A5008049623- Hydrogels: synthesis, properties, applications
- Advanced Sensor and Energy Harvesting Materials
- Advanced Polymer Synthesis and Characterization
- Retinal Development and Disorders
- biodegradable polymer synthesis and properties
- Electrospun Nanofibers in Biomedical Applications
- Sperm and Testicular Function
- Reproductive Biology and Fertility
- Neuroscience of respiration and sleep
- Material Dynamics and Properties
- Spectroscopy Techniques in Biomedical and Chemical Research
- Optical Imaging and Spectroscopy Techniques
- Surgical Sutures and Adhesives
- Advanced Materials and Mechanics
- RNA Interference and Gene Delivery
- Hemostasis and retained surgical items
- Heart Rate Variability and Autonomic Control
- Lipid Membrane Structure and Behavior
- Wound Healing and Treatments
- Advanced Thermodynamics and Statistical Mechanics
- Hypothalamic control of reproductive hormones
- Clusterin in disease pathology
- Antioxidant Activity and Oxidative Stress
- Leprosy Research and Treatment
- Neurological diseases and metabolism
The University of Tokyo
2008-2023
Kwansei Gakuin University
2020
Katsumata Hospital
2019
Graduate School USA
2019
Morinomiya University of Medical Sciences
2018
National Institute of Technology, Nara College
2018
Kanazawa Institute of Technology
2018
Saitama University
2017
Tokyo University of Science
2016
Tokyo University of Agriculture
2004
In the present study we investigated effect of laughter therapy on physiological and psychological function in older people.An open-label trial.Seventeen people who regularly attended an elderly day care centre were recruited. Stand-up comedy as was performed once a week for 4 weeks. Parameters evaluated before after therapy.Laughter intervention resulted significant reduction systolic blood pressure heart rate, accompanied by increase plasma concentration serotonin decrease salivary...
Abstract Pink biofilms are multispecies microbial communities that commonly found in moist household environments. The development of this pink stain is problematic from an aesthetic point view, but more importantly, it raises hygienic concerns because they may serve as a potential reservoir opportunistic pathogens. Although there have been several studies using molecular analysis and confocal laser scanning microscopy, little known about the spatial distributions constituent microorganisms...
Comparison of two methodologies tuning the connectivity AB-type polymerization shows applicability mean-field approximation.
Rubber elasticity is the archetype of entropic force emerging from second law thermodynamics; numerous experimental and theoretical studies on natural synthetic rubbers have shown that originates mostly entropy change with deformation. Similarly, in polymer gels containing a large amount solvent, it has also been postulated shear modulus (the rigidity) $G$, which kind elasticity, approximately equivalent to contribution $G_S$, but this yet be verified experimentally. In study, we measure...
We recently found that the energy contribution to linear elasticity of polymer gels in as-prepared state can be a significant negative value; shear modulus is not proportional absolute temperature [Y. Yoshikawa et al., Phys. Rev. X 11, 011045 (2021) (arXiv:1912.13191)]. Our finding challenges conventional notion polymer-gel mainly determined by entropy contribution. Existing molecular models classical rubber theories, including affine, phantom, and junction affine network models, cannot used...
Abstract The mechanisms by which physical exercise benefits brain functions are not fully understood. Here, we show that vertically oscillating head motions mimicking mechanical accelerations experienced during fast walking, light jogging or treadmill running at a moderate velocity reduce the blood pressure of rats and human adults with hypertension. In hypertensive rats, shear stresses less than 1 Pa resulting from interstitial-fluid flow induced such passive reduced expression angiotensin...
TetraStat is a tetra-armed polyethylene glycol (PEG) hydrogel. It synthetic sealant that solidifies instantly in response to pH changes. This study aimed evaluate the hemostatic effect of through experiments evaluating future clinical applications.We used TetraStat, oxidized regenerated cellulose (SURGICEL®), and fibrinogen thrombin patch (TachoSil®) using vitro vivo experiments. For experiment, closed circulatory system filled with phosphate-buffered saline under high pressure was used....
The swelling dynamics of polymer gels are characterized by the (collective) diffusion coefficient D network. Here, we measure temperature dependence with controlled homogeneous network structures using dynamic light scattering. An evaluation at gelation point D_{gel} and increase therein as proceeds ΔD≡D-D_{gel} indicates that ΔD is a linear function absolute significantly large negative constant term. This feature formally identical to recently discovered "negative energy elasticity" [Y....
Injectable hydrogels are biomaterials that can be administered minimally invasively in liquid form and considered promising artificial extracellular matrix (ECM) materials. However, ordinary injectable synthesized from water-soluble molecules to ensure injectability, resulting non-phase-separated structures, making them structurally different natural ECMs with phase-separated insoluble structural proteins, such as collagen elastin. Here, we propose a simple material design approach impart...
The pathogenesis of progressive spongy degeneration in zitter rats with genetic spongiform encephalopathy was examined histopathologically and biochemically the context edematous change central nervous system (CNS). Histopathological studies revealed that vacuolation CNS progressed aging severity markedly divergent different areas CNS. Edematous confirmed by a consistently higher water content brain than normal SD/J at all ages. Furthermore, close relationship between demonstrated regional...
Mechanical forces are known to be involved in various biological processes. However, it remains unclear whether brain functions mechanically regulated under physiological conditions. Here, we demonstrate that treadmill running and passive head motion (PHM), both of which produce mechanical impact on the head, have similar effects hallucinogenic 5-hydroxytryptamine (5-HT) receptor subtype 2A (5-HT2A) signaling prefrontal cortex (PFC) rodents. PHM generates interstitial fluid movement is...
The first in vitro selection of binding peptides against artificial lipid membranes from a random peptide library using an display method (cDNA display) is reported. selected peptide, LB-1, has both amphiphilic and cationic regions, proteins fused to LB-1 can be immobilized on the liposome surface.
Using immunohistochemistry, we investigated whether daily administration of clenbuterol (CLE; 1 mg/kg body weight per day) accelerates recovery after casted immobilization(IMM)-induced atrophy fast-twitch plantaris and slow-twitch soleus muscles. Adult male Sprague-Dawley rats were assigned to the control (CON), immobilization (IMM), following (RCON), with CLE (RCLE) groups. Casted periods 9 14days, respectively. Rats CON group subjected experiment simultaneously IMM group. Nine days induced...
Dynamics of a polymer gel network is described by the theory proposed Tanaka, Hocker, and Benedek (THB) that gives diffusion coefficient (D=K+43Gf). Here, K osmotic bulk modulus, G shear f friction between solvent. Although several experimental studies investigated dynamics network, THB has yet to be quantitatively validated. In this study, we validate comparing D Tetra-poly(ethylene glycol) gels measured dynamic light scattering viscoelastic measurement. The well linear increase in with...
Because the swelling of polymer gels is a diffusion process network, rate determined by coefficient network. The (D) includes polymer–solvent mixing contribution (Dmix) and elastic from network (Del). In this study, we experimentally investigate D, Dmix, Del, using tetra whose structural parameters are systematically controllable. We measured D shear modulus (G) dynamic light scattering viscoelastic measurement, respectively. According to Tanaka–Fillmore theory, evaluate Dmix Del linear...
Abstract Recently, covering materials for protecting post-endoscopic ulcers are being developed using hydrogels. Existing hydrogels not ideal coating because it is difficult to control their physical properties. Therefore, we conducted an animal pilot study investigate the protective effect of a novel ulcer material, whose properties can be easily controlled and designed. We applied injectable hydrogel artificial induced on gastric mucosa rats. Rats were assigned or group. To measure ulcers,...
Intracytoplasmic sperm injection (ICSI) and partial zona dissection followed by insemination (PZD-I) were used to establish a microinjection system in cynomolgus monkeys (Macaca fascicularis), which are potential models for human reproduction. Two experimental systems studied, either hamster oocytes or monkey as the vehicle. When used, 66 out of 81 ICSI-treated (82%) showed head swelling pronucleus formation. Following PZD-I rates spermatozoa penetration (85/114; 75%) fertilization (71/114;...
ジェット水流による破砕でキトサンナノファイバー懸濁液を作製し，薬剤徐放機能を有する新しい創傷被覆材の開発を試みた．塩化リゾチームの吸着性を検討した結果，キトサンナノファイバーおよび成形体であるフィルムともに単層吸着することがわかった．塩化リゾチーム含有キトサンフィルムを作製し，PBS中への放出特性を検討した結果，塩化リゾチームの累積放出挙動は直線性を示し，キトサンの治療薬徐放機能が確認された．さらに，キトサンナノファイバーをガーゼに塗布することで生体適合性および薬剤徐放機能を有する新しい創傷被覆材を容易に作製できることを示した．
Presented here is a facile and practical method for calibrating anti-Stokes–Stokes intensity ratios in low-frequency Raman spectra that devised specifically temperature measurements inside cells. The proposed uses as an standard the spectrum of liquid water, major molecular component cells, whose independently measured with thermocouple. Rather than pixel intensities themselves, we obtain correction factor at each shift 20–200 cm −1 region by dividing ratio calculated theoretically from...
Abstract Injectable hydrogels are biomaterials that can be administered minimally invasively in liquid form, and considered promising artificial extracellular matrix (ECM) materials. However, ordinary injectable synthesized from water-soluble molecules to ensure injectability, resulting nonphase-separated structures, making them structurally different natural ECMs with phase-separated insoluble structural proteins, such as collagen elastin. Here, we propose a simple material design approach...