A5027548412- Nosocomial Infections in ICU
- Central Venous Catheters and Hemodialysis
- Tracheal and airway disorders
- Esophageal and GI Pathology
- Sepsis Diagnosis and Treatment
- Pelvic floor disorders treatments
- Neonatal and Maternal Infections
- Dysphagia Assessment and Management
- Monoclonal and Polyclonal Antibodies Research
- Infective Endocarditis Diagnosis and Management
- Neuroblastoma Research and Treatments
- Cancer Cells and Metastasis
- Foreign Body Medical Cases
- Management of metastatic bone disease
- Surgical site infection prevention
- T-cell and B-cell Immunology
- Family and Patient Care in Intensive Care Units
- Sarcoma Diagnosis and Treatment
- Neuroendocrine Tumor Research Advances
- Pancreatic function and diabetes
- Injury Epidemiology and Prevention
- Diabetes Management and Research
- Dialysis and Renal Disease Management
- Diabetes and associated disorders
- Hernia repair and management
Cincinnati Children's Hospital Medical Center
2014-2022
Center for Children
2021
OBJECTIVE The autoimmune destruction of β-cells in type 1 diabetes results a loss insulin production and glucose homeostasis. As such, an immense interest exists for the development therapies capable attenuating this destructive process through restoration proper immune recognition. Therefore, we investigated ability immune-depleting agent antithymocyte globulin (ATG), as well mobilization granulocyte colony–stimulating factor (GCSF), to reverse overt hyperglycemia nonobese diabetic (NOD)...
Abstract Background Image‐guided percutaneous core needle biopsy (PCNB) is increasingly utilized to diagnose solid tumors. The objective of this study determine whether PCNB adequate for modern biologic characterization neuroblastoma. Procedure A multi‐institutional retrospective was performed by the Pediatric Surgical Oncology Research Collaborative on children with neuroblastoma at 12 institutions over a 3‐year period. Data collected included demographics, clinical details, technique,...
Prophylactic ethanol lock therapy (ELT) reduces central line-associated bloodstream infections (CLA-BSIs) in children with intestinal failure (IF). However, the risk of associated complications is unclear. We aim to describe our experience prophylactic locks a cohort patients IF.Thirty on ELT from 2010-2013 were identified by review rehabilitation registry. Patient demographics, CLA-BSI events, and line extracted. Comparisons infection complication rates when off made using Poisson...
Fc receptors are a critical component of the innate immune system responsible for recognition cross-linked antibodies and subsequent clearance pathogens. However, in autoimmune diseases, these play role deleterious action self-directed as such candidate targets treatment. GMA161 is an aglycosyl, humanized version murine antibody 3G8 that human low-affinity Fcγ receptor III (CD16). As CD16 expression sequence have high species specificity, preclinical assessments were conducted mice...
Objective: To determine the impact of tumor characteristics and treatment approach on (1) local recurrence, (2) scoliosis development, (3) patient-reported quality life in children with sarcoma chest wall. Summary Background Data: Children wall require multimodal therapy including chemotherapy, surgery, and/or radiation. Despite aggressive which places them at risk for functional impairment scoliosis, these patients are also significant recurrence. Methods: A multi-institutional review 175...
Background: Central line–associated bloodstream infections (CLABSIs) pose a significant challenge in the lives of patients with intestinal failure (IF). We hypothesized that plasma immunoglobulins against flagellin (FLiC) and lipopolysaccharide (LPS) would be able to differentiate CLABSIs from nonbacterial febrile episodes levels increase infection decline following appropriate antibiotic treatment. Materials Methods : Patients IF, due short bowel syndrome, between ages 3 months 4 years age,...
Pediatric intestinal failure (IF) patients experience significant morbidity, including sepsis related to central line-associated bloodstream infections. Adult studies of demonstrate an association between time antibiotic administration (TTA) and mortality. To overcome challenges in treating pediatric IF emergency department (ED), we appropriated existing, reliable system for febrile immunocompromised oncology/bone marrow transplant children. We describe the translation this process ED steps...
Appropriate and timely triage is an essential component of a trauma system. In the state Ohio, there are 6 verified pediatric centers (PTCs) across 8 regions. The purpose this study was to better understand undertriage rates in state.We used Ohio Trauma Registry from 2007 2012, consisting 14,045 records children younger than 16 years admitted hospital for more 48 hours or who sustained traumatic death. Pediatric defined as not being directly transported PTC when one available within 30...