A5047763903- Antibiotic Resistance in Bacteria
- Pharmaceutical and Antibiotic Environmental Impacts
- Bacterial biofilms and quorum sensing
- Antibiotics Pharmacokinetics and Efficacy
- Infections and bacterial resistance
- Enterobacteriaceae and Cronobacter Research
- Vibrio bacteria research studies
- Antibiotic Use and Resistance
- Mycobacterium research and diagnosis
- Bacterial Identification and Susceptibility Testing
- Urinary Tract Infections Management
- Medical Device Sterilization and Disinfection
- Management, Economics, and Public Policy
- Plant Pathogenic Bacteria Studies
- Diverse academic and cultural studies
- Antimicrobial Resistance in Staphylococcus
- Listeria monocytogenes in Food Safety
- Antifungal resistance and susceptibility
- Nosocomial Infections in ICU
- Polyomavirus and related diseases
- Inhalation and Respiratory Drug Delivery
- Edible Oils Quality and Analysis
- Animal Ecology and Behavior Studies
- Full-Duplex Wireless Communications
- Urban Planning and Valuation
University of Pavia
2010-2020
United States Nuclear Regulatory Commission
2012
To evaluate the water compartment antibiotic-resistance contamination rates, 11 wells, five streams, and four treatment plants located in Oltrepò Pavese area were screened for presence of third generation cephalosporins resistant Gram-negative bacteria. Enterobacteriaceae also characterized Extended-Spectrum-β-Lactamases (ESBLs), carbapenemases, mcr-1 genes presence. From December 2014 to November 2015, 246 samples filtered, plated on Plate Count Agar, MacConkey Agar with cefotaxime....
ABSTRACT Forty-four nonreplicate clinical isolates of Pseudomonas aeruginosa that were resistant to extended-spectrum cephalosporins (ceftazidime and cefepime) aztreonam, putatively produced an acquired extended- spectrum β-lactamase (ESBL), according the results a double-disk synergy test, had been involved in nosocomial outbreaks obtained from six different hospitals northern Italy screened for presence bla PER ESBL determinants. Twenty isolates, associated with nine independent occurred...
Abstract Background Acinetobacter baumannii is emerging as an important nosocomial pathogen. Multidrug resistance, well ability to withstand environmental stresses, makes eradication of A. difficult, particularly from hospital settings. Results Over a six-year period, 73 isolates were collected infected patients in two hospitals Italy. While 69 out the displayed identical multidrug antibiotic resistance pattern, they susceptible carbapenems. Genetic profiles these isolates, determined by...
Extended-spectrum beta-lactamases (ESBLs), AmpC-type (ACBLs) and carbapenemases are among the most important resistance mechanisms in Enterobacteriaceae . This study investigated presence of these consecutive non-replicate isolates Escherichia coli (n = 2,352), Klebsiella pneumoniae 697), Proteus mirabilis 275) from an Italian nationwide cross-sectional survey carried out October 2013. Overall, 15.3% were non-susceptible to extended-spectrum cephalosporins but susceptible carbapenems...
Carbapenem-resistant Acinetobacter baumannii (CRAb) is emerging worldwide as a public health problem in various settings. The aim of this study was to investigate the prevalence CRAb isolates Italy and characterize their resistance mechanisms genetic relatedness. A countrywide cross-sectional survey carried out at 25 centers mid-2011. were reported from all participating centers, with overall proportions 45.7% 22.2% among consecutive nonreplicate clinical A. inpatients (n = 508) outpatients...
ABSTRACT An outbreak of Pseudomonas aeruginosa showing a multidrug-resistant (MDR) phenotype (including carbapenems, ceftazidime, cefepime, gentamicin, tobramycin, and fluoroquinolones) was observed, during 5-month period, in general intensive care unit large tertiary clinical research hospital southern Italy. The involved 15 patients, with total 87 isolates, mostly from lower respiratory tract specimens. Analysis isolates the revealed production metallo-β-lactamase (MBL) activity,...
ABSTRACT We report multifocal detection (four different cities in northern Italy) of Proteus mirabilis isolates resistant to both oxyimino- and 7-α-methoxy-cephalosporins producing a novel acquired AmpC-like β-lactamase. The enzyme, named CMY-16, is variant the CMY/LAT lineage, which differs from closest homologues, CMY-4 CMY-12, by single amino acid substitution (A171S or N363S, respectively) CMY-2 two substitutions W221R). Expression cloned bla CMY-16 gene Escherichia coli decreased...
Abstract Background Rationale and aims of the study were to compare colonization frequencies with MDR bacteria isolated from LTCF residents in three different Northern Italian regions, investigate risk factors for genotypic characteristics isolates. The screening included Enterobacteriaceae expressing extended-spectrum β-lactamases (ESβLs) high-level AmpC cephalosporinases, carbapenemase-producing , Pseudomonas aeruginosa or Acinetobacter baumannii methicillin-resistant Staphylococcus aureus...
Long Term Care Facilities (LTCFs) play a key role in guaranteeing care to patients developed countries. Many patients, mostly elderly, access LTCFs at some time their lives, and healthcare pathways often require them move back forth between hospital outpatient settings. These patterns bring about new challenges regarding infection control, especially associated infections.A point prevalence study was conducted 23 Italian LTCFs, identify colonization with urinary catheter (>24 hours). Species...
Acinetobacter baumannii is a Gram-negative organism reported worldwide as cause of health-care-associated infections, particularly in intensive care units (ICUs). The aim this study to describe the emergence and spread carbapenem-resistant A. (CRAB) isolates hospitalized patients. From March November 2009, multidrug-resistant CRAB were obtained from 21 patients different wards (mostly ICUs). Antimicrobial susceptibility was determined by using Etest method. Carbapenem aminoglycoside...
Background: The spread of carbapenemase genes, such as blaNDM-1, in Proteus mirabilis poses a public health threat. aim the study was to characterize genome and plasmids sequences an NDM-1-positive strain (IBCRE14), which isolated 2019 from catheterized patient hospitalized Italy. Methods: Whole sequencing (WGS) IBCRE14 performed on extracted genomic DNA using Sequel I platform. Genome assembly "Microbial Assembly". Genomic analysis conducted by uploading contigs ResFinder PlasmidFinder...
Polyomaviruses KI (KIPyV) and WU (WUPyV) were described recently in children with acute respiratory disease. The pathogenic potential of these human viruses has not been determined completely, but a correlation between immunosuppression virus reactivation suggested. In the present study, association KI/WUPyV infection was investigated using sequential nasopharyngeal aspirates from asymptomatic adult hematopoietic stem cell transplant recipients. parallel, an investigation on WU/KIPyV...
Aim of this study was to genetically characterize two carbapenemase-producing Escherichia coli strains obtained from a pediatric patient affected by diarrhea, expressing OXA-181 and/or NDM-5 type enzymes. The above microorganisms were collected in the same Desenzano hospital (Northern Italy) where blaNDM-5 gene detected for first time Italy 3 years ago. One strain (5P), belonged sequence ST405/ST477 (according Pasture/Oxford schemes) and serotype O102:H6. It characterized 130562 bp...
Antimicrobial consumption in veterinary medicine has led to the spread of multi drug-resistance clinically important bacteria, with companion animals and their environment involved as emerging reservoirs. While CTX-M-15 CMY-2 acquired β-lactamases have been widely detected bacterial population breeding European area, DHA-1 enzymes rarely reported medicine. The aim study was characterize Escherichia coli associated mortality a litter Bulldog puppies kennel located Pesaro Central Italy. E....
We report two KPC-producing Citrobacter freundii isolates from unrelated patients. In one case, bla KPC-2 was harbored on a novel variant of Tn 4401 transposon an IncN plasmid conjugated together with coresident IncA plasmid, whereas in the other one, KPC-3 4401a located IncX3-IncA self-conjugative fusion.
Acinetobacter baumannii is a known opportunistic pathogen, dangerous for public health mostly due to its ability rapidly acquire antibiotic-resistance traits. Its genome was described as characterized by remarkable plasticity, with high frequency of homologous recombinations and proliferation Insertion Sequences (IS). The SMAL pulsotype an A. strain currently isolated only in Italy, low incidence persistence over the years. In this present work, we have conducted comparative genomic analysis...