Polycystic ovary syndrome (PCOS) is characterized by cystogenesis; however, the cause of this cystogenesis unknown. At ovulation, preovulatory collagenolytic activities in ovarian follicles increase and various proteinases are needed to degrade tissues surrounding follicles. To clarify roles enzymes collagen degradation follicular wall polycystic (PCO) relation cystogenesis, we examined expression lysyl oxidase (LOX), which initiates cross-link formation elastin extracellular matrix, matrix...

The first optical single-carrier (SC) transmission system to employ frequency-domain equalisation (FDE) is proposed; 25 Gbit/s SC with FDE demonstrated in severe chromatic dispersion conditions. results show that very tolerant of the dispersion.

Experimental results are presented for an 8times2 multiple-input multiple-output (MIMO) channel in actual cellular environment. This paper focuses particular on the characteristics of capacity based number antennas and difference antenna polarizations, i.e., vertical, vertical horizontal, slanted plusmn45deg, at both base terminal stations. The configuration with plusmn45deg polarization achieves highest when array is less than four signal-to-noise ratio (SNR) from 5 to 40 dB outdoor...

Recent analysis of the codon-72 polymorphism p53 gene, allele encoding proline or arginine, suggested that homozygous Arg/Arg genotype is a significant risk factor for cervical cancer associated with human papillomavirus (HPV). We investigated in condylomas, intraepithelial neoplasias (CINs), and cancers, evaluating clinical implications development neoplasms. DNA from 87 tissues, 28 CIN seven condyloma tissues were examined presence HPV by consensus PCR method was analyzed using an...

To examine the correlations between ras oncogene expression and development of cervical cancer, authors studied reactivity intraepithelial neoplasia (CIN) microinvasive lesions human uterine cervix by using anti-ras p21 mouse monoclonal antibody rp35. The frequency positive staining increased with grades malignancy from 17.9% in CIN 1 to 28.9% 2 53.9% 3, whereas carcinoma it was 50.0%. Furthermore, ten cases that regressed during a 1-year follow-up period were for 20% cases, but 14...

We demonstrate an experimental comparison of the bond lifetime, estimated using surface plasmon resonance (SPR), and viscoelastic relaxation time transient networks with well-controlled structures (dynamically cross-linked Tetra-PEG gel). SPR measurements revealed that temperature dependences two characteristic times are in agreement, while response is delayed respect to lifetime by a factor 2–3, dependent on network strand length. Polymers temporary interactions form networks, which show...

Gonadotropin-releasing hormone (GnRH) and its agonist analog (GnRHa) are well known to have luteolytic effects. We previously reported that prolactin (PRL) stimulated matrix metalloproteinase (MMP)-2 activity degrade collagen type IV as a mechanism of structural luteolysis. The effects GnRHa treatment on developed corpora lutea unknown. In this study we assessed the effect GnRH MMP expression induction involution superovulated rats using GnRHa. Pregnant mare serum gonadotropin-human...

A series of novel phthalocyanine derivatives with bulky electron-donating thioether substituents were synthesized in order to investigate the effect sulfur atoms on solar-cell performances Zn–phthalocyanine based dye-sensitized solar cells.

The swelling dynamics of polymer gels are characterized by the (collective) diffusion coefficient D network. Here, we measure temperature dependence with controlled homogeneous network structures using dynamic light scattering. An evaluation at gelation point D_{gel} and increase therein as proceeds ΔD≡D-D_{gel} indicates that ΔD is a linear function absolute significantly large negative constant term. This feature formally identical to recently discovered "negative energy elasticity" [Y....

We previously reported that the 70-kDa heat shock cognate protein-like molecule (hsc70) is expressed on cell surface along with neoplastic transformation of rat fibroblast and this recognized by CD3+, CD4-, CD8-, NKR-P1-, TCR-alphabeta- T (DNT) killer cells in an MHC class I-unrestricted fashion. investigated mechanism interaction between hsc70 DNT cells. H-ras oncogene-transformed fibrosarcoma W31 almost same density when were growing a conventional 5% FCS (5% W31) as growth was inhibited...

Processing technology using an extreme ultraviolet light source, e.g., next-generation lithography, requires high-accuracy mirrors. As it will be difficult to attain the degree of precision required by mirrors such as aspherical through conventional processing methods, rapid progress in nanomeasurement technologies needed produce Because measuring methods used for surface figure measurement require high precision, we have developed a novel nanoprofiler that can measure figures without use...

5002 Background: Optimal adjuvant therapy for intermediate risk endometrial cancer patients is poorly defined. Methods: A Japan Gynecologic Oncology Group (JGOG) conducted a multi-center randomized Phase III trial of whole pelvic irradiation (WPI) vs. cyclophosphamide-doxorubicin-CDDP (CAP) chemotherapy in women with carcinoma deeper than 50% myometrial invasion postoperatively. 425 pts were entered from 1/1994 to 12/2000. Of the 385 evaluable endometrioid adenocarcinoma, 193 receive WPI and...

We demonstrated 25-Gb/s (21.7-Gb/s after coding) single-carrier (SC) transmission with QPSK format over 240 km of SMF (4080 ps/nm) by employing frequency-domain equalization (FDE).

The transmission performance of optical single-carrier (SC) using frequency-domain equalisation (FDE) to counter polarisation mode dispersion (PMD) is evaluated. 25 Gbit/s coherent SC FDE (CO-SC-FDE) demonstrated in the presence a significant amount differential group delay (DGD). results show that CO-SC-FDE compensates for influence 125 ps DGD; OSNR penalty 0.81 dB.

The effect of network connectivity on viscoelastic relaxation in transient networks with well-defined structures (Tetra-PEG slime) was experimentally evaluated and compared to bond dissociation kinetics. To control the discuss pure precisely, we mixed precursors off-stoichiometric ratio. With decreasing connectivity, time accelerated became shorter than time. increasing polymer concentration, at which matched shifted high-connectivity region. dependence can be adequately explained within...

A retrospective analysis was made of 1044 patients with gynecologic malignancies treated in our department over a 12-year period, order to review the frequency and types multiple primary neoplasms. Multiple neoplasms were detected 45 (4.3%) cases, including 16 (2.1%) out 733 cervical cancers, 14 (8.2%) 166 endometrial three (15%) 20 vaginal cancers 12 (9.8%) 123 ovarian cancers. Fifteen cases synchronous remaining 24 heterochronous, an average 4.9-year interval. The most frequent other site...

The human corpus luteum produces both estradiol and progesterone. It is well known that there are autocrine paracrine systems for the regulation of regulates progesterone production corpora lutea some other species. To assess direct effects estrogen on luteal function, we performed cell culture experiments.A low concentration estradiol, almost equal to amount produced by cultured cells, directly stimulated production. 4-Cyclohexylaniline, an aromatase inhibitor, significantly reduced...

It is unclear if women who develop uterine leiomyomas have had menstrual regularity or irregularity in their reproductive life. This case-control study examines the recalled cycle patterns throughout life among requiring hysterectomy for myomas. One hundred twenty-two with myomas and 244 age-matched healthy controls without were enrolled Japan. The incidence of normal pattern teens patients myoma was significantly higher than that (p < 0.01). subset results parous same as those all subjects....