A5029448913- Gut microbiota and health
- Parasites and Host Interactions
- Clostridium difficile and Clostridium perfringens research
- Parasitic Infections and Diagnostics
- Parasitic Diseases Research and Treatment
- Probiotics and Fermented Foods
- Insect symbiosis and bacterial influences
- Child Nutrition and Water Access
- Helminth infection and control
- Nephrotoxicity and Medicinal Plants
- IL-33, ST2, and ILC Pathways
- Animal Nutrition and Physiology
- Garlic and Onion Studies
- Mast cells and histamine
- Insects and Parasite Interactions
- Microscopic Colitis
- Insect Utilization and Effects
- Parasite Biology and Host Interactions
- Plant and animal studies
- Public Health and Nutrition
- Neurobiology and Insect Physiology Research
- Religion, Society, and Development
- Food Security and Health in Diverse Populations
- Genomics, phytochemicals, and oxidative stress
- Vitamin D Research Studies
University of Copenhagen
2018-2024
University of Oxford
2022
Liverpool School of Tropical Medicine
2016-2019
Nematodes causing lymphatic filariasis and onchocerciasis rely on their bacterial endosymbiont, Wolbachia, for survival fecundity, making Wolbachia a promising therapeutic target. Here we perform high-throughput screen of AstraZeneca's 1.3 million in-house compound library identify 5 novel chemotypes with faster in vitro kill rates (<2 days) than existing anti-Wolbachia drugs that cure filariasis. This industrial scale anthelmintic neglected tropical disease (NTD) screening campaign is the...
Abstract Lymphatic filariasis (LF) and onchocerciasis are priority neglected tropical diseases targeted for elimination. The only safe drug treatment with substantial curative activity against the filarial nematodes responsible LF ( Brugia malayi, Wuchereria bancrofti ) or Onchocerca volvulus is doxycycline. target of doxycycline essential endosymbiont, Wolbachia. Four to six weeks therapy achieves >90% depletion Wolbachia in worm tissues leading blockade embryogenesis, adult sterility...
Diet composition may play a crucial role in shaping host immune responses and commensal gut microbiota populations. Functional foods,Bioactive dietary components, such as inulin, have been extensively studied for their bioactive properties, particularly modulating function reducing inflammation. Recent reports suggestedIt has shown that colonization with gastrointestinal parasitic worms (helminths) alleviate chronic inflammation through promotion of T-helper cell type (Th) 2 T-regulatory...
A series of pleuromutilins modified by introduction a boron-containing heterocycle on C(14) the polycyclic core are described. These analogs were found to be potent anti- Wolbachia antibiotics and, as such, may useful in treatment filarial infections caused Onchocerca volvulus, resulting Onchocerciasis or river blindness, Wuchereria bancrofti and Brugia malayi related parasitic nematodes lymphatic filariasis. two important neglected tropical diseases disproportionately impact patients...
Lymphatic filariasis and onchocerciasis are parasitic helminth diseases, which cause severe morbidities such as elephantiasis, skin disease blindness, presenting a major public health burden in endemic communities. The anti-Wolbachia consortium (A·WOL: http://www.a-wol.com/) has identified number of registered antibiotics that target the endosymbiotic bacterium, Wolbachia, delivering macrofilaricidal activity. Here we use pharmacokinetics/pharmacodynamics (PK/PD) analysis to rationally...
Fermentable dietary fibers promote the growth of beneficial bacteria, can enhance mucosal barrier integrity, and reduce chronic inflammation. However, effects on intestinal type 2 immune function remain unclear. In this study, we used murine whipworm Trichuris muris to investigate effect fermentable fiber inulin host responses infection regimes that distinct Th1 Th2 in C57BL/6 mice. uninfected mice, stimulated such as Bifidobacterium (Actinobacteria) Akkermansia (Verrucomicrobia). Despite...
Dietary probiotics may enhance gut health by directly competing with pathogenic agents and through immunostimulatory effects. These properties are recognized in the context of bacterial viral pathogens, but less is known about interactions eukaryotic pathogens such as parasitic worms (helminths). In this study we investigated whether two probiotic mixtures (comprised Bacillus amyloliquefaciens, B. subtilis , Enterococcus faecium [BBE], or Lactobacillus rhamnosus LGG Bifidobacterium animalis...
Enteric infections induce dysbiosis and inflammation are a major public health burden. As the gut environment is strongly shaped by diet, role of different dietary components in promoting resistance to infection interest. While diets rich fiber or whole grain normally associated with improved health, we show here that these predispose host higher levels pathogen infection. Thus, our results have significance for interpreting how interventions may impact on gastrointestinal infections....
Garlic is a source of bioactive phytonutrients that may have anti-inflammatory or immunomodulatory properties. The mechanism(s) underlying the bioactivity these compounds and their ability to regulate responses enteric infections remains unclear.This study investigates if garlic-derived preparation (PTSO-PTS) containing two organosulfur metabolites, propyl-propane thiosulfonate (PTSO), thiosulfinate (PTS), inflammatory in murine macrophages intestinal epithelial cells (IEC) vitro, as well...
The gut microbiota displays a profound ability to adapt extrinsic factors, such as gastrointestinal pathogens and/or dietary alterations. Parasitic worms (helminths) and host-associated share long co-evolutionary relationship, exerting mutually modulatory effects which may impact the health of host. Moreover, components prebiotic fibres (e.g. inulin) are capable modulating towards composition often associated with healthier function. effect helminth infection on host is still equivocal, it...
Abstract Hyperprolific sows rear more piglets than they have teats, and to accommodate this, milk replacers are often offered as a supplement. Milk based on bovine milk, yet components of vegetable origin added. This may reduce growth, but could also accelerate maturational changes. Therefore, we investigated the effect feeding replacer with gradually increasing levels wheat flour gut enzyme activity immune function compared diet entirely milk. The hypothesis tested was that adding starch...
Phytonutrients such as cinnamaldehyde (CA) have been studied for their effects on metabolic diseases, but influence mucosal inflammation and immunity to enteric infection are not well documented. Here, we show that consumption of CA in mice significantly down-regulates transcriptional pathways connected the small intestine, alters T-cell populations mesenteric lymph nodes. During with helminth Heligomosomoides polygyrus, treatment attenuated infection-induced changes biological cell cycle...
Proanthocyanidins (PAC) are dietary polyphenols with putative anti-inflammatory and immunomodulatory effects. However, whether PAC can regulate type-2 immune function inflammation at mucosal surfaces remains unclear. Here, we investigated if diets supplemented purified modulated pulmonary intestinal responses during infection the helminth parasite Ascaris suum in pigs. A. induced a biased response lung tissues, characterized by granulocytosis, increased Th2/Th1 T cell ratios...
Polyphenols are phytochemicals commonly found in plant-based diets which have demonstrated immunomodulatory and anti-inflammatory properties. However, the interplay between polyphenols pathogens at mucosal barrier surfaces has not yet been elucidated detail. Here, we show that proanthocyanidin (PAC) interact with gut parasites to influence immune function microbial-derived metabolites mice. PAC intake inhibited mastocytosis during infection small intestinal roundworm Heligmosomoides...
Abstract Infection with intestinal whipworms (Trichuris spp.) causes widespread morbidity and may alter responses to enteric extraintestinal coinfections. Here, we show that Trichuris muris infection in mice increases coinfection 2 evolutionary divergent pathogens, the bacterium Citrobacter rodentium helminth Heligmosomoides polygyrus. Coinfection caused reduced weight gain promoted type 1–biased inflammation. In contrast, T. muris–infected were more resistant migrating Ascaris suum larvae...
Abstract Dietary probiotics may enhance gut health by directly competing with pathogenic agents and through immunostimulatory effects. These properties are recognized in the context of bacterial viral pathogens, but less is known about interactions eukaryotic pathogens such as parasitic worms (helminths). In this study we investigated whether two probiotic mixtures (comprised Bacillus amyloliquefaciens, B. subtilis , Enterococcus faecium [BBE], or Lactobacillus rhamnosus LGG Bifidobacterium...
Abstract Background The influence of diet on immune function and resistance to enteric infection disease is becoming ever more established. Highly processed, refined diets can lead inflammation gut microbiome dysbiosis, whilst health-promoting dietary components such as phytonutrients fermentable fibres are thought promote a healthy balanced mucosal immunity. Chicory ( Cichorium intybus ) leafy green vegetable rich in bioactive compounds that may health. Results Unexpectedly, we here show...
Brown seaweeds have a rich bioactive content known to modulate biological processes, including the mucosal immune response and microbiota function, may therefore potential control enteric pathogens. Here, we tested if dietary seaweed (Saccharina latissima) supplementation could pig gut health with specific focus on parasitic helminth burdens, composition, host during five week feeding period in pigs co-infected helminths Ascaris suum Oesophagostomum dentatum. We found that inclusion of...
Abstract Polyphenols are phytochemicals commonly found in plant-based diets which have demonstrated immunomodulatory and anti-inflammatory properties. However, the interplay between polyphenols pathogens at mucosal barrier surfaces has not yet been elucidated detail. Here, we show that proanthocyanidin (PAC) interact with gut parasites to influence immune function microbial-derived metabolites mice. PAC intake inhibited mastocytosis during infection small intestinal roundworm Heligmosomoides...