A5016858526- Parvovirus B19 Infection Studies
- Cytomegalovirus and herpesvirus research
- Herpesvirus Infections and Treatments
- Monoclonal and Polyclonal Antibodies Research
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Polyomavirus and related diseases
- Multiple Myeloma Research and Treatments
- Pharmaceutical and Antibiotic Environmental Impacts
- Cancer Immunotherapy and Biomarkers
- Acute Myeloid Leukemia Research
- Clinical Nutrition and Gastroenterology
- Medical Imaging and Pathology Studies
- Virus-based gene therapy research
- Immune Cell Function and Interaction
- Histiocytic Disorders and Treatments
- Antibiotic Resistance in Bacteria
- CAR-T cell therapy research
- Organ Transplantation Techniques and Outcomes
- Immunotherapy and Immune Responses
- Hepatitis C virus research
- Bacterial biofilms and quorum sensing
- Full-Duplex Wireless Communications
- Viral-associated cancers and disorders
- Childhood Cancer Survivors' Quality of Life
- Nutrition and Health in Aging
Policlinico San Matteo Fondazione
2021-2024
Istituti di Ricovero e Cura a Carattere Scientifico
2021-2024
University of Pavia
2017
To evaluate the water compartment antibiotic-resistance contamination rates, 11 wells, five streams, and four treatment plants located in Oltrepò Pavese area were screened for presence of third generation cephalosporins resistant Gram-negative bacteria. Enterobacteriaceae also characterized Extended-Spectrum-β-Lactamases (ESBLs), carbapenemases, mcr-1 genes presence. From December 2014 to November 2015, 246 samples filtered, plated on Plate Count Agar, MacConkey Agar with cefotaxime....
Despite advances in their diagnosis and treatment, pediatric cancers remain among the leading causes of death childhood. The development immunotherapies other forms targeted therapies has significantly changed prognosis some previously incurable adult population. However, so far, results cohorts are disappointing, which is mainly due to differences tumor biology, including extreme heterogeneity a generally low mutational burden. A central role limited efficacy immunotherapeutic approaches...
Abstract Background Human cytomegalovirus (HCMV) is the leading infectious cause of congenital disabilities. We designed a prospective study to investigate rate, outcome, and risk factors CMV (cCMV) infection in neonates born immune women, potential need effectiveness hygiene recommendations this population. Methods The was composed 2 sequential parts: an epidemiology (part 1) prevention 2) study. Performance part depended upon cCMV rate >0.4%. Women enrolled 1 did not receive...
Background: Strain-specific antibodies to human cytomegalovirus (HCMV) glycoproteins B and H (gB gH) have been proposed as a potential diagnostic tool for identifying reinfection. We investigated genotype-specific IgG antibody responses in parallel with defining the gB gH genotypes of infecting viral strains. Methods: Subjects primary (n = 20) or non-primary 25) HCMV infection were studied. The seven (gB1-7) two (gH1-2) determined by real-time PCR whole genome sequencing, measured...
Background Refractory or metastatic nasopharyngeal carcinoma (NPC) patients have a poor prognosis due to the lack of effective salvage treatments and prolonged survival by means combination chemotherapy being described only for minority younger with oligometastatic disease. Targeting Epstein - Barr virus (EBV) proteins expressed in NPC cells has been shown be feasible strategy that could help control systemic Patients Methods Between 2011 2014, 16 recurrent/metastatic EBV-NPC received...
Polyomavirus BK (BKPyV)-associated nephropathy (BKPyV-nephropathy) remains a significant cause of premature kidney allograft failure. In the absence effective antiviral treatments, current therapeutic approaches rely on immunosuppression (IS) reduction, possibly at risk inducing alloimmunity. Therefore, we sought to explore long-term effects tailored viro-immunologic surveillance and treatment program for BKPyV development alloimmunity graft outcome. Forty-five pediatric transplant...
Acute myeloid leukemia (AML) with nucleophosmin (NPM1) genetic mutations is the most common subtype in adult patients. Refractory or relapsed disease unfit patients after allogeneic hematopoietic stem cell transplantation (allo-HSCT) has a poor prognosis. NPM1-mutated protein, stably expressed on tumor cells but not normal tissues, may serve as an ideal target for AML immunotherapy. The study aim was to investigate feasibility of producing mutated-NPM1-specific cytotoxic T (CTLs) suitable...