A5104387492- Virus-based gene therapy research
- HIV/AIDS Research and Interventions
- Ubiquitin and proteasome pathways
- Lymphoma Diagnosis and Treatment
- Protease and Inhibitor Mechanisms
- Cancer Research and Treatments
- HIV Research and Treatment
- Silkworms and Sericulture Research
- Neurobiology and Insect Physiology Research
- Inflammation biomarkers and pathways
- Viral Infections and Vectors
- Peptidase Inhibition and Analysis
- Genetic Neurodegenerative Diseases
- Ferroptosis and cancer prognosis
- Sepsis Diagnosis and Treatment
- Optimism, Hope, and Well-being
- Single-cell and spatial transcriptomics
- Drug-Induced Hepatotoxicity and Protection
- Oral and gingival health research
- Microtubule and mitosis dynamics
- RNA and protein synthesis mechanisms
- RNA Interference and Gene Delivery
- Cell Adhesion Molecules Research
- Sulfur Compounds in Biology
- Cell Image Analysis Techniques
People's Hospital of Xinjiang Uygur Autonomous Region
2025
Jimei University
2024
Guilin Medical University
2023-2024
Foshan University
2019-2022
Stomatology Hospital
2022
Shenyang Medical College
2022
State Key Laboratory of Oral Diseases
2021
Kunming University of Science and Technology
2017-2021
Sichuan University
2021
Shanghai International Studies University
2020
Abstract The attachment of circulating tumor cells to the blood vessels distant organs is an important step in metastasis. We show here that experimental lung metastasis by two cell lines, B16F1 melanoma and 3LL carcinoma, greatly reduced transgenic mice lack plasma fibronectin. This multifunctional adhesive glycoprotein becomes cross-linked fibrin during clotting. Here, we report eliminating fibronectin from circulation reverses prometastatic effects clotting integrin αvβ3. In vitro studies...
Abstract The ability of cancer cells to evade apoptosis may permit survival a recombinant vaccinia lacking antiapoptotic genes in compared with normal cells. We have explored the deletion two virus host range/antiapoptosis genes, SPI-1 and SPI-2, for their effects on viral replication induce cell death infected transformed vitro. Indeed, three paired types, SPI-2 gene-deleted (vSP) preferentially replicates or p53-null when counterparts. This selectivity be derived from fact that...
Introduction Burn-induced sepsis is a critical clinical challenge marked by systemic inflammation, immune dysregulation, and high mortality. Macrophage-driven inflammatory pathways are central to pathogenesis, while cell metabolic reprogramming plays key role in both cancer progression. Methods Bioinformatics analyses using GEO, TCGA, GTEx datasets identified MLIP-modulated genes linked responses prognosis. In vitro , LPS-stimulated HUVEC cells were used study MLIP’s effects on inflammation...
Over-expression of AURKC has been detected in human colorectal cancers, thyroid carcinoma and several cancer cell lines. However, the regulation clinical implications over-expressed cells are unclear. Here we show that elevated increases proliferation, transformation migration cells. Importantly, kinase activity is required for these tumour-associated properties. Analysis specimens shows expression increased cervical cancer, highly correlated with staging cancer. Over-expressed AURKC-GFP...
Abstract OBJECTIVE The disinfection efficiency of disinfectants differs in specific conditions. This study aimed to investigate the commercial hydrogen peroxide, chlorine dioxide, and disinfectant on real field surfaces provide data for precise disinfection. METHODS Simulated methods were conducted quantitatively evaluate sodium dichloroisocyanurate. log 10 reduction biological indicators, Escherichia coli (ATCC 8099) Staphylococcus aureus 6538), was calculated. Next, natural bacteria a food...
The overall success of Human immunodeficiency virus type 1 (HIV-1) antiretroviral therapy (ART) was heavily challenged upon the occurrence drug resistance. Dehong Prefecture witnessed not only first report HIV-1 infection but also experimental adoption antiviral treatment in China. transmission and epidemic is impacted by cross-border activities. characteristics resistance among therapy-naïve Burmese entering travelers Yunnan their speculated origin are still clarified. Two hundred...
Abstract Background With the framework of mindset theory and previous findings in adult criminal justice, this research explores how growth mindset—the belief that personal traits are malleable—affects judicial decision‐making juvenile justice. Aims We aim to examine hypotheses laypeople with tend endorse more rehabilitative motivations decisions (H1) through reduced trait attribution (H2). Materials Methods measured (Study 1) experimentally manipulated 2) test H1 H2 samples laypeople....
The acute liver injury model of mice induced by carbon tetrachloride (CCl<sub>4</sub>) was used to explore the protective effect aqueous extract Spatholobi Caulis on injury. Methods: contents total phenols and flavonoids in ethanol extracts spatholobi were determined, antioxidant activity evaluated DPPH, ABTS free radical scavenging rate FRAP reducing capacity. 30 C57BL/6J male randomly divided into group, bifendate low-dose, medium-dose high-dose groups (n = 6). animal established...
7-Difluoromethyl-5, 4’-dimethoxygenistein (DFMG), prepared by the difluoromethylation and alkylation of Genistein, is a new active chemical entity. In this study, we investigated inhibitory effect DFMG on Lysophosphatidyl choline (LPC)-induced apoptosis human umbilical vein endothelial cells-12 (HUVEC-12) through mitochondrial pathway. (LPC) was used to build model in HUVEC-12 cells. The rate each group determined using flow cytometry ANNEXIN V/PI staining. mean ffluorescence intensity (MFI)...
Sexual transmission is currently the main mode of human immunodeficiency virus (HIV). In this study, 181 HIV-infected female cross-border travelers entering Yunnan province were recruited between 2003 and 2012. HIV RNAs extracted from their frozen serum gag-pol gene sequences obtained for phylogenetic recombination analyses. total, 131 successfully, at a rate 72.4%. The most prevalent subtypes CRF01_AE, followed by CRF08_BC, B C. other four subjects classified as undefined recombinants....
Spinocerebellar ataxia type 17 (SCA17) involves the expression of a polyglutamine-expanded TATA box binding protein (TBP), general transcription initiation factor. TBP interacts with other factors, including high mobility group 1 (HMGB1), to regulate gene expression. In this study, we examined effect Q-tract length on HMGB1 using recombinant and N-terminal TBP/Q20~61 proteins. The intracellular association was first confirmed by half-in vivo co-immunoprecipitation (co-IP) glutathione...
Objective To investigate the characteristics of epidemic and genotype/subtype distribution hepatitis C virus (HCV) among entry travelers at Tengchong port, to provide references for HCV prophylaxis treatment. Methods A total 54 serum samples were collected from anti-HCV positive port June 2009 2016. NS5B gene was amplified using reverse transcription polyonerase chain reation (RT-PCR) subsequently sequenced. Based on obtained sequences retrieved reference sequences, phylogenetic...
Abstract Background Lymphoma is accompanied by multiple immune functions impairment. Cytokines play an important role in a variety of immune-related and affect the tumor microenvironment. However, exact regulatory mechanisms between them remains unclear. This study aimed to explore cytokines expression function Hodgkin's lymphoma (HL), diffuse large B-cell (DLBCL) mantle cell (MCL). Results We performed transcriptome integration analysis 14 datasets including 240 lymphoma, 891 216 64 health...
Lymphoma is accompanied by the impairment of multiple immune functions. Cytokines play an important role in a variety immune-related functions and affect tumor microenvironment. However, exact regulatory mechanisms between them remain unclear. This study aimed to explore cytokines expression function Hodgkin's lymphoma (HL), diffuse large B-cell (DLBCL), mantle cell (MCL). We performed transcriptome integration analysis 14 datasets including 240 lymphoma, 891 216 64 health samples. The...