A5039754793- Cell Adhesion Molecules Research
- Sarcoma Diagnosis and Treatment
- Systemic Lupus Erythematosus Research
- Pancreatic and Hepatic Oncology Research
- MRI in cancer diagnosis
- Ocular Diseases and Behçet’s Syndrome
- Immunotherapy and Immune Responses
- Radiology practices and education
- Cardiovascular Disease and Adiposity
- Glaucoma and retinal disorders
- Cancer Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Blood Coagulation and Thrombosis Mechanisms
- Ocular Oncology and Treatments
- Mathematical Biology Tumor Growth
- Lanthanide and Transition Metal Complexes
- Atherosclerosis and Cardiovascular Diseases
- Ovarian cancer diagnosis and treatment
- Corneal surgery and disorders
- Diversity and Career in Medicine
- Otitis Media and Relapsing Polychondritis
- Liver Disease Diagnosis and Treatment
- Pancreatitis Pathology and Treatment
- Radiation Dose and Imaging
- Testicular diseases and treatments
University of North Carolina at Chapel Hill
2022-2025
Old Dominion University
2024
Moffitt Cancer Center
2015-2023
Duke University
2023
Resonance Research (United States)
2023
University of Pennsylvania
2018
University of South Florida
2013-2017
Florida College
2017
AtlantiCare
2016
University of Alabama at Birmingham
2016
Abstract Immunotherapy efficacy is limited in melanoma, and combinations of immunotherapies with other modalities have yielded improvements but also adverse events requiring cessation treatment. In addition to ineffective patient stratification, impaired by paucity intratumoral immune cells (itICs); thus, effective strategies safely increase itICs are needed. We report that dietary administration l -fucose induces fucosylation cell surface enrichment the major histocompatibility complex...
Background Metastatic uveal melanoma (UM) carries a poor prognosis; liver is the most frequent and often solitary site of recurrence. Available systemic treatments have not improved outcomes. Melphalan percutaneous hepatic perfusion (M‐PHP) allows selective intrahepatic delivery high dose cytotoxic chemotherapy. Methods Retrospective analysis outcomes data UM patients receiving M‐PHP at two institutions was performed. Tumor response toxicity were evaluated using RECIST 1.1 Common Terminology...
Abstract Early-stage and metastatic breast cancers (MBC) can exhibit genomic heterogeneity, even within the same individual. Response to therapy in cancer patients with multiple metastases also be heterogeneous, different degrees of responsiveness drug(s) across sites, termed “mixed response,” patient. Whether this treatment response variability is influenced by factors such as intrinsic tumor characteristics lesions and/or microenvironment unknown. Through analysis from patient, assayed 6...
Objective The aim of this study was to determine if magnetic resonance imaging (MRI) performed with hepatobiliary phase results in higher lesion conspicuity and produces measurements interobserver agreement than other MRI sequences when neuroendocrine hepatic metastases. Methods Patients who had MRIs both gadoxetate disodium gadopentetate dimeglumine contrast within a 6-month span were identified, 23 lesions selected. Three radiologists 1 oncologist measured the greatest diameter each on...
Abstract Background Quantification of skeletal muscle using computed tomography (CT) is accessible cancer patients' standard oncologic images. Reduced mass may be related to reduced respiratory strength; however, the impact this on lung functional parameters not characterized in adult allogeneic haematopoietic stem cell transplant (alloHCT) recipients. Methods A consecutive retrospective series ( n = 296) patients who had alloHCT at a comprehensive centre between March 2005 and April 2015...
Regional therapy for metastatic melanoma to the liver represents an alternative systemic therapy. Hepatic progression-free survival (HPFS), (PFS), and overall (OS) were evaluated.A retrospective review of patients with metastases from cutaneous or uveal treated yttrium-90 (Y90), chemoembolization (CE), percutaneous hepatic perfusion (PHP) was conducted.Thirty (6 Y90, 10 PHP, 12 CE, 1 PHP then CE PHP) included. Multivariate analysis showed improved HPFS versus Y90 (P=0.004), (P=0.02) but not...
Chemotherapy remains a primary treatment for metastatic cancer, with tumor response being the benchmark outcome marker. However, therapeutic in cancer is unpredictable due to heterogeneity drug delivery from systemic circulation solid tumors. In this proof-of-concept study, we evaluated chemotherapy concentration at tumor-site and its association therapy by applying mathematical model. By using pre-treatment imaging, clinical biologic variables, regimen inform model, estimated patients...
Leukocyte adhesion to the vascular wall is a critical early step in pathogenesis of inflammatory diseases and mediated part by leukocyte integrin, VLA-4, which binds endothelial cell molecule (VCAM) -1. Here, we investigate VLA-4's role endotoxin-induced uveitis (EIU). At various time points (6-48 h) after EIU induction, severity inflammation was evaluated quantifying protein content aqueous fluid, firm retinal vessels, number extravasated leukocytes into vitreous. Functional activation...
Sarcomas are connective tissue tumors accounting for only 1% of all adult malignancies. Leiomyosarcoma (LMS) is a sarcoma arising from smooth muscle cells, and accounts 10-20% sarcomas. A subtype LMS those originating the blood vessels. inferior vena cava sarcomatous tumor, with less than 350 cases described in literature. It carries poor prognosis, 5- 10-year survival rates 31.4% 7.4%, respectively. We present case 46-year-old female no significant past medical history presented to...
A laryngopharyngeal rhabdomyoma was diagnosed in a four-year-old dog with clinical signs of upper respiratory obstruction. In people, rhabdomyomas have predilection for the head and neck area. Features this tumor were compared an oncocytoma which it may be confused.
To evaluate the gender and racial diversity of plenary session speakers in annual meetings Society Abdominal Radiology (SAR) over 2016 to 2020.The brochures SAR were reviewed for titles. Publicly available institutional profiles social media by investigator order infer race. Gender assessments men, women, transgender women or non-binary. Race was classified as White, Black African American, American Indians Alaskan Natives, Asian, Native Hawaiian Pacific Islander Multiracial. Statistical...
Penile cancer is an uncommon primary genitourinary malignancy, the vast majority representing superficial squamous cell carcinomas. However, less common skin cancers, secondary malignancies, mesenchymal neoplasms, and hematopoietic tumors do affect penis. Medical history, atypical presentation, deep epicenter of a penile mass may raise question nonepithelial neoplasm. We describe discuss 2 examples rare deep-seated leiomyosarcoma B-cell lymphoma.
4574 Background: CG0070 is a replication-competent oncolytic adenovirus engineered to target RB deficient tumor cells and express GM-CSF. has previously demonstrated safety efficacy against BCG-exposed high risk non-muscle invasive bladder cancer through lysis anti-tumor immune activation. We tested the of in combination with N as neoadjuvant therapy for MIBC C-ineligible patients this study (NCT04610671). Methods: pts (cT2-4a, N≤1) were enrolled. Pts received 6 weekly intravesical (1x10 12...
Abstract Background Early-stage and metastatic breast cancer (MBC) exhibit genomic heterogeneity, with inter-patient variability between primary tumors, intra-patient of tumors versus metastasis, even different sites within the same patient. Response to therapy in MBC can also be heterogeneous, termed "mixed response", degrees responsiveness drug(s) across Whether this treatment response is influenced by factors such as intrinsic characteristics lesions and/or microenvironment unknown....