A5101940682- Anesthesia and Sedative Agents
- Cardiac Arrest and Resuscitation
- Anesthesia and Pain Management
- Thermal Regulation in Medicine
- Trauma and Emergency Care Studies
- Disaster Response and Management
- Anesthesia and Neurotoxicity Research
- Cardiac, Anesthesia and Surgical Outcomes
- Analytical Chemistry and Sensors
- Sepsis Diagnosis and Treatment
- Nausea and vomiting management
- Musculoskeletal pain and rehabilitation
- Meningioma and schwannoma management
- Head and Neck Surgical Oncology
- Cancer Cells and Metastasis
- Cancer Immunotherapy and Biomarkers
- Veterinary Pharmacology and Anesthesia
- Ovarian cancer diagnosis and treatment
- Teratomas and Epidermoid Cysts
- Blood properties and coagulation
- Infective Endocarditis Diagnosis and Management
- Health and Wellbeing Research
- Intensive Care Unit Cognitive Disorders
- Pain Management and Treatment
- Chemokine receptors and signaling
Pusan National University
2009-2024
Mayo Clinic in Florida
2021-2023
Neurological Surgery
2023
WinnMed
2023
University of California, Irvine
2023
Johns Hopkins University
2023
CHA Bundang Medical Center
2021-2023
University of Bradford
2023
CHA University
2020-2022
National Medical Center
2020-2022
Apigenin, a flavonoid abundant in various vegetables and fruits, including parsley onions, has been reported to possess anticarcinogenic effects. However, the direct molecular target of apigenin its chemopreventive effect on ultraviolet (UV)-induced skin inflammation are not understood fully. Herein, we examined anti-inflammatory associated mechanisms JB6 P+ cell line SKH-1 hairless mouse model. Apigenin inhibited UVB-induced cyclooxygenase-2 (COX-2) expression, which is well-known key...
Peritoneal carcinomatosis (PC) is a common and devastating manifestation of colon cancer refractory to conventional anticancer therapeutics. During the peritoneal dissemination cancer, immunity nullified by various mechanisms immune evasion. Here, we employed armed oncolytic vaccinia virus mJX-594 (JX) rejuvenate antitumor responses in treatment PC.PC model MC38 was generated intraperitoneally treated with JX and/or anti-programmed cell death protein 1 (PD-1) antibody. The tumor burden,...
Understanding cancer heterogeneity is essential to finding diverse genetic mutations in metastatic cancers.Thus, it critical isolate all types of CTCs identify accurate information from patients.Moreover, full automation robustly capturing the spectrum an urgent need for CTC diagnosis be routine clinical practice.Methods: Here we report capture heterogeneous populations using fully automated, negative depletion-based continuous centrifugal microfluidics (CCM).Results: The CCM system...
4-Hydroxynonenal (HNE) mediates oxidative stress-linked pathological processes; however, its role in the generation of reactive oxygen species (ROS) macrophages is still unclear. Thus, this study investigated sources and mechanisms ROS stimulated with HNE. Exposure J774A.1 cells to HNE showed an increased production ROS, which was attenuated by NADPH oxidase as well 5-lipoxygenase (5-LO) inhibitors. Linked these results, membrane translocation p47phox promoting activity, peritoneal from...
Renal cell carcinoma (RCC) is the most common type of kidney malignancy worldwide with Pembrolizumab and axitinib treatment (Pembro/Axi) amongst effective first-line immunotherapies for advanced RCC. However, it remains difficult to predict response early resistance. Therefore, we evaluated whether baseline serum interleukin-6 (IL-6) could be a predictive biomarker. Between November 2019 December 2021, 58 patients RCC were enrolled, administered Pembro/Axi, blood samples analyzed using flow...
We investigated the association between lactate clearance or serum levels and neurologic outcomes in-hospital mortality in cardiac arrest survivors who were treated with targeted temperature management (TTM).A retrospective analysis of data from TTM 2012 2015 was conducted. Serum measured on admission at 12, 24, 48 hours following admission. Lactate also calculated. The primary outcome discharge. secondary mortality.The study included 282 patients; 184 (65.2%) discharged a poor outcome, 62...
A hyaluronic-acid-rich node and duct system (HAR-NDS) was found on the surface of internal organs mice, inside their blood lymph vessels. The nodes (HAR-Ns) were filled with immune cells innate especially enriched mast histiocytes. They also contained hematopoietic progenitor (HPCs), such as granulocyte-macrophage, erythroid, multipotential progenitors, cell progenitors (MCPs). MCPs most abundant among HPCs in HAR-Ns. Their frequency fivefold higher than that bone marrow. In addition,...
The preventable trauma death rate survey is a basic tool for the quality management of treatment because it method that can intuitively evaluate level national treatment. We conducted this study as biennial follow-up project and report results review 2019 data in Korea.
A 61-year-old man who had been diagnosed with prostate cancer 9 years ago and treated pelvic irradiation intermittent androgen deprivation therapy visited the emergency room because of back pain weakness in both legs.Spine magnetic resonance imaging showed a lumbar epidural mass spine metastasis.The whole-body workup revealed multiple metastases to lymph nodes, bone, liver, lung.The serum prostate-specific antigen was 0.02 ng/ml.He underwent laminectomy, posterior fixation, excision,...
Platelet-activating factor (PAF), 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine, is a potent phospholipid mediator and has been reported to be localized in atherosclerotic plaque. However, its role the progression of atherosclerosis remains unclear. In present study, we investigated PAF production matrix metalloproteinase (MMP) primary vascular smooth muscle cells (VSMCs). When rat aortic VSMCs were stimulated with (1 nmol/l), expressions MMP-2 mRNA protein, but not MMP-9, significantly...
Glucocorticoids are commonly used as palliative or chemotherapeutic clinical agents for treatment of a variety cancers. Although steroid is beneficial, the mechanisms by which steroids improve outcome in cancer patients not well understood. Na,K-ATPase beta-subunit isoform 1 (NaK-β1) cell-cell adhesion molecule, and its expression down-regulated cells undergoing epithelial-to mesenchymal-transition (EMT), key event associated with progression to metastatic disease. In this study, we...