A5062226167- Pluripotent Stem Cells Research
- Hippo pathway signaling and YAP/TAZ
- Cardiomyopathy and Myosin Studies
- Pancreatic function and diabetes
- Metabolism, Diabetes, and Cancer
- Diabetes Treatment and Management
- Ion channel regulation and function
- Cardiac electrophysiology and arrhythmias
- Synthesis and Biological Evaluation
- Cardiovascular Effects of Exercise
- Nitric Oxide and Endothelin Effects
- Receptor Mechanisms and Signaling
- Computational Drug Discovery Methods
- Semiconductor materials and devices
- Pain Mechanisms and Treatments
- Neuroscience and Neural Engineering
- Cardiac Fibrosis and Remodeling
- Phytochemicals and Antioxidant Activities
- Chemical Synthesis and Analysis
- Ion Channels and Receptors
- Cancer therapeutics and mechanisms
- Advanced biosensing and bioanalysis techniques
University of Milano-Bicocca
2022-2024
Leiden University Medical Center
2022
University of Pavia
2022
Abstract Background Glucagon like peptide-1 receptor agonists (GLP-1RAs) have shown to reduce mortality and cardiovascular events in patients with type 2 diabetes mellitus (T2DM). Since the impairment number function of vasculotrophic circulating CD34 + hematopoietic stem progenitor cells (HSPCs) T2D has been reported increase (CV) risk, we hypothesized that one mechanisms whereby GLP-1 RAs exert CV protective effects may be related ability improve HSPC function. Methods In cord blood...
Rationale: Aging in the heart is a gradual process, involving continuous changes cardiovascular cells, including cardiomyocytes (CMs), namely cellular senescence.These finally lead to adverse organ remodeling and resulting failure.This study exploits CMs from human induced pluripotent stem cells (iCMs) as tool model characterize mechanisms involved aging.Methods Results: Human somatic were reprogrammed into subsequently differentiated iCMs.A senescent-like phenotype (SenCMs) was by short...
Striatin (Strn) is a scaffold protein expressed in cardiomyocytes (CMs) and alteration of its expression are described various cardiac diseases. However, the underlying pathogenicity have been poorly investigated.
(1) Background: Store-operated Ca2+ entry (SOCE) drives the cytotoxic activity of T lymphocytes (CTLs) against cancer cells. However, SOCE can be enhanced in cells due to an increase expression and/or function its underlying molecular components, i.e., STIM1 and Orai1. Herein, we evaluated tumour-infiltrating (TILs) from metastatic colorectal (mCRC) patients. (2) Methods: Functional studies were conducted TILs expanded ex vivo CRC liver metastases. Peripheral blood healthy donors (hPBTs)...
Abstract Background Perspective regenerative therapies for injured myocardium focus on reactivating developmental processes to regenerate damaged contractile tissue. In animal models, the Hippo pathway was shown improve heart regeneration after myocardial infarction, possibly by expanding pool of cardiomyocytes. We hypothesized that activating pathway’s downstream effector, Yes Associated Protein (YAP1), may have effects beyond promoting proliferation in human therefore investigated how YAP1...
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