A5101945869- Tuberculosis Research and Epidemiology
- Diagnosis and treatment of tuberculosis
- Infectious Diseases and Tuberculosis
- Antimicrobial Resistance in Staphylococcus
- Antibiotic Resistance in Bacteria
- Protein purification and stability
- Hepatitis C virus research
- Analytical Chemistry and Chromatography
- Cancer Cells and Metastasis
- Biosimilars and Bioanalytical Methods
- Liver Disease Diagnosis and Treatment
- Orthopedic Infections and Treatments
- Lipid metabolism and disorders
- Clostridium difficile and Clostridium perfringens research
- Viral-associated cancers and disorders
- Metastasis and carcinoma case studies
- Burn Injury Management and Outcomes
- Electrolyte and hormonal disorders
- Cancer, Stress, Anesthesia, and Immune Response
- Microbial Metabolism and Applications
- Bacterial biofilms and quorum sensing
- Prostate Cancer Treatment and Research
- Renal Transplantation Outcomes and Treatments
- Mesenchymal stem cell research
- Acute Lymphoblastic Leukemia research
University of South China
2024
National Institute for Communicable Disease Control and Prevention
2024
National Institute of Allergy and Infectious Diseases
2020-2021
National Institutes of Health
2020-2021
Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital
2021
Nanjing Medical University
2021
Jiangsu Province Hospital
2021
Nanjing University of Chinese Medicine
2019
Yuhuangding Hospital
2019
Qingdao University
2019
FDG-PET/CT imaging correlates with long-term outcomes during early bactericidal activity testing of tuberculosis drugs in patients.
Direct bronchial spread of tuberculosis was extensively described in pre-antibiotic human pathology literature but this description has been overlooked the post-antibiotic era, which most data come from animal models that emphasise granuloma. Modern techniques, such as [
We describe novel rifamycin derivatives (new chemical entities [NCEs]) that retain significant activity against a comprehensive collection of Staphylococcus aureus strains are resistant to rifamycins. This contains 21 the 26 known single-amino-acid alterations in RpoB, target Some NCEs also demonstrated lower frequency resistance development than rifampin and rifalazil S. as measured emergence test. When assayed for strongest rifamycin-resistant mutants, several had MICs 2 microg/ml,...
Staphylococcus aureus is a globally disseminated drug-resistant bacterial species. It remains leading cause of hospital-acquired infection, primarily among immunocompromised patients. In 2012, the Affiliated People’s Hospital Jiangsu University experienced putative outbreak methicillin-resistant S. (MRSA) that affected 12 patients in Neurosurgery Department. this study, whole-genome sequencing (WGS) was used to gain insight into epidemiology caused by MRSA, and traditional genotyping...
The present study aims to characterize the effect of chronic intermittent hypoxia and HIF1α on non-alcoholic steatohepatitis (NASH) process in mice, explore role Treg/Th17 balance formation NASH inflammation fibrosis. To achieve this purpose, simple steatosis was induced mice by high-fat diet administration. Subsequently, simulated intraperitoneally injecting sodium nitrite. changes inflammation, fibrosis, liver were quantified under condition after tail vein injection HIF1α-siRNA. In...
Surgical resection is often the preferred treatment for non-small cell lung cancer (NSCLC) patients. Predictive biomarkers after surgery can help monitoring and treating patients promptly, so as to improve clinical outcome. In this study, we evaluated one potential candidate biomarker, folate receptor-positive circulating tumor (FR+CTC), by investigating its prognostic predictive significance in NSCLC who underwent surgery. prospective, observational enrolled were eligible receive Prior...
Objectives To investigate the clinical epidemiological and drug resistance (DR) characteristics of lymph node tuberculosis (LNTB) in Hunan Province which locates South-central China, to provide scientific clues for effective prevention treatment LNTB. Methods We retrospectively collected LNTB patients with Mycobacterium culture positive at Chest Hospital, biggest TB reference hospital from January 2013 December 2021. The multiple demographic, susceptibility data were hospital’s electronic...
This study aimed to investigate the epidemiological and drug resistance (DR) characteristics of extrapulmonary tuberculosis (EPTB) in South-Central China.
Abstract Six months of chemotherapy using current agents is standard care for pulmonary, drug-sensitive tuberculosis (TB), even though some are believed to be cured more rapidly and others require longer therapy. Understanding what factors determine the length treatment required durable cure in individual patients would allow individualization durations, provide better clinical tools appropriate duration new regimens, as well reduce cost large Phase III studies optimal combinations use TB...
The research analyzed a group of patients to develop statistical nomogram and web-based survival rate predictor for the comprehensive estimate overall (OS) children with acute myeloid leukemia.Between 1999 2015, we used Therapeutically Applicable Research Generate Effective Treatments (TARGET) database evaluate randomly divide 440 diagnosed AML into population training (n = 309) validation 131). analysis Lasso Cox was identify separate predictive variables. We have essential forecasting...
Researches on bone marrow mesenchymal stem cells (BMMSCs) have generated controversial results in tumor research. In the present study, we aimed to explore functions of BMMSCs gastric cancer and possible mechanism a mimicking microenvironment stomach.Transwell co-cultured system was used co-culture SGC-7901 cells. some experiments, androgen its antagonist were added into as required. Cell viability, cell apoptosis, mRNA protein expressions apoptosis- JNK signaling- associated genes...
Objective To systematically evaluate the optimal dose of early enteral nutrition support in critically ill patients. Methods Systematic search database including PubMed, Web science, Scopus, CINAHL, CBM, CNKI. RCTs about selections patients were chosen according to include and exclude criteria by two researchers independently. Cochrane system evaluation manual bias risk assessment was used quality literature. RevMan5.3 Meta analysis software analyze data. Results A total 1 571...
Osteoarticular tuberculosis (OATB) is one of the most common forms extrapulmonary tuberculosis; however, limited epidemiological data are available on this public health concern worldwide, especially in developing countries. This study aimed to analyze clinical epidemiology and drug resistance characteristics OATB cases Hunan province which located South-central China.
Reliable and robust human dose prediction plays a pivotal role in compound optimization advancement drug discovery. The of discovery requires proper modelling preclinical intravenous (IV) pharmacokinetic (PK) data which is usually achieved either through non-compartmental analysis (NCA) or compartmental analysis. While NCA straightforward, it loses valuable information about the shape PK curves. In contrast, offers more comprehensive interpretation but poses challenges scaling up for...
Reliable and robust human dose prediction plays a pivotal role in compound optimization advancement drug discovery. The of discovery requires proper modelling preclinical intravenous (IV) pharmacokinetic (PK) data which is usually achieved either through non-compartmental analysis (NCA) or compartmental analysis. While NCA straightforward, it loses valuable information about the shape PK curves. In contrast, offers more comprehensive interpretation but poses challenges scaling up for...
To develop and validate a prognostic nomogram in eastern patients with hepatitis B virus (HBV)-associated hepatocellular carcinoma (HCC) portal vein tumor thrombus (PVTT) receiving trans-arterial chemoembolization drug-eluting beads (DEB-TACE).This retrospective study included 200 training cohort (n = 118) from institution 1 test 82) 2. All these received first-line DEB-TACE between October 2016 2018. Multivariate Cox proportional hazard regression analysis was performed on the to reveal...
Objective To evaluate the effects of ketamine anesthesia on proteome in hippocampus aged rats. Methods Thirty healthy male Wistar rats, 20 months, weighing 560-610 g, were divided into 2 groups (n=15 each) using a random number table method: control group (group C) and K). In K, 80 mg/kg was intraperitoneally injected, additional 1/2 initial dose given when righting reflex recovered, maintained for 3 h. Morris water maze test performed starting from 1st day after end anesthesia.Five...
Results: No serious side effects or complications were found.ALB of patients in group A significantly superior to B at 3 24 weeks.TBIL and PT markedly 4 12 weeks.MELD scores was 36 weeks.Improvements also found the manifestations ultrasound.Conclusion: Autologous MMSCs transplantation is safe effective for chronic hepatitis with liver failure.
Abstract BACKGROUND and AIMS Immunosuppressive therapy for IMN remains a controversial topic. In light of this, we performed network meta-analysis to compare the efficacy safety different pharmacological treatments idiopathic membranous nephropathy. METHODS: Twenty-eight randomized clinical trial (RCT) cases were included with 1759 instances nephropathy minimum 6-month follow-up. Treatment tacrolimus (TAC), cyclophosphamide (CTX), mycophenolate mofetil (MMF), chlorambucil, cyclosporin A...