A5077537309- Reproductive tract infections research
- HIV/AIDS Research and Interventions
- HIV Research and Treatment
- Hepatitis B Virus Studies
- Tuberculosis Research and Epidemiology
- Hepatitis C virus research
- Mycobacterium research and diagnosis
- Cervical Cancer and HPV Research
- Systemic Lupus Erythematosus Research
- Liver Disease Diagnosis and Treatment
- Herpesvirus Infections and Treatments
- HIV/AIDS drug development and treatment
- Reproductive Health and Contraception
- Sex work and related issues
- Viral gastroenteritis research and epidemiology
- Animal Virus Infections Studies
- Antibiotic Resistance in Bacteria
- Bacterial biofilms and quorum sensing
- Pharmaceutical and Antibiotic Environmental Impacts
- Syphilis Diagnosis and Treatment
- Cancer therapeutics and mechanisms
- Actinomycetales infections and treatment
- Antimicrobial Resistance in Staphylococcus
- Infectious Diseases and Mycology
- Geological and Geochemical Analysis
University of Pavia
2001-2017
Policlinico San Matteo Fondazione
1996-2010
Istituti di Ricovero e Cura a Carattere Scientifico
1996-2010
To evaluate the water compartment antibiotic-resistance contamination rates, 11 wells, five streams, and four treatment plants located in Oltrepò Pavese area were screened for presence of third generation cephalosporins resistant Gram-negative bacteria. Enterobacteriaceae also characterized Extended-Spectrum-β-Lactamases (ESBLs), carbapenemases, mcr-1 genes presence. From December 2014 to November 2015, 246 samples filtered, plated on Plate Count Agar, MacConkey Agar with cefotaxime....
The Mycobacterium tuberculosis mmpL7 gene, encoding a hypothetical resistance nodulation division transporter, confers high level to isoniazid when overexpressed in smegmatis. decreased the presence of efflux pump inhibitors reserpine and CCCP (carbonyl cyanide m-chlorophenylhydrazone). Energy-dependent from M. smegmatis cells expressing gene was observed.
The new antitubercular drug candidate 2-[2-S-methyl-1,4-dioxa-8-azaspiro[4.5]dec-8-yl]-8-nitro-6-(trifluoromethyl)-4H-1,3-benzothiazin-4-one (BTZ043) targets the DprE1 (Rv3790) subunit of enzyme decaprenylphosphoryl-beta-d-ribose 2'-epimerase. To monitor potential development benzothiazinone (BTZ) resistance, a total 240 sensitive and multidrug-resistant Mycobacterium tuberculosis clinical isolates from four European hospitals were surveyed for presence mutations in dprE1 gene BTZ...
OBJECTIVE: Lingual orthodontics is becoming more popular in dental practice. The purpose of the present investigation was to compare plaque formation on teeth bonded with same bracket onto buccal or lingual surface, non-bonded control teeth, via an vivo growth experiment over a 30-day period. MATERIAL AND METHODS: A randomized controlled trial split-mouth design set up enrolling 20 students. Within each subject sites and brackets were followed. Clinical periodontal parameters (periodontal...
ABSTRACT The dynamics of the genetic diversification hepatitis C virus (HCV) populations was addressed in perinatal infection. Clonal sequences hypervariable region 1 putative E2 envelope protein HCV were obtained from four HCV-infected newborns (sequential samples spanning a period 6 to 13 months after birth) and their mothers (all collected at delivery). data show that variants detected between birth third month life present delivery. In newborns, unique viral variant (or small group...
<b>Objectives:</b> To link local proinflammatory cytokines with HIV related nucleic acids in cervico-vaginal secretions and the factors associated them. <b>Methods:</b> An observational study on 60 positive women attending department of obstetrics gynaecology, University Pavia, Italy. HIV-1 RNA plasma, proviral HIV-1-DNA, cell free were evaluated by competitive polymerase chain reaction (c-PCR) reverse transcriptase PCR (cRT-PCR). IL-1β, IL-6, TNF-α measured ELISA lavages. Multiple...
To assess HIV-related nucleic acids in cervico-vaginal secretions and the factors associated with them.Observational study.Department of Obstetrics Gynaecology, University Pavia, Italy.HIV-positive patients attending a cytology service.Paired blood lavage samples were obtained from 122 known HIV-seropositive during periodic visits for cytologic screening lower genital tract neoplasia. Vaginal specimens diagnosis bacterial vaginosis, trichomonas vaginalis candida infection also obtained....
In Brief OBJECTIVE: Although human immunodeficiency virus (HIV) infection is a well-known risk factor for cervical intraepithelial neoplasia (CIN), the influence of CIN on cervicovaginal shedding HIV poorly understood. The purpose this study was to evaluate association between and in secretions. METHODS: Two hundred sixteen HIV-seropositive patients were followed up by Pap test, colposcopy, targeted biopsies median 16 months (range 0–94). A diagnosis low-grade made basis test either...
Objective: The purpose of this study was to evaluate the presence HIV-1 in cervico-vaginal secretions pregnant as compared non-pregnant HIV-seropositive women. Patients and Methods: We 43 known HIV seropositive patients versus 241 age-matched (± 2 years) control subjects. In blood samples were obtained during each trimester pregnancy. subjects same at enrolment. RNA measured plasma; proviral DNA, cell-associated cell-free secretion by competitive polymerase chain reaction (cRT-PCR) reverse...
To assess the prognostic role of proviral DNA in peripheral blood mononuclear cells (PBMC) patients with undetectable viremia over long-term highly active antiretroviral therapy (HAART).Eighty-two human immunodeficiency virus (HIV)-1-infected patients, free acquired syndrome (AIDS), received zidovudine plus lamivudine indinavir. Levels plasma HIV-RNA, and PBMC RNA unspliced (US) transcripts were evaluated by using competitive polymerase chain reaction (cPCR) assays, every 3 months 1...
In Brief Objective To evaluate simultaneous human immunodeficiency virus (HIV)-related nucleic acids and papillomavirus (HPV)-DNA in cervicovaginal secretions of HIV-seropositive women. Methods We collected 47 paired blood lavage samples from 124 known HIV-1–seropositive Proviral HIV-1 DNA, cell-associated, cell-free RNA were quantitatively evaluated by competitive polymerase chain reaction (PCR) reverse transcription PCR. Polymerase subsequent restriction fragment length polymorphism...
To evaluate a) the safety and immunogenicity of anti-HAV-inactivated vaccine administered during first year life to anti-HAV seronegative babies, b) antibody persistence in a low/intermediate endemic area.After having obtained informed written consent from mothers, 92 babies were vaccinated at 4 10 mo age. All birth did not present HAV-RNA shedding three serial stool samples taken 1, 2 3 age.No general side effects (fever > 38 degrees C) observed. After dose vaccine, 70/82 (85.4%) developed...