A5087864448- Inflammatory Bowel Disease
- Colorectal Cancer Surgical Treatments
- IL-33, ST2, and ILC Pathways
- Hernia repair and management
- Cardiac, Anesthesia and Surgical Outcomes
- Lipid metabolism and disorders
- Adipokines, Inflammation, and Metabolic Diseases
- Autoimmune and Inflammatory Disorders
- Anorectal Disease Treatments and Outcomes
- Global Health and Surgery
- Stoma care and complications
- Biochemical Analysis and Sensing Techniques
- Biomarkers in Disease Mechanisms
- Pelvic and Acetabular Injuries
- Cancer Treatment and Pharmacology
- Colorectal Cancer Screening and Detection
- Inflammation biomarkers and pathways
- Pelvic floor disorders treatments
- Pancreatic and Hepatic Oncology Research
- COVID-19 and healthcare impacts
- Management of metastatic bone disease
- Abdominal Surgery and Complications
- Ion Channels and Receptors
- Microscopic Colitis
- Intestinal and Peritoneal Adhesions
Hospital Universitari Joan XXIII de Tarragona
2019-2024
Institut d'Investigació Sanitària Pere Virgili
2021-2024
Universidad Rovira i Virgili
2023
Crohn's disease [CD] is associated with complex microbe-host interactions, involving changes in microbial communities, and gut barrier defects, leading to the translocation of microorganisms surrounding adipose tissue [AT]. We evaluated presence beige AT depots CD questioned whether succinate and/or bacterial promotes white-to-beige transition adipocytes.Visceral [VAT] subcutaneous [SAT] biopsies, serum plasma were obtained from patients active [n = 21] or inactive 12] CD, healthy controls...
Abstract Background and Aims Crohn’s disease [CD] is characterised by the expansion of mesenteric adipose tissue [MAT], named creeping fat [CF], which seems to be directly related activity. Adipose-stem cells [ASCs] isolated from CF patients with CD are extremely pro-inflammatory, persists during remission. We hypothesised that dysfunctional ASCs in accumulate epigenetic modifications triggered inflammatory environment, could serve as molecular markers. Methods Genome-wide DNA methylome...
Crohn's disease (CD) is characterized by compromised immune tolerance to the intestinal commensal microbiota, barrier inflammation, and hyperplasia of creeping fat (CF) mesenteric adipose tissue (AT), which seems be directly related activity. Gut microbiota dysbiosis might a determining factor in CD etiology, manifesting as low microbial diversity high abundance potentially pathogenic bacteria. We tested hypothesis that CF reservoir bacteria through 16S-rRNA sequencing several AT depots...
Some beneficial effects of grape seed proanthocyanidin extract (GSPE) can be explained by the modulation enterohormone secretion. As GSPE comprises a combination different molecules, pure compounds that cause these need to elucidated. The enterohormones and chemoreceptors present in gastrointestinal tract differ between species, so if humans are gain effects, species closer humans—and themselves—must used. We demonstrate 100 mg/L stimulates peptide YY (PYY) release, but not glucagon-like 1...
Colorectal cancer is the second most frequent in Western world. A third of colorectal tumors are located right colon, and hemicolectomy treatment nondisseminated colon cancer. The serious complication this procedure anastomotic leak, which occurs 8.4% cases. At present, there no standardized technique for laparoscopic ileo-colic anastomosis. In previous observational studies, intracorporeal side-to-side anastomosis has shown better results than extracorporeal terms morbidity mortality. It...
Anti-TNF biologics have been shown to markedly improve the quality of life for patients with Crohn's disease (CD), yet one-third fail benefit from this treatment. Patients CD develop a characteristic wrapping visceral adipose tissue (VAT) in inflamed intestinal area, termed creeping fat, and it is known that expansion influences efficacy anti-TNF drugs. We questioned whether therapies impact fat CD, which might affect outcome disease. Adipose biopsies were obtained cohort 14 received drugs...
Abstract To test the efficacy and safety of phenolization in uncomplicated Sacrococcygeal pilonidal disease (SPD) SPD is feasible secure selected patients observational studies. The greatest benefits are obtained to reduce length sick leave (LSL) complications. Single‐center randomised controlled clinical trial. Patients were recruited at University Hospital Tarragona Joan XXIII Spain. into two treatment groups. All with sacrococcygeal disease, localised midline only 1 fistulous orifice....
Patients with Crohn’s disease (CD) who smoke are known to have a worse prognosis than never-smokers and higher risk for post-surgical recurrence, whereas patients quit smoking after surgery significantly lower post-operative recurrence. The hypothesis was that induces epigenetic changes impair the capacity of adipose stem cells (ASCs) suppress immune system. It also questioned whether this impairment remains in ex-smokers CD. ASCs were isolated from non-smokers, smokers CD their interactions...
GLP1 produced in the upper part of gut is released after food intake and acts by activating insulin secretion, but role colon, where it predominantly produced, remains unknown. Here we characterized apical versus basolateral secretion PYY paracrine mechanisms action these enterohormones human colon. We stimulated colon tissue different ex vivo models with meat peptone used immunofluorescence to study presence canonical non-canonical receptors GLP1. found that are secreted mainly at lumen...
Purpose: The simultaneous repair of incisional hernias (IH) and the reconstruction intestinal transit may pose a challenge for many surgeons. Collaboration between units specialized in abdominal wall colorectal surgery can favor treatment. Methods: Descriptive study patients undergoing complex IH from start treatment joint team. All interventions were performed electively with collaboration surgeons experts surgery. Results: 23 are included. 11 end colostomies, 1 loop colostomy, 6...
Abstract Background Crohn’s disease (CD) is characterised by expansion of mesenteric adipose tissue, called creeping fat, which seems to be directly related activity. Adipose stem cells (ASCs) isolated from the fat CD patients exhibit dysfunction, featuring impaired adipogenesis and an intensely pro-inflammatory phenotype. This study aims explore transcriptome ASCs active inactive subjects in comparison with healthy subjects, seeking key markers this dysregulation. Methods Patients were...
Abstract Background Crohn’s disease (CD) is characterized by persistent inflammation and ulcerations at the small or large bowel, provoking chronic low-grade systemic inflammation. Adipose tissue (AT) believed to play an active role in pathogenesis of CD, as expansion mesenteric fat attached inflamed segments intestine, also known “creeping fat,” a hallmark that seems be directly related activity. We demonstrated adipose-stem cells (ASC) isolated from creeping CD patients showed...
Abstract Background Crohn’s disease (CD) is characterized by the expansion of mesenteric fat attached to inflamed segments intestine, also known as “creeping fat” which seems be directly related activity. Our group revealed that adipose-stem cells (hASCs) isolated from creeping CD subjects are dysfunctional (showing a high inflammatory profile, invasive and phagocytic capacities, worse immunosuppressive properties); this dysfunction maintained even in hASCs remission disease.1 Methods 1)...
Abstract Background Crohn’s disease (CD) is characterized by severe transmural inflammation with subsequent destruction of the intestinal barrier. Bacterial infiltration across this leaky gut facilitates access to mesenteric fat and development a inflammatory reaction in surrounding adipose tissue named creeping (CF). Dysbiosis CD patients has been associated an increase succinate-producing bacteria decrease succinate-consuming bacteria. In fact, elevated succinate levels have found...
Abstract Aim The simultaneous repair of incisional hernias (IH) and the reconstruction intestinal transit may pose a challenge for many surgeons. Collaboration between units specialized in abdominal wall colorectal surgery can favor treatment. We present our experience collaboration treatment complex ostomy closure. Material Methods Descriptive study patients undergoing IH period 2018.2021. All interventions were performed electively with surgeons experts surgery. Demographic variables,...