A5035366526- Mesenchymal stem cell research
- Tissue Engineering and Regenerative Medicine
- Electrospun Nanofibers in Biomedical Applications
- Magnetic properties of thin films
- 3D Printing in Biomedical Research
- Angiogenesis and VEGF in Cancer
- Pluripotent Stem Cells Research
- Bariatric Surgery and Outcomes
- Virus-based gene therapy research
- Advanced MRI Techniques and Applications
- Magnetic Properties and Applications
- Pancreatic function and diabetes
- Regulation of Appetite and Obesity
- Diabetes Treatment and Management
- MRI in cancer diagnosis
- Retinal Diseases and Treatments
- Peripheral Artery Disease Management
- Theoretical and Computational Physics
- Sarcoma Diagnosis and Treatment
- RNA Interference and Gene Delivery
- Physics of Superconductivity and Magnetism
- Microfluidic and Capillary Electrophoresis Applications
- Glaucoma and retinal disorders
- Anodic Oxide Films and Nanostructures
- Cancer Research and Treatments
Wenzhou Medical University
2025
First Affiliated Hospital of Wenzhou Medical University
2025
Johns Hopkins University
2012-2023
Johns Hopkins Medicine
2011-2023
Resonance Research (United States)
2022
University of Baltimore
2010-2021
Piedmont HealthCare
2018
Morgan State University
2016
Tianjin First Center Hospital
2014-2016
Tianjin Medical University
2014-2016
To evaluate the angiogenic inhibitory effects of an alpha(v)beta(3)/alpha(v)beta(5) integrin antagonist, EMD478761, released from a polymeric implant in chick chorioallantoic membrane (CAM) assay and laser-induced experimental choroidal neovascularization (CNV) rats.Polyvinyl alcohol-based reservoir implants releasing EMD478761 were designed for placement onto CAM or intravitreally rats. In vitro release rates measured using HPLC. Angiogenesis was induced on 10-day-old embryos by basic...
The therapeutic goal in peripheral arterial disease (PAD) patients is to restore blood flow ischemic tissue. Stem cell transplantation offers a new avenue enhance arteriogenesis and angiogenesis. Two major problems with therapies are poor survival the lack of visualization delivery distribution. To address these barriers, allogeneic bone marrow-derived mesenchymal stem cells (MSCs) were encapsulated alginate impregnated radiopaque contrast agent (MSC-Xcaps). In vitro MSC-Xcap viability by...
The magnetization reversal process of an ordered Co nanorod array is shown using the images obtained from successive in-field magnetic force microscope (MFM) measurements. model discussed according to local and whole properties measured by polar magneto-optical Kerr effect (PMOKE) alternating gradient magnetometer (AGM), respectively. Additionally, dipolar field was probed MFM By removing field, intrinsic switching distribution (SFD) in a map with hexagonal array. A detailed study arrays...
The magnetization reversal properties of a single 60 nm diameter Fe nanowire were investigated with an in-field magnetic force microscope (MFM). MFM images observed in successively decreasing applied field, at various angles between the field and axis. results show that undergoes sharp angles. When deviates from axis, before complete reversal, coherent rotation moments inside stable vortex state end are exhibited. angle dependence switching can be closely described by curling model, despite...
Despite rapid translation of stem cell therapy into clinical practice, the treatment cardiovascular disease using embryonic cells, adult and progenitor cells or induced pluripotent has not yielded satisfactory results to date. Noninvasive imaging techniques could provide greater insight only therapeutic benefit, but also fundamental mechanisms underlying fate, migration, survival engraftment in vivo. This information assist appropriate choice type(s), delivery routes dosing regimes trials....
Purpose To determine whether microsphere size effects ghrelin expression and weight gain after selective bariatric arterial embolization (BAE) in swine. Materials Methods BAE was performed 10 swine by using smaller (100–300 μm; n = 5) or larger (300–500 calibrated microspheres into gastric arteries. Nine control pigs underwent a sham procedure. Weight fasting plasma levels were measured at baseline weekly for 16 weeks. Ghrelin-expressing cells (GECs) the stomach assessed immunohistochemical...
To assess intrapericardial delivery of microencapsulated, xenogeneic human mesenchymal stem cells (hMSCs) by using x-ray fused with magnetic resonance (MR) imaging (x-ray/MR imaging) guidance as a potential treatment for ischemic cardiovascular disease in an immunocompetent swine model.All animal experiments were approved the institutional care and use committee. Stem cell microencapsulation was performed modified alginate-poly-l-lysine-alginate encapsulation method to include 10% (wt/vol)...
Transplantation is now lifesaving therapy for patients with end-stage organ failure but requires lifelong immunosuppression resultant morbidity. Current immunosuppressive strategies inhibit T cell activation and prevent donor-recipient engagement. Therefore, it not surprising that few host cells are demonstrated in donor grafts. However, our recent small animal studies found large numbers of recipient stem present after transplantation pharmacological mobilization, resulting a chimeric,...
A multi-nozzle device incorporating pseudo-check valves rapidly generates monodisperse, spherical microbeads, impregnated with X-ray contrast agents, suitable for targeted embolic therapy.
Magnetization reversal and magnetic domain structures controlled by the magnetostatically induced stray field in perpendicular antiferromagnetically coupled [Pd∕Co]7∕Ru∕Co∕[Pd∕Co]7 multilayer were investigated force microscopy. For sample demagnetized plane, field-induced ferromagnetic domains at boundary of antiferromagnetic provide nucleation channel. The channel are parallel aligned along applied out plane firstly, then magnetization is dominated propagation channels toward region...
Poor cell survival and difficulties with visualization of delivery are major problems current transplantation methods.To protect cells from early destruction, microencapsulation methods have been developed.The addition a contrast agent to the microcapsule also could enable tracking by MR, ultrasound, X-ray imaging.However, determining viability within still remains an issue.Reporter gene imaging provides way determine viability, but reporter probe systemic injection may be hindered in...
Kalanchoe blossfeldiana is an economically important potted flower in Taiwan. Necrotic spots affecting both leaves and stems of this plant were recently discovered different cultivated areas Taiwan including Nantou, Miaoli, Taoyuan Yilan Counties. The incidence the disease was usually more than 80% some severely diseased areas. Infected produced tan or brown surrounded by chlorotic haloes (1-3 mm diameter). These became raised scab-like with age (Fig. 1). To identify causing agent, tissue...
Current methods to remove donor-specific HLA antibody (DSA) from sensitized patients remain imperfect. We tested novel approaches desensitization using an animal model of allogeneic sensitization with skin grafts dark agouti (DA) Lewis rats. At the peak IgG alloantibody response we transplanted DA kidneys into nephrectomized recipients (n = 6) and all died within 10 days antibody-mediated rejection (AMR). Allogeneic hematopoietic stem cell transplants (HSCT) donors failed engraft after...