A5012943086- Helminth infection and control
- Animal Nutrition and Physiology
- Parasite Biology and Host Interactions
- Ruminant Nutrition and Digestive Physiology
- Coccidia and coccidiosis research
- Nematode management and characterization studies
- Genetics, Aging, and Longevity in Model Organisms
- Gut microbiota and health
- Trace Elements in Health
- Genetic and phenotypic traits in livestock
- Plant and fungal interactions
- Veterinary Equine Medical Research
- Selenium in Biological Systems
- Garlic and Onion Studies
- Parasites and Host Interactions
- Rabbits: Nutrition, Reproduction, Health
- Effects of Environmental Stressors on Livestock
- Entomopathogenic Microorganisms in Pest Control
- Legume Nitrogen Fixing Symbiosis
- Pharmacological Effects of Natural Compounds
- Nicotinic Acetylcholine Receptors Study
- Mast cells and histamine
- Nephrotoxicity and Medicinal Plants
- Viral Infections and Immunology Research
- Child Nutrition and Water Access
Archer Daniels Midland (United States)
2023
Infectiologie Animale et Santé Publique
2015-2019
Université de Tours
2016-2018
Institut Agro Rennes-Angers
2007-2009
Université de Rennes
2009
Institut de Génétique, Environnement et Protection des Plantes
2005
Plant NB-LRR proteins confer robust protection against microbes and metazoan parasites by recognizing pathogen-derived avirulence (Avr) that are delivered to the host cytoplasm. Microbial Avr usually function as virulence factors in compatible interactions; however, little is known about types of recognized their relationship with virulence. In this report, we demonstrate secreted protein RBP-1 from potato cyst nematode Globodera pallida elicits defense responses, including cell death...
Cholinergic agonists such as levamisole and pyrantel are widely used anthelmintics to treat parasitic nematode infestations. These drugs elicit spastic paralysis by activating acetylcholine receptors (AChRs) expressed in body wall muscles. In the model Caenorhabditis elegans, genetic screens led identification of five genes encoding levamisole-sensitive-AChR (L-AChR) subunits: unc-38, unc-63, unc-29, lev-1 lev-8. subunits form a functional L-AChR when heterologously Xenopus laevis oocytes....
Gastrointestinal strongyles are a major threat to horses' health and welfare. Given that inhabit the same niche as gut microbiota, they may interact with each other. These beneficial or detrimental interactions unknown in horses could partly explain contrasted susceptibility infection between individuals. To address these questions, an experimental pasture trial 20 worm-free female Welsh ponies (10 susceptible (S) 10 resistant (R) parasite infection) was implemented for five months. Fecal...
Resistance to the anthelmintic macrocyclic lactone ivermectin (IVM) has a great impact on control of parasitic nematodes. The mechanisms by which nematodes adapt IVM remain be deciphered. We have identified NHR-8, nuclear hormone receptor involved in xenobiotic response Caenorhabditis elegans, as new regulator tolerance IVM. Loss-of-function nhr-8(ok186) C. elegans mutants subjected larval development assays and electropharyngeogram measurements, displayed hypersensitivity IVM, silencing...
Ivermectin and moxidectin are the most widely administered anthelmintic macrocyclic lactones (MLs) to treat human animal nematode infections. Their widespread frequent use has led a high level of resistance these drugs. Although they have same mode action, differences in terms selection for drug been reported. Our objective was study compare changes occurring upon ivermectin or model Caenorhabditis elegans C. worms were submitted stepwise exposure increasing doses moxidectin. The sensitivity...
1. This study was conducted to determine the effect of different sources selenium (Se) on breast and liver tissue deposition, apparent metabolisable energy (AME), growth performance antioxidant status broilers, measured as Se content in tissues glutathione peroxidase (GSH-Px) blood, when used 0-35 d broiler chicken diets. 2. A total 200 male Ross 308 broilers were feeding trial, which comprised two dietary phases, a starter from 0 21 finisher 35 age. Four treatments with 10 replications each...
Intestinal strongyles are the most problematic endoparasites of equids as a result their wide distribution and spread resistant isolates throughout world. While abundant literature can be found on extent anthelmintic resistance across continents, empirical knowledge about associated risk factors is missing. This study brought together results from efficacy testing factor analysis to provide evidence-based guidelines in field. It involved 688 horses 39 French horse farms riding schools both...
This study investigated the effect of two supplementation levels zinc glycinate (ZnGly) on performance, carcass characteristics, and meat quality growing-finishing pigs. Thirty pigs (bodyweight: 61 ± 4.0 kg) were assigned to three treatments fed ad libitum for 56 days a diet supplemented with 0 (control), 45 (Zn45), or 100 mg/kg (Zn100) ZnGly. The highest ZnGly lowered average daily gain (P = 0.031); while, cold weight did not differ between treatments. Both reduced chill loss < 0.001)....
Garlic is a source of bioactive phytonutrients that may have anti-inflammatory or immunomodulatory properties. The mechanism(s) underlying the bioactivity these compounds and their ability to regulate responses enteric infections remains unclear.This study investigates if garlic-derived preparation (PTSO-PTS) containing two organosulfur metabolites, propyl-propane thiosulfonate (PTSO), thiosulfinate (PTS), inflammatory in murine macrophages intestinal epithelial cells (IEC) vitro, as well...
This study aimed to investigate the effect of administering a standardized blend cinnamaldehyde, eugenol, and capsicum oleoresin (CEC) lactating dairy cattle for 84 d (i.e., 12 weeks) on enteric CH4 emission, feed intake, milk yield composition, body weight. The experiment involved 56 Holstein-Friesian cows (145 ± 31.1 in at start trial; mean SD) completely randomized block design. Cows were blocked pairs according parity, lactation stage, current yield, randomly allocated 1 2 dietary...
Abstract The study investigated antioxidant effects of Se on resilience to diquat-induced oxidative stress in nursery pigs. Thirty-five weaned pigs were individually housed and randomly assigned one the five treatments. Pigs (1) fed a basal diet intraperitoneally injected with sterile saline (negative control), (2) diquat solution (positive control, PC), or supplemented 0·3 mg Se/kg as (3) sodium selenite (SS), (4) soyabean protein-chelated (SC) (5) selenised yeast (SY) diquat. experimental...
Phytonutrients such as cinnamaldehyde (CA) have been studied for their effects on metabolic diseases, but influence mucosal inflammation and immunity to enteric infection are not well documented. Here, we show that consumption of CA in mice significantly down-regulates transcriptional pathways connected the small intestine, alters T-cell populations mesenteric lymph nodes. During with helminth Heligomosomoides polygyrus, treatment attenuated infection-induced changes biological cell cycle...
Plant extracts (PE) are gaining increased attention as potential alternatives to in-feed antimicrobials (AM) due their known antimicrobial activities. This study was conducted examine the of PE, a microencapsulated product composed eugenol and garlic tincture an alternative AM-agent on performance intestinal health in broilers under necrotic enteritis (NE) challenge. A total 960 day-old mixed-sex Cobb 500 chicks were randomly distributed 48-floor pens with 6 treatments replicated 8 times 20...
This study was conducted to examine the effects of a plant extract mixture, microencapsulated product composed eugenol and garlic tincture (PE), on intestinal health in broilers under necrotic enteritis (NE) challenge. A total 960 d-old mixed-sex Cobb 500 chicks were randomly distributed 48-floor pens housing 20 birds per pen. Six treatments applied: UC, unchallenged control; CC, challenged PE, group plus PE; AM, antimicrobial (AM); FAP, full dose AM with HAP, half PE starter, grower...
In this work, for the first time, multi mineral complexes composed of three and four elements FeII, MnII, CuII & ZnII CuII, MnII ZnII, respectively) bounded to glycine have been produced be used as a feed additive farm animals. To best our knowledge, all products were synthesized time novel compounds containing several transition metals. The impact drying procedure on microstructure, chemical composition crystalline phase was evaluated using different analytical techniques. trace element...
1. This study examined the effects of different dietary sources and levels selenium (Se) on growth performance, hepatic breast meat Se content, glutathione peroxidase (GSH-Px) activity total antioxidant status (TAS) in blood, when fed to broilers from 14 35 d age reared at two temperatures (20°C 35°C). 2. Five hundred sixty male Ross 308 were a single floor pen same proprietary starter diet 0 (229.9 g/kg CP 12.67 MJ/kg ME, without supplementation). 3. The experiment started age, birds...
1. This study investigated the oxidative status of broilers fed diets containing selenium (Se) from 14 to 35 d age and reared at two different constant temperatures. Measurements included blood glutathione peroxidase (GSH-Px) plasma total antioxidant (TAS). Other variables feed intake (FI), weight gain (WG), conversion ratio (FCR), Se levels in breast liver tissue, jejunal villus morphometry, percentage organs relation body weight; apparent metabolisable energy adjusted for nitrogen (AMEn);...
Drug-resistant parasites threaten livestock production. Breeding more resistant hosts could be a sustainable control strategy. Environmental variation linked to animal management practices or parasite species turnover across farms may however alter the expression of genetic potential. We created sheep lines with high low resistance
Abstract Background Magnolia bark extract (MBE) is a natural supplement with antioxidant, anti-inflammatory, and antimicrobial activities. Its properties suggest that the dietary supplementation in livestock could improve quality of products. Therefore, aim this study was to investigate, for first time, effect MBE (0.33 mg/kg) finishing pigs on oxidative stability meat. Oxidative paramount importance pork, as it affects storage, retail, consumer acceptance. For purpose, fatty acid profile,...