms
- Chronic Disease Management Strategies
- Pregnancy and preeclampsia studies
- Anesthesia and Sedative Agents
- RNA modifications and cancer
- Atherosclerosis and Cardiovascular Diseases
- Ferroptosis and cancer prognosis
- Cardiac, Anesthesia and Surgical Outcomes
- Telemedicine and Telehealth Implementation
- Chronic Myeloid Leukemia Treatments
Capital Medical University
2015-2024
Beijing Children’s Hospital
2015-2024
Wuxi People's Hospital
2019-2024
Capital University
2022-2024
Academy of Medical Sciences
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2024
Peking University First Hospital
2024
Peking University
2024
Beijing Hospital
2024
Center for Children
2024
BACKGROUND The two-way, three-stage psychological intervention for patients with dental pulp disease offers a reference nursing interventions in such cases. AIM To examine the effects of on resilience and health behaviors. METHODS A total 114 treated between December 2022 2023 were allocated into two groups according to random lottery method, 57 each group. control group adopted teaching while observation used combined method. We compared resilience, coping strategies, fear, behavior habits,...
Abstract Aim The aim of the study was to explore impact nurse workloads on adherence hand hygiene. Background Adherence hygiene and nursing have been linked quality patient care. Therefore, it important understand relationship safe Design This cross‐sectional performed from January 2016 June 2016. Methods Workloads for nurses 3‐day shifts in a tertiary hospital were investigated Actual hours worked per shift timed using stopwatch assess workloads. Descriptive inferential statistics multiple...
Arsenic trioxide (ATO) has been found to be effective in acute promyelocytic leukemia. However, ATO-induced severe cardiotoxicity limits its clinical application. To date, the mechanisms of remain unclear. It is hypothesized that ferroptosis may trigger cardiotoxicity; however, this not yet investigated. clarify hypothesis, rat cardiomyocyte H9c2 cells were treated with ATO or without ferrostain-1 (Fer-1). The results indicated exposure induced cell death and apoptosis, inhibitor Fer-1,...
Aim: To evaluate the association between SLCO1B1 polymorphisms and elimination/toxicities of high-dose methotrexate (MTX). Methods: rs11045879 rs4149056 were retrospectively genotyped in 301 children with newly diagnosed acute lymphoblastic leukemia. MTX concentration, doses leucovorin rescue toxicities recorded. Results: rs11045879C carriers (CC + CT) had higher plasma levels at 96 hr, longer elimination time. The number rs4149056C was more than those TT ones. Moreover, associated HDMTX...
Recurrent spontaneous abortion (RSA) occurs in 1‑5% of parturients. The sustained therapy and research for RSA is expensive, which a serious issue faced by both patients doctors. aim the present study was to detect protein expression profiles serum healthy controls, identify potential biomarkers this disease. A 1,000‑protein microarray consisting combination Human L‑507 L‑493 used. data revealed that eight levels were significantly upregulated 143 proteins downregulated compared with...
The objective of this study was to examine the effects n-3 polyunsaturated fatty acids (n-3 PUFAs) on coronary arterial large conductance Ca2+-activated K+ (BK) channel function in smooth muscle cells (SMCs) streptozotocin-induced diabetic rats.The docosahexaenoic acid (DHA) and eicosapentaenoic (EPA) BK open probabilities were determined using patch clamp technique. mRNA protein expressions subunits measured qRT-PCR Western blots. artery tension SMC Ca2+ concentrations a myograph system...
This presentation will be in a workshop format with panel of presenters representing four countries. All speakers are authors and address various aspects from the content book published as result NI 2016 Post Conference Switzerland, Forecasting Informatics Competencies for Nurses Future Connected Health [1], before inviting audience to discuss share their views. The discussion focused on defining informatics competencies nurses practice requirements training nursing programs around world.
Although leukemic blast cells of Pro-B cell acute lymphoblastic leukemia (ALL) are arrested at the same stage B differentiation, immature subtype is still biologically heterogeneous and associated with diverse outcomes. This study aimed to explore clinical-biological characteristics pediatric pro-B ALL factors outcomes.This enrolled 121 patients aged 6 months 14 years newly diagnosed CD19+CD10- (pro-B ALL) treated Beijing Children's Hospital from March 2003 October 2018. Genetic...
Background: Infections remain a major cause of therapy-associated morbidity and mortality in children with acute lymphoblastic leukemia (ALL). Methods: We retrospectively analyzed the medical charts 256 treated for ALL under CCLG-2008 protocol Beijing Children's Hospital. Results: There were 65 infectious complications 50 patients during vincristine, daunorubicin, L-asparaginase dexamethasone induction therapy, including microbiologically documented infections (n = 12; 18.5%), clinically 23;...
Abstract The prethrombotic state (PTS) is a possible cause of recurrent spontaneous abortion (RSA). aim this study was to identify serum biomarkers for the detection RSA with PTS (PSRSA). A Quantibody array 440 used screen novel serum‐based PSRSA/NRSA (RSA without PTS). Proteins differentially expressed in PSRSA were analysed using bioinformatics methods and subjected customized enzyme‐linked immunosorbent assay (ELISA) validation. We receiver operating characteristic calculate diagnostic...
Introduction: In the past 30 years, prevalence of diabetes in China has increased from 0.67% to 11.6%. Self-management behaviors (SMBs) are significant improve health outcomes for diabetics. However, little is known about self-management experiences Chinese diabetic patients. The purpose this study was explore family factors affecting SMBs. Methodology: A qualitative descriptive used. Purposive samples were recruited communities. Semistructured interviews conducted, and audio-recordings...
To examine current status and quality of CVD related apps available for download in China, a total 151 from the top popular six app stores were analyzed. Data analysis uncovered range issues including missing key variables pre-formatted daily records, no platform interaction with relevant healthcare professionals undesirable user-interface design. More importantly, these had low levels adherence to internationally recognized guidelines management. Overall score was below average (8.08/20)....
<b><i>Aim:</i></b> Glucose fluctuations may be responsible for, or further the onset of arterial hypertension, but exact mechanisms remain unclear. The purpose this study was to investigate behind and related aortic fibrosis stiffening induced by glucose fluctuations. <b><i>Methods:</i></b> Sprague-Dawley rats were injected with streptozotocin (STZ) randomly divided into three treatment groups: controlled STZ-induced diabetes (C-STZ);...
Gastrodiae Rhizoma is a highly valuable traditional herbal medicine commonly used to treat neurological disorders. The present study designed determine the antidepressant-like effect of water extract (GRWE) on depression model and potential mechanisms. chronic unpredictable mild stress (CUMS) rat was induce depression. sucrose preference test, open field forced swimming tail suspension test were performed assess depressive-like behaviors, respectively. Hypothalamic–pituitary–adrenal (HPA)...
This article discusses the application effect of 'student-centered, teacher-led' practice mode. Using frame constructivist theoretical perspective and Lewin's action research, we selected mode, data sources included interviews, students' records questionnaires from students teachers. The results can be summarized in four aspects as follows: Self-regulated learning ability improved; clinical thinking advanced; profession further understood by students; a professional affection fostered. mode...
Aim: To evaluate the associations between human leukocyte antigen (HLA)-DRB1 variants and rs6021191 variant in nuclear factor of activated T cells 2 (NFATC2) with PEG-asparaginase hypersensitivity children acute lymphoblastic leukemia (ALL) treated according to Chinese Children Leukemia Group (CCLG) ALL 2018 protocol. Methods: HLA-DRB1 genotyping was performed using a PCR sequence-based typing (SBT) method. NFATC2 genotyped applying TaqMan Genotyping Assay. Results: T-ALL higher risk groups...
We studied the outcomes of children with APL treated by Beijing Children's Hospital's (BCH) acute promyelocytic leukemia (APL) 2005 protocol (BCH-APL2005). The clinical data 77 patients enrolled from January to June 2015 were analyzed retrospectively. hematologic complete remission (CR) rate and overall survival (OS) evaluated between standard-risk (SR) high-risk (HR) groups. Prognostic factors complications investigated in these two CR SR HR groups was 96.4% (54/56) 85.7% (18/21),...
Abstract Objective Traditional Chinese medicine (TCM) is an effective management to infertility. The association between TCM‐mediated fertility and inhibition of phosphatidylinositol‐3‐kinase (PI3K) would be investigated. Methods Institute Cancer Research mice were treated with three herbal decoctions, named Wenshen Yangxue formula, plus human gonadotropins. PI3K inhibitor wortmannin was administrated half mice. Some index such as body weight, ability expression P13K/Akt signaling detected...
We explored the desired features of medication applications for patients with chronic disease and their caregivers a questionnaire survey, 50 from caregivers. Although majority people (75%) are willing to use apps, actual usage rate is quite low (11%). Worrying about privacy personal information seems be main reason not using applications. The overall score was 3.29 &plusmn; 1.02 (out 5). Searching medications diseases assistance making doctors' appointments most wanted categories....