A5056572870- Pancreatitis Pathology and Treatment
- Protein Degradation and Inhibitors
- Cancer-related gene regulation
- RNA modifications and cancer
- Chromatin Remodeling and Cancer
- T-cell and Retrovirus Studies
- Acute Lymphoblastic Leukemia research
- Alkaline Phosphatase Research Studies
- Pancreatic function and diabetes
- CAR-T cell therapy research
- Lysosomal Storage Disorders Research
- Chronic Lymphocytic Leukemia Research
- Chronic Myeloid Leukemia Treatments
- Abdominal vascular conditions and treatments
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Signaling Pathways in Disease
- Diabetes and associated disorders
- Immune Cell Function and Interaction
- Eosinophilic Disorders and Syndromes
- Calcium signaling and nucleotide metabolism
- Cell death mechanisms and regulation
- Pancreatic and Hepatic Oncology Research
- Electrostatic Discharge in Electronics
- PARP inhibition in cancer therapy
- Low-power high-performance VLSI design
Centro de Investigación Biomédica en Red de Cáncer
2020-2023
Hospital del Mar Research Institute
2020-2023
Hospital Del Mar
2021
Instituto de Investigación Biomédica de Salamanca
2015-2020
Universidad de Salamanca
2010-2020
Abstract Background Adult T cell acute lymphoblastic leukemia (T-ALL) is a rare disease that affects less than 10 individuals in one million. It has been studied its cognate pediatric malignancy, which more prevalent. A higher percentage of the adult patients relapse, compared to children. thus essential study mechanisms relapse T-ALL cases. Results We profile whole-genome somatic mutations 19 primary T-ALLs from and corresponding malignancies analyze their evolution upon treatment...
Chronic myeloid leukemia (CML) is characterized by the expression of oncogenic kinase BCR-ABL. Although tyrosine inhibitors (TKIs) against BCR-ABL represent standard therapeutic option for CML, resistances to TKIs can be a serious problem. Thus, search novel approaches still needed. CML cells show an increased ROS production, which required maintaining signaling cascade active. In line with that, reducing levels could interesting strategy clinical management resistant CML. To analyze...
The quantitative proteomics data reported here pertain to the research article entitled "A Tandem Mass Tag (TMT) proteomic analysis during early phase of experimental pancreatitis reveals new insights in disease pathogenesis" (García-Hernández et al., 2018) [1]. development acute (AP, an important pathological inflammatory state exocrine pancreas) would be based on changes protein expression and signaling pathways whose unmasking crucial for deciphering AP at molecular level. We a...
Abstract Activation of the IKK kinase complex has recurrently been linked to colorectal cancer (CRC) initiation and progression. However, identification downstream effectors other than NF-kB remained elusive. Analysis IKK-dependent substrates after UV-treatment revealed that BRD4 phosphorylation by IKKa is required for chromatin-binding dynamics upon damage. Moreover, induces NF-kB-dependent transcription LIF leading STAT3 activation, association recruitment specific target genes. abrogation...
SUMMARY Activation of the IKK kinase complex has recurrently been linked to colorectal cancer (CRC) initiation and progression. However, identification downstream effectors other than NF-κB remained elusive. Analysis IKK-dependent substrates after UV-treatment revealed that BRD4 phosphorylation by IKKα is required for chromatin-binding dynamics upon damage. Moreover, induces NF-κB-dependent transcription LIF leading STAT3 activation, association recruitment specific target genes. abrogation...
ABSTRACT Understanding the molecular mechanisms that contribute to appearance of chemotherapy resistant cell populations is necessary improve cancer treatment. We have now investigated role β-catenin/CTNNB1 in evolution T-Acute Lymphoblastic Leukemia (T-ALL) patients and its involvement therapy resistance. identified a specific gene signature directly regulated by β-catenin, TCF/LEF factors ZBTB33/Kaiso T-ALL lines, which highly significantly represented 5 out 6 refractory from cohort 40...
Abstract Activation of the IKK kinase complex has recurrently been linked to colorectal cancer (CRC) initiation and progression. However, identification downstream effectors other than NF-kB remained elusive. Analysis IKK-dependent substrates after UV-treatment revealed that BRD4 phosphorylation by IKKa is required for chromatin-binding dynamics upon damage. Moreover, induces NF-kB-dependent transcription LIF leading STAT3 activation, association recruitment specific target genes. abrogation...