A5018051294- Chronic Kidney Disease and Diabetes
- COVID-19 Clinical Research Studies
- Diabetes Treatment and Management
- Cardiac Imaging and Diagnostics
- Renal and Vascular Pathologies
- Pituitary Gland Disorders and Treatments
- Nitric Oxide and Endothelin Effects
- Muscle metabolism and nutrition
- Adrenal Hormones and Disorders
- Renal Diseases and Glomerulopathies
- Long-Term Effects of COVID-19
- Sepsis Diagnosis and Treatment
- Hormonal Regulation and Hypertension
- Blood Pressure and Hypertension Studies
- Cardiac electrophysiology and arrhythmias
- Cardiovascular Health and Disease Prevention
- Adrenal and Paraganglionic Tumors
- Thermal Regulation in Medicine
- Healthcare cost, quality, practices
- Bariatric Surgery and Outcomes
- Ultrasound in Clinical Applications
- Genetic and Kidney Cyst Diseases
- Renin-Angiotensin System Studies
- Diet and metabolism studies
- Emergency and Acute Care Studies
University of Padua
2003-2023
Ospedale Castelfranco Veneto
2002
University of Sassari
2002
Type 2 diabetes is frequently associated with an inflammatory status; the relationships between low-grade inflammation and diabetic nephropathy are still unclear. The aim of this study was to evaluate acute-phase markers inflammation, glomerular structure, albumin excretion rate (AER) in type diabetes. In 74 patients (23 normoalbuminuric, 30 microalbuminuric, 21 proteinuric) fibrinogen, serum amyloid A protein (SAA), C-reactive (CRP), IL-6 were determined. AER measured on three 24-h urine...
Podocyte structural changes have been suggested to be involved in the pathogenesis of albuminuria diabetes. We evaluated podocytes density, number, and structure 67 white patients with type 2 diabetes: 21 normoalbuminuric (NA), 23 microalbuminuric (MA), proteinuric (P). Kidney function biopsy studies were performed; 20 kidney donors served as control subjects. Electron microscopic morphometric analysis was used estimate numerical density per glomerulus [Nv(epi/glom)], filtration slit length...
BackgroundHydroxychloroquine and azithromycin combination therapy is often prescribed for coronavirus disease 2019 (COVID-19). Electrocardiographic (ECG) monitoring warranted because both medications cause corrected QT-interval (QTc) prolongation. Whether QTc duration significantly varies during the day, potentially requiring multiple ECGs, remains to be established.MethodsWe performed 12‑lead ECGs 24-h Holter ECG in all patients aged <80 years admitted our medical unit COVID-19, oral with...
Abstract Backgrounds Patients at greatest risk of severe clinical conditions from coronavirus disease 2019 (COVID-19) and death are elderly comorbid patients. Increased levels cardiac troponins identify patients with poor outcome. The present study aimed to describe the characteristics outcomes a cohort Italian inpatients, admitted medical COVID-19 Unit, investigate relative role injury on in-hospital mortality. Methods results We analyzed all consecutive laboratory-confirmed referred our...
ABSTRACT. Prospective studies have established smoking as an independent risk factor for diabetic nephropathy, suggesting adverse effect of on glomerular structure and function. To test this hypothesis, study evaluated GFR, metabolic profile, habits in 96 patients with type 2 diabetes abnormal albumin excretion rate (AER). All underwent percutaneous kidney biopsy: mesangial fractional volume [Vv (mes/glom)] basement membrane (GBM) width were estimated by electron microscopic morphometric...
OBJECTIVE: Vascular endothelial growth factor (VEGF) exists in three main splice variants, characterized by 121, 165 and 189 amino acids (VEGF VEGF 189) acts via two specific receptors: VEGF-R1 or Flt-1 VEGF-R2 KDR. plays an important role the pathogenesis of diabetic retinopathy. This study examined relationship between its isoforms severity nephropathy type 2 diabetes. DESIGN: We evaluated glomerular gene expression receptors studied relationships with renal functional structural...
Genetic factors are important in conferring diabetic nephropathy (DN) risk. The insertion/deletion (I/D) polymorphism of the ACE gene has been described to be associated with DN risk and progression. renal lesions underlying type 2 diabetes heterogeneous; only a subset patients, characterized by faster decline function, have glomerulopathy. This study explored relations between glomerulopathy genotype distribution 77 patients an albumin excretion rate > or = 20 microg/min. Using morphometric...
Acromegaly is a rare disease with peak of incidence in early adulthood. However, enhanced awareness this disease, combined wide availability magnetic resonance imaging (MRI), has increased the diagnosis forms mild presentation, especially elderly patients. Moreover, due to life expectancy and proactive individualized treatment, patients early-onset acromegaly are today aging. The aim our study was describe cohort acromegaly.This cross-sectional retrospective 96 outpatients. Clinical,...
Background and Aim. Lung ultrasound (LUS) is a convenient imaging modality in the setting of coronavirus disease-19 (COVID-19) because it easily available, can be performed bedside repeated over time. We herein examined LUS patterns relation to disease severity stage among patients with COVID-19 pneumonia. Methods. retrospective case series analysis confirmed SARS-CoV-2 infection who were admitted hospital recorded history, clinical parameters medications. was scored standardized fashion by...
Summary Background and aim Patients with adrenal insufficiency ( AI ) require lifelong glucocorticoid GC replacement therapy. Cortisol measurement in saliva is increasingly being used: we assessed salivary cortisol rhythm outpatients , to provide new insights regarding the management of treatment. Materials methods Nineteen collected six samples from awakening (F a before taking morning therapy), during day 1.5 h F 6 afternoon dose, 8.5 12 until bedtime b ). We measured daily exposure by...
Central adrenal insufficiency (CAI) in acromegaly may be related to pituitary adenoma or induced by various medical treatments, transsphenoidal neurosurgery (TNS) radiotherapy (RT), alone combined. We assessed the role of all available treatments for inducing CAI. retrospectively studied 97 patients. CAI was diagnosed if morning serum cortisol <138 nmol/l, its response inadequate low-dose short synacthen test. Seventy-four subjects underwent TNS (and 17 whom also RT), and 23 were on primary...
OBJECTIVE: To evaluate endothelial function in type 2 diabetic patients with and without nephropathy. METHODS: We studied the effects of systemic infusion nitric oxide (NO) synthase inhibitor NG-monomethyl-l-arginine (L-NMMA) on cardiovascular renal hemodynamics six microalbuminuria (D2-MA), normoalbuminuria (D2-NA) five control subjects. Both subjects had mild arterial hypertension. RESULTS: L-NMMA decreased cardiac index all groups. A reduction glomerular filtration rate (GFR) an increase...
Background: The correction of iron deficiency (ID) with ferric carboxymaltose (FCM) is a recommended intervention in heart failure (HF) reduced ejection fraction. Our aim to evaluate, real-life setting, the clinical significance ID screening and FCM treatment acute decompensated HF (ADHF). Methods: In cohort ADHF patients, prevalence administration were investigated. Among 104 patients admitted for ADHF, n = 90 (median age 84, 53.5% preserved left ventricular fraction-LVEF), complete status...
Rapid intensive observation (RIO) units have been created to guarantee high standards of care in a sustainable health-care system. Within short stay (SSUs), which are subgroup RIOs, only rapidly manageable patients should be admitted. Physicians unable predict the length (LOS) as objective criteria make such prediction missing. A retrospective observational study was carried out identify for admission within cardiovascular care-oriented SSU. Over period 317 days, 340 (age 69.4 ± 14.7 years)...