A5073727992- Diabetes Treatment and Management
- Fatty Acid Research and Health
- Pancreatic function and diabetes
- Metabolism, Diabetes, and Cancer
- Chronic Kidney Disease and Diabetes
- Diet and metabolism studies
- Lipid metabolism and biosynthesis
- Hormonal Regulation and Hypertension
- Clinical Nutrition and Gastroenterology
- Renal and related cancers
- Marine and fisheries research
- Genetic and Kidney Cyst Diseases
- Fish Biology and Ecology Studies
- Birth, Development, and Health
- Renin-Angiotensin System Studies
- Balance, Gait, and Falls Prevention
- Inflammatory mediators and NSAID effects
- Amino Acid Enzymes and Metabolism
- Artificial Intelligence in Healthcare
- Electrolyte and hormonal disorders
- Ion Transport and Channel Regulation
- Acute Kidney Injury Research
- Maritime Navigation and Safety
- Adipose Tissue and Metabolism
- Aquatic Ecosystems and Biodiversity
Gubra (Denmark)
2021-2025
ALK-Abelló (Denmark)
2025
University of Delaware
2020-2023
DHI
2021-2022
Aarhus University
1977-2020
Aarhus University Hospital
2013-2015
Springhouse
2012
Novo Nordisk (Denmark)
1993-2010
University of Southern Denmark
2008
Kurukshetra University
2008
Significance Millions of people worldwide suffer from chronic nasal inflammation involving obstructed airflow and discharge. Although is often considered to be a reaction allergens, approximately one-quarter all cases are nonallergic rhinitis. The causes this disease unknown, but symptoms may triggered or exacerbated by variety inhaled irritants even seemingly innocuous odors. We report here that specialized chemosensory cells the epithelium mice detect potential transmit information...
A data set consisting of 712 compounds was used for classification into two classes with respect to membrane permeation in a cell-based assay: (0) apparent permeability (P(app)) below 4 x 10(-6) cm/s and (1) P(app) on or higher. Nine molecular descriptors were calculated each compound Nearest-Neighbor applied using five neighbors as optimized by full cross-validation. model based descriptors, number flex bonds, hydrogen bond acceptors donors, polar surface area, selected variable selection....
Although T lymphocytes are present in the genital mucosa, their function sexually transmitted diseases is unproven. To determine if cervical cells mediate HIV-specific cytolysis, mononuclear cytobrush specimens from HIV-1-infected women were stimulated vitro with antigen. Resultant cell lines lysed autologous targets expressing HIV-1 proteins 12/19 (63%) subjects, and these responses detected intermittently on repeated visits. All 8 subjects blood CD4+ counts ⩾500 cells/μl had HIV-1-specific...
Reversible phosphorylation and dephosphorylation of key proteins on tyrosine residues are important parts intracellular signaling triggered by hormones other agents. Recent knock-out studies in mice have identified PTP1B as a potential target for the treatment diabetes obesity. As consequence, number academic industrial groups aggressively pursuing development selective inhibitors. In addition, protein-tyrosine phosphatases (PTPs) appear to be critically involved major diseases such cancer...
The characteristics of the inducible galactose system in Saccharomyces cerevisiae were studied by using nonmetabolized analogues, l -arabinose and d -fucose, galactokinaseless transportless mutants. Induced wild-type cells transport facilitated diffusion. Transportless neither nor above noninduced rate, whereas -fucose Determination unidirectional rate 14 C-labeled uptake preloaded cells, containing a large unlabeled free-galactose pool, showed that diffusion is greater than metabolism at...
Renal fibrosis plays a pivotal role in the development and progression of chronic kidney disease, which affects 10% adult population. Previously, it has been demonstrated that cyclooxygenase-2 (COX-2)/prostaglandin (PG) system influences renal injury. Here, we evaluated impact butaprost, selective EP2 receptor agonist, on several models injury, including human tissue slices.We studied anti-fibrotic efficacy butaprost using Madin-Darby Canine Kidney (MDCK) cells, mice underwent unilateral...
Abstract Background Extensive preclinical research aims to develop novel therapeutics for myocardial fibrosis (MF), a condition marked by collagen accumulation that impairs cardiac function. MF is particularly relevant in heart failure with preserved ejection fraction (HFpEF), growing clinical challenge limited treatment options. However, current methods quantifying mouse models struggle accurately capture its heterogeneous regional distribution, creating significant barrier reliably...
Background: Obesity, hyperglycemia and hypertension are critical risk factors for development of diabetic kidney disease (DKD). Emerging evidence suggests that glucagon-like peptide-1 receptor (GLP-1R) agonists improve cardiovascular renal outcomes in type 2 diabetes patients. Here, we characterized the effect long-acting GLP-1R agonist semaglutide alone combination with an ACE inhibitor (lisinopril) a model hypertension-accelerated, advanced DKD facilitated by adeno-associated...
Abstract The type-2 diabetes drug metformin has proven to have protective effects in several renal disease models. Here, we investigated the a 3-day unilateral ureteral obstruction (3dUUO) mouse model. Compared with controls, obstructed animals displayed increased tubular damage and inflammation. Metformin treatment attenuated inflammation, anti-oxidative response decreased damage. Hepatic uptake depends on expression of organic cation transporters (OCTs). To test whether kidney are...
Translational animal models of diabetic kidney disease (DKD) are important tools in preclinical research and drug discovery. Here, we show that standard care to control hypertension (lisinopril) hyperglycemia (empagliflozin) improves physiological histopathological hallmarks a mouse model hypertension-accelerated progressive DKD. The findings substantiate type 2 diabetes as essential factors driving DKD progression, provide proof-of-concept for probing novel drugs potential nephroprotective...
Fat absorption may be compromised by pancreatic or bile insufficiency, resulting in low uptake of essential fatty acid and energy. Using a rat model malabsorption, we examined the defined triglycerides with medium-chain acids (MCFA) sn-1,3 positions sn-2 position (MLM) compared to other fats. The thoracic duct was cannulated for collection lymph, common divert both juice bile. rats were given single bolus triglyceride as taurocholate emulsion. measured from collected lymph samples....
Plasma catecholamines were measured by employing a precise and sensitive double-isotope technique in 9 control subjects 20 patients with various types of hypertension. Venous blood was collected while the rested supine position. In total plasma catecholamine concentration averaged 0.25 ng/ml ± 0.08. The noradrenaline 0.21 adrenaline 0.05 ng/ml. Total normal renal essential hypertension 4 phaeocromocytoma showed values ranging from 0.48 to 7.90
Oxidative stress resulting from unilateral ureteral obstruction (UUO) may be aggravated by increased production of ROS. Previous studies have demonstrated cyclooxygenase (COX)-2 expression in renal medullary interstitial cells (RMICs) response to UUO. We investigated, both vivo and vitro, the role ROS induction COX-2 rats subjected UUO RMICs exposed oxidative mechanical stress. Rats 3-day were treated with two mechanistically distinct antioxidants, NADPH oxidase inhibitor diphenyleneiodonium...
Abstract We investigated the influence of intramolecular fatty acid distribution dietary triacyl‐ sn ‐glycerols (TAG) rich in n‐3 polyunsaturated acids (PUFA) on structure chylomicron TAG. Fish oil and seal oil, comparable compositions but with different contents major PUFA esterified at ‐2 position (20:5n‐3, 46.6%, 5.3%; 22:6n‐3, 75.5%, 3.8%, respectively), were fed to rats. Mesenteric lymph was collected chylomicrons isolated by ultracentrifugation. The composition largely reflected oils...
Yeast membrane vesicles are formed when packed yeast ground manually in a porcelain mortar and pestle with glass beads (0.2 mm diameter). These can be separated from the other components of grinding mixture by combination centrifugation steps elution column same Isolated osmotically sensitive, contain cytoplasmic components, have energy-independent transport function. They unable to metabolize glucose, but respiratory function which is thought associated intravesicular mitochondria....
Repaglinide is a novel insulin secretagogue developed in response to the need for fast‐acting, oral prandial glucose regulator treatment of type 2 (non‐insulin‐dependent) diabetes mellitus. metabolized mainly liver; its pharmacokinetics may therefore be altered by hepatic dysfunction. This open, parallel‐group study compared and tolerability single 4 mg dose repaglinide healthy subjects (n = 12) patients with chronic liver disease (CLD) 12). Values AUC C max were significantly higher CLD...
Abstract Background The purpose of the study is to examine effect metformin on oxygen metabolism and mitochondrial function in kidney an animal model insulinopenic diabetes order isolate any renoprotective from concomitant blood glucose homeostasis. Methods Sprague‐Dawley rats were injected with streptozotocin (STZ) (50 mg kg −1 ) when stable started treatment (250 drinking water. Rats prepared for vivo measurements 25 30 days after STZ injection, where renal function, including glomerular...
Metformin is today the first choice treatment for type-2 diabetes, but has also protective effects in several renal disease models. Previously, we have demonstrated that response to unilateral ureteral obstruction (UUO) are independent of organic cation transporters (OCTs), responsible metformin uptake into cells. The mechanisms behind renoprotective incompletely understood, our previous results indicate at least partly could be dependent on actions outside In this study, investigate whether...
Summary Clearance mechanisms for recombinant activated human FVII (rFVIIa; NovoSeven®), a heterogeneously glycosylated protein, have yet to be fully elucidated, but may involve the liver. The effects of γ-carboxy glutamic acid (Gla) domain and sialic content protein on rFVIIa clearance were investigated following intravenous administration lacking Gla domain, des(1–44) asialo-rFVIIa in pharmacokinetic (PK) studies perfused rat livers. PK parameters both had similar biphasic profiles, as well...
Summary Background P ropionibacterium acnes is a major contributing factor to the inflammatory component of acne. The interaction . with keratinocytes leads an innate immune response via activation toll‐like receptors ( TLR 2, 4) resulting in production and secretion pro‐inflammatory mediators. SIG 1273, isoprenylcysteine small molecule modulates signaling pathways kills 1273 represents novel cosmetic functional ingredient that provides relief from blemishes acne prone skin. Objective To...