A5008560545- Radiation Therapy and Dosimetry
- Radiation Detection and Scintillator Technologies
- Particle Detector Development and Performance
- Radiation Effects in Electronics
- Electronic and Structural Properties of Oxides
- Magnetic and transport properties of perovskites and related materials
- Ferroelectric and Piezoelectric Materials
- Nuclear Physics and Applications
- Semiconductor materials and devices
- Medical Imaging Techniques and Applications
- Advancements in Photolithography Techniques
- Electron and X-Ray Spectroscopy Techniques
- AI in cancer detection
- Health and Medical Research Impacts
- Nuclear reactor physics and engineering
- Photonic and Optical Devices
- Advances in Oncology and Radiotherapy
- Smart Materials for Construction
- Advanced Photonic Communication Systems
- Photocathodes and Microchannel Plates
- Optical Coatings and Gratings
- Advanced Radiotherapy Techniques
- Digital Radiography and Breast Imaging
- Breast Cancer Treatment Studies
- Mechanical Engineering and Vibrations Research
Fondazione Bruno Kessler
2024
University of Turin
2020-2024
Istituto Nazionale di Fisica Nucleare, Sezione di Torino
2020-2024
Istituto Nazionale di Fisica Nucleare
2020-2022
Universidade Estadual de Santa Cruz
2022
Objective. In this study we introduce spatiotemporal emission reconstruction prompt gamma timing (SER-PGT), a new method to directly reconstruct the photon in space and time domains inside patient proton therapy.Approach. SER-PGT is based on numerical optimisation of multidimensional likelihood function, followed by post-processing results. The current approach relies specific implementation maximum-likelihood expectation maximisation algorithm. robustness guaranteed complete absence any...
Monitoring Ultra-High Dose Rate (UHDR) beams is one of the multiple challenges posed by emergent FLASH radiotherapy. Technologies (i.e., gas-filled ionization chambers) nowadays used in conventional radiotherapy are no longer effective when applied to UHDR regimes, due recombination effect they affected by, and time required collect charges. Exploiting expertise field silicon sensors’ applications into clinics, medical physics group University INFN Torino investigating thin sensors as...
The emergent FLASH RadioTherapy (RT) uses ultrahigh dose-rate irradiation (up to 107 Gy/s instantaneous in each μs pulse) deliver a single high dose of very short time (less than 200 milliseconds). Pre-clinical studies at dose-rates recently showed an increased ratio between tumoricidal effect and normal tissue toxicity (therapeutic index), compared conventional RT standard Gy/min dose-rates. If confirmed by biological vivo validations, this could represent breakthrough cancer treatment....
Irradiations at Ultra-High Dose Rate (UHDR) regimes, exceeding 40 Gy/s in single fractions lasting less than 200 ms, have shown an equivalent antitumor effect compared to conventional radiotherapy with reduced harm normal tissues. This work details the hardware and software modifications implemented deliver 10 MeV UHDR electron beams a linear accelerator Elekta SL 18 MV beam characteristics obtained. GafChromic EBT XD films Advanced Markus chamber were used for dosimetry characterization,...
Objective. The performance of silicon detectors with moderate internal gain, named low-gain avalanche diodes (LGADs), was studied to investigate their capability discriminate and count single beam particles at high fluxes, in view future applications for characterization on-line monitoring proton therapy.Approach. Dedicated LGAD an active thickness 55μm segmented 2 mm2strips were characterized two Italian proton-therapy facilities, CNAO Pavia the Proton Therapy Center Trento, beams provided...
Abstract Background The beam energy is one of the most significant parameters in particle therapy since it directly correlated to particles’ penetration depth inside patient. Nowadays, range accuracy guaranteed by offline routine quality control checks mainly performed with water phantoms, 2D detectors PMMA wedges, or multi‐layer ionization chambers. latter feature low sensitivity, slow collection time, and response dependent on external parameters, which represent limiting factors for...
Abstract The University of Torino (UniTO) and the National Institute for Nuclear Physics (INFN-TO) are investigating use Ultra Fast Silicon Detectors (UFSD) beam monitoring in radiobiological experiments with therapeutic proton beams. single particle identification approach solid state detectors aims at increasing sensitivity reducing response time conventional devices, based on gas detectors. Two prototype systems being developed to count number particles measure energy time-of-flight (ToF)...
Fast procedures for the beam quality assessment and monitoring of energy modulations during irradiation are among most urgent improvements in particle therapy. Indeed, online measurement could allow assessing range penetration treatments, encouraging development new dose delivery techniques moving targets. Towards this end, proof concept a device, able to measure few seconds clinical proton beams (from 60 230 MeV) from Time Flight (ToF) protons, is presented. The prototype consists two Ultra...
We present an analysis of the fluence profile at JSI TRIGA neutron reactor facility in Ljubljana. For study, multi-pad Low-Gain Avalanche Diodes (LGADs) are used. The deactivation acceptor doping gain layer implant due to irradiation, typical LGAD devices, is exploited map inside irradiation channels. amount active extracted via capacitance-voltage measurements for each pad before and after a 1.5×1015n˙eq/cm2, where neq stands 1 MeV equivalent count, providing precise prompt measurement...
Single ion counting in particle therapy may lead to new beam monitoring systems, enabling innovative delivery strategies that are faster and more sensitive than those currently used clinics. Previous studies carried out by the University National Institute of Nuclear Physics (INFN) Turin have demonstrated feasibility using thin silicon detectors count single protons clinical beams (Monaco et al., 2023) [1]. The aim this work is report performance a strip-segmented 60-μm thick PIN sensor for...
Abstract A proton counter prototype based on Low Gain Avalanche Detector (LGAD) technology is being developed for the online monitoring of fluence rate therapeutic beams. The laboratory characterization thin (45 μm and 60 μm) LGAD sensors segmented in 146 strips with an unprecedented large area 2.6 × cm 2 , covering entire beam cross-section, presented discussed. production includes 14 wafers different characteristics, designed produced at Fondazione Bruno Kessler (FBK) Trento 2020. was...
Abstract The University and the National Institute for Nuclear Physics of Torino are developing LGAD-based prototypes beam monitoring in proton therapy. direct measurement single particles could overcome some features currently used ionization chambers, such as slow charge collection reduced sensitivity, which limit implementation advanced delivery techniques (e.g. rescanning). LGAD strip sensors have been designed produced by Bruno Kessler Foundation (FBK, Trento) specifically this project....
A prototype of proton counter was developed by the University and National Institute for Nuclear Physics Torino to be used as online fluence beam monitor in particle therapy. The single identification approach aims at increasing sensitivity readout speed with respect state-of-the-art gas ionization chambers. sensitive area is 2,7 x cm^2 cover clinical cross section characterized a full width half maximum about 1 cm isocenter. sensor thin Low Gain Avalanche Diode segmented 146 strips 180...