A5101477165- Radiomics and Machine Learning in Medical Imaging
- MRI in cancer diagnosis
- Endometrial and Cervical Cancer Treatments
- Autophagy in Disease and Therapy
- IgG4-Related and Inflammatory Diseases
- Hepatocellular Carcinoma Treatment and Prognosis
- interferon and immune responses
- Tracheal and airway disorders
- Connexins and lens biology
- Lymphoma Diagnosis and Treatment
- Histiocytic Disorders and Treatments
- Viral-associated cancers and disorders
- Gynecological conditions and treatments
- Nanoplatforms for cancer theranostics
- Endometriosis Research and Treatment
- Ophthalmology and Eye Disorders
- Mitochondrial Function and Pathology
- Urologic and reproductive health conditions
- Neurological Disease Mechanisms and Treatments
- Mesenchymal stem cell research
- Heme Oxygenase-1 and Carbon Monoxide
- Cerebral Venous Sinus Thrombosis
- Advanced MRI Techniques and Applications
- Barrier Structure and Function Studies
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
Tongji University
2025
Shanghai East Hospital
2025
First Hospital of Jilin University
2024
Jilin University
2024
University of Science and Technology of China
2020-2022
Beijing Chest Hospital
2022
Capital Medical University
2022
Anhui Provincial Hospital
2020-2021
Shandong University
2021
Shanghai Institute of Materia Medica
2021
Abstract The autophagic ubiquitin‐like protein LC3 functions through interactions with LC3‐interaction regions (LIRs) of other autophagy proteins, including receptors, which stands out as a promising protein–protein interaction (PPI) target for the intervention autophagy. Post‐translational modifications like acetylation Lys49 on LIR‐interacting surface could disrupt interaction, offering an opportunity to design covalent small molecules interfering interface. Through screening compounds, we...
Background: Cerebral small vessel injury, including loss of endothelial tight junctions, dysfunction, and blood-brain barrier breakdown, is an early typical pathology for Alzheimer's disease, cerebral amyloid angiopathy, hypertension-related disease. Whether there a common mechanism contributing to these cerebrovascular alterations remains unclear. Studies have shown elevation BACE1 (β-site precursor protein cleaving enzyme 1) in vessels from angiopathy or disease patients, suggesting that...
Bronchopleural fistulas (BPFs) are severe medical condition with high mortality. When the conventional surgical therapy failed, endobronchial intervention could function as supplementary option. Several studies reported successful managements of BPFs whereas optimal strategies remain elusive. We retrospectively reviewed records patients underwent interventions Vaseline gauze, shape-adjustable silicone plug, sutured tube or covered metallic stent in our institution. From 2018 to 2024, a total...
Objective This study aimed to assess the predictive value of conventional magnetic resonance imaging (MRI) combined with radiomics in determining nonperfused volume ratio (NPVR) following high-intensity focused ultrasound (HIFU) ablation for uterine fibroids.Methods and materials A total 216 symptomatic fibroids women were subjected HIFU from October 2015 March 2020. Baseline clinical MR parameters acquired before after analyzed, NPVR was calculated accordingly. Radiomics features extracted...
Purpose: To evaluate the diagnostic value combination of whole-tumor dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) and whole-lesion texture features based on T2WI for cervical cancer with parametrial invasion. Materials Methods: Sixty-two patients (27 invasion 35 non-invasion) underwent preoperatively routine MRI sequences DCE-MRI examinations. parameters (Ktrans, Kep, Ve) feature (meanvalue, skewness, kurtosis, uniformity, energy, entropy) were acquired by two observers....
Bedaquiline (Bdq) exerts bactericidal effects against drug-susceptible and drug-resistant Mycobacterium tuberculosis strains, including multidrug-resistant M. strains (MDR-MTBs). However, few reported investigations exist regarding Bdq on MDR-MTBs-infected macrophages activities cytokine secretion. Here, MDR-MTBs related cellular immune mechanisms were explored.Macrophages infected with or H37Rv received treatments (4 h/8 h/24 h/48 h) at 1 × the minimum inhibitory concentration (1 MIC), 10...
This study aims to evaluate the value of 3.0T MRI Intravoxel Incoherent motion diffusion-weighted magnetic resonance imaging (IVIM-DWI) combined with texture analysis (TA) for evaluating extramural vascular invasion (EMVI) rectal adenocarcinoma.Ninety-six patients pathologically confirmed adenocarcinoma after surgical resections were collected. Patients divided into EMVI positive group (n=39) and negative (n=57). We measured IVIM-DWI parameters TA adenocarcinoma. compare differences above...
Primary liver cancer, predominantly hepatocellular carcinoma (HCC), is a leading cause of cancer-related mortality. Tumor thrombus (TT) in the inferior vena cava (IVC) or right atrium (RA) significantly worsens prognosis. We present four cases male patients (average age 57) with HCC and TT extending into IVC/RA, treated at our center. All underwent hepatectomy resection, targeted therapy (lenvatinib) immunotherapy (sintilimab) administered post-operatively. Case 1 involved 59-year-old who...
Abstract Introduction: Benign neoplasm of the endobronchial tree is quite rare, while lipoma extremely rare. Tracheobronchial aspergillosis a relatively uncommon but severe form invasive involving tracheobronchial tree. Patient concerns: A 54-year-old male presented to our hospital for investigation and treatment cough hemoptysis. Diagnosis: The diagnosis was confirmed as with aspergillosis. Interventions: patient received pneumonectomy voriconazole treatment. Outcomes: patient's...
Motivation: To analyze the value of imaging examination in accurate diagnosis breast cancer. Goal(s): Provide an non-invasive for prediction molecular subtypes cancer before treatment. Approach: The quantitative parameters IVIM-DWI and DCE-MRI patients with without any invasive treatment were compared pathological subtypes, so as to their diagnostic subtypes. Results: correlated immune prognostic factors had differential different Impact: could provide a method predicting reference further...
Objective. This study sought to determine the diagnostic value of combined intravoxel incoherent motion (IVIM) diffusion-weighted magnetic resonance imaging (MRI) with diffusion tensor (DTI) in predicting parametrial infiltration (PMI) patients cervical cancer. Materials and Methods. We enrolled 65 cancer confirmed by radical hysterectomy (25 PMI-negative 40 PMI-positive) who underwent IVIM DTI pretreatment. The parameters (ADC, D, D <math xmlns="http://www.w3.org/1998/Math/MathML" id="M1">...
Objective: To discuss the clinical features, imaging pathological patterns, treatment principles and prognosis of orbital nonspecific inflammatory response diseases patients whose CT or MR images show enlargement infraorbital nerves. Methods: A retrospective case series study. Seven disease who were treated at Tianjin Medical University Eye Hospital between March 2013 May 2017 included. All patients, pictures showed nerve. The medical histories, featuers, pathologies, serological...
Objective: To investigate the clinical, imaging and pathological features of adult onset xanthogranuloma. Methods: Retrospective case series study.The clinical data 4 patients with xanthogranuloma treated in Tianjin Medical University Eye Hospital from 2015 to 2017 were analyzed. Results: There 1 male 3 females, aged 46-73 years, an average age 55 years. The duration eyelid swelling was 6 months One binocular cases monocular. progressive enlargement subcutaneous cord nodules poor mobility no...
Objective To observe the protective effect of polypyrimidine bundle-binding protein-related splicing factor (PSF) over-expression on RPE cell injury induced by advanced glycation end products (AGEs). Methods The human cells cultured in vitro were divided into three groups: normal control group (N group), blank + AGEs empty vector (Vec and PSF high expression (PSF AGEs). group). N routinely cultured; only transfected but did not introduce any exogenous genes combined with induction;...
Objective To investigate the inhibitory effect of lentivirus-mediated polypyrimidine bundle binding protein-associated splicing factor (PSF) on retinal neovascularization (RNV) in mice model oxygen-induced retinopathy (OIR). Methods One hundred and twelve 5-day-old C57BL/6J were randomly divided into normal control group, simple OIR + lentivirus empty vector treatment group (Vec group) PSF (PSF group), with 16, 32, 32 mice, respectively. When 7 days old, fed a routine environment, Vec...
Background Pterygium is one of the common ocular surface disorders, and main drugs for pterygium include dexamethasone (DXM), interferon α-2b (IFN-α2b), mitomycin C (MMC), 5-fluorouracil (5-FU), cyclosporin A (CsA) tacrolimus (FK506). However, efficacy these on fibroblasts from recurrence unelucidated. Objective This study was to compare DXM, IFN-α2b, MMC, 5-FU, CsA FK506 proliferation apoptosis recurrent pterygium-derived in vitro. Methods The specimens were collected during...
Objective To evaluate the safety and inductivity of inhaling hypertonic saline in stable patients with interstitial lung disease (ILD). Methods The clinical parameters ILD, including forced expiratory volume one second (FEV1), FEV1%pred, vital capacity (FVC), FVC%pred, blood oxygen saturation, heart rate, were recorded before after 3% hypersonic saline. Results During saline, two ILD experienced excessive bronchoconstriction (defined as a fall FEV1%pred ≥ 20%). The incidence...
Objective To observe the effect of pyrimidine bundle-binding protein-associated splicing factors (PSF) on function hypoxia-induced human retinal microvascular endothelial cells (hRMECs). Methods A three-plasmid system was used to construct lentivirus (LV)-PSF. After LV-PSF infected hRMECs in vitro, infection efficiency measured by flow cytometry. Real-time quantitative PCR (RT-PCR) detect expression PSF mRNA with LV-PSF. The experiment divided into two parts, vivo and vitro. In...
Wei Zhang, Xiuhua Li, Tingting Lin, Fang Ma, Xiaoyu Xiaoli Wu, Yingming Sun, Xiaoge Sun
Abstract The autophagic ubiquitin‐like protein LC3 functions through interactions with LC3‐interaction regions (LIRs) of other autophagy proteins, including receptors, which stands out as a promising protein–protein interaction (PPI) target for the intervention autophagy. Post‐translational modifications like acetylation Lys49 on LIR‐interacting surface could disrupt interaction, offering an opportunity to design covalent small molecules interfering interface. Through screening compounds, we...