A5012230637- Veterinary Oncology Research
- Folate and B Vitamins Research
- Clostridium difficile and Clostridium perfringens research
- Veterinary Medicine and Surgery
- Gut microbiota and health
- Veterinary Equine Medical Research
- Intestinal Malrotation and Obstruction Disorders
- Metabolism and Genetic Disorders
- Congenital Anomalies and Fetal Surgery
- Porphyrin Metabolism and Disorders
- Clinical Nutrition and Gastroenterology
- Viral gastroenteritis research and epidemiology
- Pediatric Hepatobiliary Diseases and Treatments
- Mycobacterium research and diagnosis
- Animal health and immunology
- S100 Proteins and Annexins
- Infant Nutrition and Health
- Pancreatitis Pathology and Treatment
- Tissue Engineering and Regenerative Medicine
- Otolaryngology and Infectious Diseases
- Intestinal and Peritoneal Adhesions
- Hedgehog Signaling Pathway Studies
- Gastrointestinal motility and disorders
- Foreign Body Medical Cases
- Antibiotic Use and Resistance
Helsingborgs lasarett
2008-2025
Texas A&M University
2008-2025
University of Helsinki
2015-2024
Finnish Society of Sciences and Letters
2021
Finnish Veterinary Foundation
2016-2017
Background Recent molecular studies have revealed a highly complex bacterial assembly in the canine intestinal tract. There is mounting evidence that microbes play an important role pathogenesis of acute and chronic enteropathies dogs, including idiopathic inflammatory bowel disease (IBD). The aim this study was to characterize microbiota dogs with various gastrointestinal disorders. Methodology/Principal Findings Fecal samples from healthy (n = 32), non-hemorrhagic diarrhea (NHD; n 12),...
Mounting evidence from human studies suggests that bile acid dysmetabolism might play a role in various chronic gastrointestinal diseases. It is unknown whether fecal occurs dogs with inflammatory enteropathy (CE).To assess microbial dysbiosis, unconjugated acids (fUBA), and disease activity steroid-responsive CE.Twenty-four healthy control 23 CE.In this retrospective study, fUBA were measured analyzed. Fecal microbiota assessed using dysbiosis index. The canine bowel index was used to...
Chronic enteropathies (CE) are common in dogs, but not all affected dogs respond to standard therapy. Successful responses faecal microbial transplantation (FMT) with non-responsive CE have been reported two case series. The objective of this retrospective study was describe the clinical effects FMT as an adjunctive therapy a larger population CE. Forty-one aged 0.6-13.0 years (median 5.8) under treatment for at one referral animal hospital were included. Dogs treated 1-5 3) FMTs rectal...
Background Cobalamin deficiency is commonly associated with chronic enteropathies ( CE ) in dogs and current treatment protocols recommend parenteral supplementation. In humans, several studies have reported equal efficacy of oral cobalamin administration cobalamin. Objectives To retrospectively evaluate whether supplementation can restore normocobalaminemia hypocobalaminemia. Animals Fifty ‐ one client‐owned various signs Material Methods Retrospective study based on a computerized database...
DNA shotgun sequencing is an untargeted approach for identifying changes in relative abundances, while qPCR allows reproducible quantification of specific bacteria. The canine dysbiosis index (DI) assesses the fecal microbiota by using a mathematical algorithm based on results. We evaluated correlation between and samples from 296 dogs with different clinical phenotypes. While significant correlations were found sequencing, certain taxa only detectable not sequencing. Based less than 2%...
Bile acids (BAs) are important signaling molecules in the gastrointestinal (GI) tract and associated with health disease humans animals. Intestinal bacteria transform BA through deconjugation, dehydroxylation, epimerization reactions, producing various isoforms, many of which have not been investigated companion animal diseases. We aimed to develop analytically validate a novel liquid chromatography–tandem mass spectrometry (LC-MS/MS) method for quantification 30 BAs dog feces, simple...
In humans, the risk of contracting cryptosporidiosis caused by Cryptosporidium felis is considered to be relatively low, and most confirmed cases have been observed in immunocompromised patients. Both anthroponotic zoonotic transmission routes suggested. Here, we report a case suspected C. from cat human. The developed diarrhea several months before such symptoms were displayed its owner, 37-year-old immunocompetent woman. presence identical SSU rRNA, HSP70, COWP gene sequences was verified...
Objectives The objective of the study was to evaluate whether oral cobalamin supplementation can restore normocobal-aminaemia in cats with hypocobalaminaemia and clinical signs gastrointestinal disease. Methods This a retrospective based on computerised database search for client-owned treated at Evidensia Specialist Animal Hospital, Helsingborg, Sweden, during period December 2013 August 2016. Inclusion criteria were chronic enteropathy, an initial serum concentration ⩽250 pmol/l (reference...
Abstract Background In people, bile acid diarrhoea is a prevalent complication of Crohn’s disease and diarrhoea-associated irritable bowel syndrome. Affected patients typically respond to sequestrants, such as cholestyramine, but human gastroenterologists often fail recognize diarrhoea. Consequently, regarded an underrecognized undertreated condition in medicine. Due lack diagnostic tools, clinical response sequestrants used confirm diagnosis people. Several recent studies have shown that...
Cobalamin deficiency is a common sequela of chronic enteropathies (CE) in dogs. Studies comparing the intestinal microbiome CE dogs with cobalamin to those that are normocobalaminemic lacking. Therefore, our aim was describe fecal prospective, comparative study evaluating 29 and deficiency, 18 normocobalaminemia, 10 healthy control Dogs were also analyzed after oral or parenteral supplementation. Overall composition (beta diversity) at baseline significantly different when compared...
Objectives The purpose of this study was to evaluate the diagnostic sensitivity and specificity preputial cytology in oestrogen producing testicular tumours dogs. Methods Forty‐five dogs with palpable masses 30 healthy control were included. Dogs evaluated for signs alopecia and/or feminisation. Analyses cytology, haematology serum oestradiol performed. neutered testes submitted histopathological examination. divided into three groups (1) (n=30), (2) a mass concentration <40 pmol/L...
Fecal S100/calgranulin (S100A12 and calprotectin) concentrations are useful markers of gastrointestinal inflammation in dogs. In people, fecal affected by age, obesity, diet other lifestyle factors. Knowledge about the effects such factors on dogs is currently scarce.To evaluate association between several a large cohort healthy adult dogs.Single-spot samples from 181 pet data derived standard questionnaire served to effect sex, reproductive status, body weight condition, breed type size,...
Canine gastroenteritis (CGE) is a common cause for seeking veterinary care in companion animal medicine and an area where antibiotics have been reported to be widely used. Therefore, creating relevant benchmarks antibiotic use CGE important when implementing analyzing stewardship interventions. The aim of this paper was describe the level temporal trend systemic Sweden between 2020 2023.
Abstract Pyometra is a prevalent disease in intact bitches and the standard treatment ovariohysterectomy (OHE). Published descriptions of normal sonographic findings after OHE are currently lacking. The aims this prospective observational study were to describe compare postoperative abdominal features for three timepoints following group dogs with pyometra an uneventful recovery. A total 22 had sequential focused ultrasound examinations on days 1, 4–6, 10–15 postsurgery. Recorded each...
Chronic pancreatitis (CP) is a common disease in middle-aged to older cats. Cyclosporine has been suggested as an alternative treatment when other immunosuppressive treatments are insufficient or contraindicated. However, no published studies have investigated its efficacy on feline CP. The aim of this retrospective study was evaluate the cyclosporine supranormal serum pancreas-specific lipase (Spec fPL) concentrations cats with presumed Inclusion criteria were history and clinical signs...