A5101950979- Cell death mechanisms and regulation
- Lipid metabolism and biosynthesis
- Physiological and biochemical adaptations
- Growth Hormone and Insulin-like Growth Factors
- Reproductive Physiology in Livestock
- Effects of Environmental Stressors on Livestock
- thermodynamics and calorimetric analyses
- Immune Response and Inflammation
- Peroxisome Proliferator-Activated Receptors
- Mitochondrial Function and Pathology
- Trace Elements in Health
- Cancer Research and Treatments
- TGF-β signaling in diseases
- Reproductive System and Pregnancy
- Meat and Animal Product Quality
- Ubiquitin and proteasome pathways
- Cardiac Fibrosis and Remodeling
- Muscle Physiology and Disorders
- MicroRNA in disease regulation
- Magnetic and Electromagnetic Effects
- Cardiac Ischemia and Reperfusion
- Bone Metabolism and Diseases
- GDF15 and Related Biomarkers
- Selenium in Biological Systems
- Molecular Biology Techniques and Applications
Huazhong Agricultural University
2008-2016
Hydrogen peroxide is currently the most widely used apoptosis inducer due to its broad cytotoxic efficacy against nearly all cell types. However, equivalent cytotoxicity achieved over a wide range of doses, although reasons for this differential sensitivity are not always clear. In study, three kinds cells, 293T line, primary fibroblasts, and terminally differentiated myocardial were treated with H 2 O doses. Times initiation end measured cytochemically changes in expression caspase-9, P53,...
Chronic enteritis can produce an excess of reactive oxygen species resulting in cellular damage. Stanniocalcin-1(STC-1) reportedly possesses anti-oxidative activity, the aim this study was to define more clearly direct contribution STC-1 stress cattle. In study, primary intestinal epithelial cells (IECs) were exposed hydrogen peroxide (H2O2) for different time intervals mimic chronic enteritis-induced Prior treatment with 200 µM H2O2, transfected a recombinant plasmid 48 h over-express...
Stanniocalcin-1 (STC1) is a calcium and phosphate regulatory hormone. However, the exact molecular mechanisms underlying how STC1 affects Ca(2+) uptake remain unclear. Here, expression levels of transport proteins involved in transcellular Caco2 cells were examined following over-expression or inhibition STC1. These include transient receptor potential vanilloid members (TRPV) 5 6, plasma membrane ATPase 1b (PMCA1b), sodium/calcium exchanger (NCX1), vitamin D (VDR). Both gene protein...
Apoptosis repressor with caspase recruitment domain (ARC) is highly involved in apoptosis induced by oxidative stress or ischaemia/reperfusion injury. Furthermore, even though the exact mechanism still unknown, some studies suggest that exogenous ARC also possesses anti-apoptotic ability. The study investigated whether mouse-derived acquires ability and pathway of regulation chick embryo cardiomyocytes. To evaluate can inhibit cardiomyocyte hydrogen peroxide, recombinant pcDNA3.1/ARC plasmid...
Hydrogen peroxide (H2O2) is both an exogenous and endogenous cytotoxic agent that can reliably induce apoptosis in numerous cell types for studies on signaling pathways. However, little known of these apoptotic processes myocardial cells chicken, a species prone to progressive heart failure. Sequencing mRNA transcripts (RNA-Seq) allows the identification differentially expressed genes under various physiological pathological conditions elucidate molecular pathways involved, including...