A5006349554- Advanced Radiotherapy Techniques
- Head and Neck Cancer Studies
- Medical Imaging Techniques and Applications
- Cancer-related molecular mechanisms research
- Radiomics and Machine Learning in Medical Imaging
- Lung Cancer Diagnosis and Treatment
- Oral health in cancer treatment
- T-cell and Retrovirus Studies
- Cancer Diagnosis and Treatment
- Brain Metastases and Treatment
- Head and Neck Surgical Oncology
- Cancer-related gene regulation
- Oral and Maxillofacial Pathology
- Management of metastatic bone disease
- Prostate Cancer Diagnosis and Treatment
- Radiopharmaceutical Chemistry and Applications
- RNA modifications and cancer
- Radiation Therapy and Dosimetry
- Lung Cancer Research Studies
- Surgical site infection prevention
- Esophageal Cancer Research and Treatment
- Circular RNAs in diseases
- Radiation Dose and Imaging
- Sinusitis and nasal conditions
- Salivary Gland Tumors Diagnosis and Treatment
Istituti di Ricovero e Cura a Carattere Scientifico
2021-2023
Centro di Riferimento Oncologico
2022-2023
European Institute of Oncology
2020-2023
Ripamonti
2023
Policlinico Tor Vergata
2017-2019
University of Rome Tor Vergata
2019
The clinical application of different relative biological effectiveness (RBE) models for carbon ion RBE-weighted dose calculation hinders a global consensus in defining normal tissue constraints. This work aims to update the local effect model (LEM)-based constraints rectum using microdosimetric kinetic (mMKM)-defined values, relying on RBE translation and analysis long-term outcomes. LEM-optimized plans treated patients, having suffered from prostate adenocarcinoma (n = 22) sacral chordoma...
Management of head and neck cancers (HNC) in radiation oncology the coronavirus disease 2019 (COVID-19) era is challenging. Aim our work to report organization strategies at a therapy (RT) department first European area experiencing COVID-19 pandemic.We focused on (a) dedicated procedures for HNC, (b) RT scheduling, (c) health care professionals' protection applied during breakdown (from March 1, 2020 April 30, 2020).Applied are reported discussed. Forty-three patients were treated....
Abstract Background and purpose Currently, human papillomavirus (HPV) positivity represents a strong prognostic factor for both reduced risk of relapse improved survival in patients with oropharyngeal squamous cell carcinoma (OPSCC). However, subset HPV-positive OPSCC still experience poor outcomes. Furthermore, HPV-negative patients, who have an even higher relapse, are lacking suitable biomarkers clinical outcome. Here, we evaluated the value LINE-1 methylation level further addressed...
To evaluate the outcome of patients affected by a single isolated body metastasis treated with stereotactic radiotherapy (SBRT).Seven-eight were SBRT for metastasis. The most frequent primary tumor was prostate cancer (28.2%), followed colorectal (23.1%) and lung (20.5%). Median age at diagnosis oligometastatic disease 70 years (range 47-88). Karnofsky Performance Status (KPS) 90 70-100). common fractionation scheme 5 × 7 Gy (total dose 35 Gy). Response to determined according RECIST...
Background: This study investigated the role of depth infiltration (DOI) as an independent prognosticator in early stage (T1-T2N0M0) oral cavity tumors and to evaluate need postoperative radiotherapy case patients upstaged pT3 for DOI > 10 mm absence other risk factors. Methods: We performed a retrospective analysis on treated with surgery re-staged according 8th edition malignant classification (TNM). The well clinical/pathological features was at both univariable multivariable analyses...
The space comprised between tumor and neck lymph nodes (T-N tract) is one of the main routes spread in oral cavity tumors. Aim study was to investigate impact T-N tract involvement on postoperative radiotherapy (PORT) outcomes.Patients (pts) treated 2000 2016 with indication PORT were retrospectively retrieved. Inclusion criteria were: (a) locally advanced tumors cavity, (b) who received (c) a minimum follow-up six months.One hundred fifty-seven pts met inclusion (136 21 not PORT). In...
Aims: To assess whether CT-based radiomics and blood-derived biomarkers could improve the prediction of overall survival (OS) locoregional progression-free (LRPFS) in patients with oropharyngeal cancer (OPC) treated curative-intent RT. Methods: Consecutive OPC primary tumors between 2005 2021 were included. Analyzed clinical variables included gender, age, smoking history, staging, subsite, HPV status, blood parameters (baseline hemoglobin levels, neutrophils, monocytes, platelets, derived...
Abstract Background Radio-chemotherapy with CDDP is the standard for H&N squamous cell cancer. 100 mg/m 2 /q3 standard; alternative schedules are used to reduce toxicity, mostly 40 /q1. Methods Patients were treated from 1/2010 1/2017 in two Radiation Oncology Centres. Propensity score analysis (PS) was retrospectively compare these schedules. Results analyzed 166. Most (114/166) had 1w-CDDP while 52 3w-CDDP. In 3w-CDDP group, patients younger, better performance status, smaller disease...
The last edition of the American Joint Committee on Cancer (AJCC eighth) has introduced depth infiltration (DOI) as a new prognostic parameter in oral cavity squamous cell carcinomas (OCSCCs). aim this study is to analyze impact stage migration indication post-operative radiotherapy (PORT).OCSCCs treated at two institutions between 2014 and 2019 were retrieved. As per AJCC eighth, only pT3 primarily OCSCCs considered; availability pathologic specimen was further inclusion criterion. Risk...
Abstract Background: Currently, human papillomavirus (HPV) positivity represents a strong prognostic factor for both reduced risk of relapse and improved survival in patients with oropharyngeal squamous cell carcinoma (OPSCC). However, subset HPV-positive OPSCC still experience poor outcomes. Furthermore, HPV-negative patients, who have an even higher relapse, are lacking suitable biomarkers clinical outcome. Here, we evaluated the value LINE-1 methylation level further addressed...
_______________________________________________________________________________________________ respectively (Fig Ia and b) Conclusion A combination of radical "adjuvant" radiotherapy in prostate cancer patients with synchronous oligometastatic bony disease at diagnosis surgically managed show promising results terms both biochemical control distant progression-free survival.The only severe event was probably caused by a previously used hypofractionated protocol for prostatic bed irradiation...
Sono stati valutati gli aspetti morfologici delle flogosi croniche rino-sinusali alla TC, eseguita secondo un protocollo iniziale standardizzato, in funzione alterazioni anatomo-patologiche presenti, tenuto conto che le nuove tecniche chirurgiche più conservative presuppongono dettagliato bilancio spaziale pre-operatorio. La TC è tecnica grado di documentare ispessimenti anche minimi della mucosa rino-sinusale, così come manifestazioni reattive ossee tipo litico o sclerotico ed eventuali...
Purpose or ObjectiveRadiation therapy of sinonasal carcinoma (SNC) is challenging to treat due the tumors' location close brain and optical pathways.Proton (PT) may be beneficial, as normal tissue spared, radiation-induced sequelae thus reduced.In order perform proper patient selection evaluate effect future PT, we aimed objectively assess record organ-specific late quality life (QoL) in patients treated with intensity modulated radiotherapy (IMRT) for SNC. Material MethodsA cross sectional...