A5101568439- SARS-CoV-2 and COVID-19 Research
- Electric Motor Design and Analysis
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Amyotrophic Lateral Sclerosis Research
- CRISPR and Genetic Engineering
- Birth, Development, and Health
- Calpain Protease Function and Regulation
- Viral gastroenteritis research and epidemiology
- Sensorless Control of Electric Motors
- Photosynthetic Processes and Mechanisms
- Advanced Surface Polishing Techniques
- Metal and Thin Film Mechanics
- Genomic variations and chromosomal abnormalities
- vaccines and immunoinformatics approaches
- Neurological Disease Mechanisms and Treatments
- Ion-surface interactions and analysis
- Glycosylation and Glycoproteins Research
- Monoclonal and Polyclonal Antibodies Research
- Animal Virus Infections Studies
- Inflammatory Biomarkers in Disease Prognosis
- Injection Molding Process and Properties
- Mesenchymal stem cell research
- Biochemical Acid Research Studies
- Microbial metabolism and enzyme function
- Ziziphus Jujuba Studies and Applications
Southwest Medical University
2022-2025
China Pharmaceutical University
2018-2025
State Key Laboratory of Natural Medicine
2018-2025
Sun Yat-sen University
2025
Affiliated Hospital of Southwest Medical University
2025
Shanghai University
2025
First Affiliated Hospital of Sichuan Medical University
2025
Guangzhou University of Chinese Medicine
2024
National Center for Nanoscience and Technology
2023-2024
University of Chinese Academy of Sciences
2024
Thrombocytosis had been found to be associated with tumor metastasis and poor prognosis in malignant tumors including colorectal cancer (CRC). In the present study, we investigated relationship between platelet biological features patients CRC China.The correlation of counts 150 cases their clinicopathological characteristics was explored. Furthermore, survival impact preoperative count also investigated.Statistically significant correlations lymph node distance (p=0.016 0.014), vascular...
Chlorinated polyfluoroalkyl ether sulfonate (F-53B), a substitute for perfluorooctane (PFOS), exerts stronger effect on neonatal thyroid hormone (TH) than PFOS. However, limited data its thyrotoxicity complicates early-life risk assessment. Here, Sprague-Dawley rats were gavaged with F-53B (0, 8, 80, 800 μg/kg/d) 63 days, from two weeks pre-pregnancy to post-weaning. The results showed accumulated in the juvenile rat thyroid, causing follicle colloid rupture and dysgenesis, marked by reduced...
Ischemic stroke (IS) is a globally life-threatening disease. Presently, few therapeutic medicines are available for treating IS, and rt-PA the only drug approved by US Food Drug Administration (FDA) in US. In fact, many agents showing excellent neuroprotection but no blood flow-improving activity animals have not achieved ideal clinical efficacy, while thrombolytic drugs improving flow without limited their wider application. To address these challenges meet huge unmet need, we designed...
Inhibitors of the protein kinase WEE1 have emerged as promising agents for cancer therapy. In this study, we uncover synergistic interactions between small-molecule inhibitors and defects in mRNA translation, mediated by activation integrated stress response (ISR) through GCN2. Using a pooled CRISPRi screen, identify GSPT1 ALKBH8 factors whose depletion confer hypersensitivity to inhibitor, AZD1775. We demonstrate that synergy depends on ISR activation, which is induced off-target activity...
Introduction Dysphagia is one of the common complications stroke. The use high-frequency (10 Hz) repetitive transcranial magnetic stimulation (rTMS) to stimulate suprahyoid motor cortex, which has been an evidence-based treatment method for dysphagia. Intermittent theta burst (iTBS) a newer type rTMS. There are few studies comparing iTBS with 10 Hz rTMS in post-stroke dysphagia (PSD). Therefore, our study describes rationale and design randomised controlled trial evaluate effects versus on...
Kirsten rat sarcoma viral oncogene homologue (KRAS) mutations are a common type of oncogenic mutation, widely observed in various cancers. The trafficking chaperone PDE6D (or PDEδ) has been proposed as an alternative target for KRAS, which led to the preclinical evaluation PDEδ inhibitors targeting KRAS mutant In this study, inspired by synergistic effect between and nicotinamide phosphoribosyl transferase (NAMPT), we report discovery first PDEδ/NAMPT dual inhibitors, may serve interesting...
"Unification of medicines and excipients" is the special principle which means fatty oil with pharmacodynamic activity derived from traditional Chinese medicine are taken as liquid lipids in perparation for dual-drug delivery, improve treatment effect reduce unnecessary excipients.The aim this study was to prepare a nanostructured lipid carrier (NLC) naringin (NG) containing coix seed (CSO) based on theory (NCNLC) order achieve synergistic antitumor against hepatocellular carcinoma.We...
Currently, there is no effective therapy for the treatment of highly metastatic triple-negative breast cancer (TNBC). Microvesicle (MV) formation crucial metastasis TNBC. Here we report a novel strategy to inhibit generation MVs intervention O2-3-Aminopropyl diazeniumdiolates 3a-f are designed and synthesized, which can be activated by lysyloxidase over-expressed in TNBC cells. The most active compound 3f able selectively release high levels NO cells, cell proliferation, reduce adhesion,...
It is unclear whether and how the CEO's financial background influences a firm's stock price crash risk. We take sample of China's listed firms to empirically explore this association. The study finds that has positive impact on Besides, we find mediating influence earnings management in nexus as CEOs with use their expertise engage real activity management. Further analysis reveals association between risk gets more pronounced non‐state enterprises CEO power.
Elevated levels of C-reactive protein (CRP) have been described as a prognostic factor in various types human malignancy. In the present study, potency CRP was validated for patients with colorectal cancer (CRC) order to guide patient management and define high-risk populations follow-up or therapeutic purposes. The association between high sensitivity-CRP (hs-CRP) total 123 CRC their clinicopathological characteristics explored. Subsequently, univariate multivariate analyses were performed...
Poststroke depression (PSD) is one of the most common psychiatric diseases afflicting stroke survivors, yet underlying mechanism poorly understood. The pathophysiology PSD presumably multifactorial, involving ischemia-induced disturbance in context psychosocial distress. homeostasis glucose metabolism crucial to neural activity. In this study, we showed that consumption was decreased medial prefrontal cortex (mPFC) rats. suppressed due transporter-3 (GLUT3) expression, abundant and specific...
The genus Euglena contains more than 1000 species of single-celled flagellated microorganisms with both plant and animal characteristics. As a model organism, E. gracilis has been studied well to address fundamental questions in chloroplast development photosynthesis, implications physiology, biochemistry cell biology (Schwartzbach Shigeoka, 2017). However, research bioengineering biotechnology Euglena, especially using genome editing, remains insufficient (Figure 1a). Nomura et al. (2019)...
The context and purpose of the study included 1) bacterial expression viral protein 6 (VP6) porcine rotavirus (PRV) generation rabbit polyclonal antiserum to VP6 protein; 3) establishment a discrimination ELISA distinguish PRV from panel other viruses.The gene isolate DN30209 amplified by reverse transcription-PCR was 1356 bp containing complete open reading frame (ORF) encoding 397 amino acids. Sequence comparison phylogenetic analysis indicated that may belong group A rotavirus....
Previous studies have shown that the combination of mesenchymal stem cell (MSC) transplantation and electroacupuncture (EA) stimulation is a neuroprotective strategy for treating intracerebral hemorrhage (ICH). However, underlying mechanisms by which combined treatment promotes neuroprotection remain unclear. This study was designed to investigate effects on synaptic plasticity elucidate their mechanisms. Therefore, rat ICH models were established injecting collagenase heparin, animals...
The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its Omicron subvariants drastically amplifies transmissibility, infectivity, immune escape, mainly due to their resistance most neutralizing antibodies. Thus, exploring the mechanisms underlying antibody evasion is crucial. Although full-length native form antibody, immunoglobulin G (IgG), offers valuable insights into neutralization, structural investigations primarily focus on fragment antigen-binding (Fab)....