A5037909389- Gestational Diabetes Research and Management
- Gastrointestinal motility and disorders
- Diet and metabolism studies
- Adipose Tissue and Metabolism
- Birth, Development, and Health
- Pregnancy and preeclampsia studies
- Therapeutic Uses of Natural Elements
- Reproductive tract infections research
- Cancer Risks and Factors
- Complementary and Alternative Medicine Studies
- Adipokines, Inflammation, and Metabolic Diseases
- Herbal Medicine Research Studies
- Sexual function and dysfunction studies
- Magnesium in Health and Disease
- Metabolism and Genetic Disorders
- Genetic Neurodegenerative Diseases
- Metabolomics and Mass Spectrometry Studies
- Digestive system and related health
- Atherosclerosis and Cardiovascular Diseases
- Fatty Acid Research and Health
- Cancer Genomics and Diagnostics
- Cancer, Lipids, and Metabolism
- Natural Products and Biological Research
- Cardiovascular Issues in Pregnancy
- Breast Cancer Treatment Studies
National Institute of Genomic Medicine
2018-2025
Instituto de Medicina Genómica
2021
Background: Magnesium is a mineral that modulates several physiological processes. However, its relationship with intestinal microbiota has been scarcely studied. Therefore, this study aimed to assess the role of dietary magnesium content modulate Wistar male rats. Methods: Rats were randomly assigned one three diets: control diet (C-Mg; 1000 mg/kg), low (L-Mg; 60 and high (H-Mg; 6000 for two weeks. After treatment, fecal samples collected. Microbiota composition was assessed by sequencing...
Abstract Background Gestational diabetes mellitus (GDM) represents the main metabolic alteration during pregnancy. The available methods for diagnosing GDM identify women when disease is established, and pancreatic beta-cell insufficiency has occurred.The present study aimed to generate an early prediction model (under 18 weeks of gestation) those who will later be diagnosed with GDM. Methods A cohort 75 pregnant was followed gestation, which 62 underwent normal term pregnancy 13 were...
Infertility, both primary and secondary, is strongly influenced by microbiological factors, with the vaginal microbiota playing a key role in reproductive health. The aim of this study was to characterize 136 Mexican women diagnosed infertility-primary (n = 58) secondary 78)-by evaluating presence pathogenic bacterial species their associations infertility conditions. Samples were obtained through cervical swabs, microorganism identification performed using qPCR techniques. Analysis revealed...
Differential abundance analysis of ASVs between R and NR were identified, potentially implicated in dietary responsiveness. Bacterial biomarkers are useful to classify IBS individuals by responsiveness low FODMAP diet.
Background: M1 macrophages involved in pro-inflammatory processes can be induced by low-density lipoproteins (LDL), giving rise to foam cells. In the atheroma plaque, it has been identified that males present more advanced lesions associated with infiltration. Therefore, our study aims investigate sex-related changes transcriptome of during internalization process LDL particles. Methods: Peripheral blood mononuclear cells (PBMCs) from healthy male and female subjects were separated using...
Spinocerebellar ataxia type 7 (SCA7), a neurodegenerative disease characterized by cerebellar and retinal degeneration, is caused an abnormal CAG repeat expansion in the ATXN7 gene coding region. The onset severity of SCA7 are highly variable between patients, thus identification sensitive biomarkers that accurately diagnose monitoring its progression needed. With aim identified SCA7-specific metabolites with clinical relevance, we report for first time, to best our knowledge, metabolomics...
Abstract Context Pancreatic β-cell function impairment is a key mechanism for developing gestational diabetes mellitus (GDM). Maternal and placental exosomes regulate maternal responses during hyperglycemia. Studies have associated exosomal micro-RNAs (miRNAs) with GDM development. To date, no studies been reported that evaluate the profile of miRNAs present in early stages gestation from pregnancies develop GDM. Objective We assessed whether early-pregnancy serum placenta-derived miRNA...
During normal pregnancy, metabolic changes occur causing weight gain and insulin resistance to provide the fetus with substrates for growth development. Hence, a plasticity must exist allow mother adapt correctly upon pregnancy overload, preventing adverse outcomes like gestational diabetes. The aim of study was analyze during in women pregestational BMI. Glucose, triglycerides total cholesterol were determined, indirect calorimetry performed fasting after consumption high‐carbohydrate meal....
Background: At present, the interpretation of any dysfunction by pathogenic microbial colonization digestive tract can be considered as rupture microbiotic balance in injured or infected area. Phytodrugs with useful properties to intestinal microbiota equibiotics represent an alternative recently proposed Medicinal Plant Research Company Phytomedicamenta S.A. The Equibiotic-GI® is a phytodrug developed combination two plant extracts, obtained from leaves Psidium guajava L, (Myrtaceae) and...
Gestational diabetes (GD) represents the main metabolic alteration during pregnancy affecting 17% of pregnancies in Mexico. The clinical relevance this pathology is short and long-term complications such as obesity, diabetes, hypertension; that affect mother child. GD often diagnosed between weeks 24 to 28 gestation through an oral glucose tolerance test. aim present study was identify early metabolites (under 18 gestation) on women who were with GD; order, generate prediction model those...
e12652 Background: YWBC is associated with aggressive biology a higher mortality rate and recurrence risk. Similar to older patients, pCR after NAC surrogate marker of disease-free survival overall in YWBC. However, who did not achieve significantly worse. Metabolic profile (MP) has been used for biomarker discovery monitor chemotherapy response. Few studies focus on using metabolomics predict BC. The study aimed identify MP YWBC, before response chemotherapy. Methods: A targeted approach...