A5088422814- Mosquito-borne diseases and control
- Viral Infections and Vectors
- Microtubule and mitosis dynamics
- Pregnancy and preeclampsia studies
- Dengue and Mosquito Control Research
- Hepatitis C virus research
- Surgical site infection prevention
- Malaria Research and Control
- Axon Guidance and Neuronal Signaling
- HIV/AIDS Research and Interventions
- Reproductive System and Pregnancy
- Protist diversity and phylogeny
- Apelin-related biomedical research
- Biocrusts and Microbial Ecology
- Congenital heart defects research
- Signaling Pathways in Disease
- Pregnancy and Medication Impact
- Soft tissue tumor case studies
- Slime Mold and Myxomycetes Research
- Neonatal skin health care
- Agriculture and Rural Development Research
- Health, Environment, Cognitive Aging
- Cardiac Fibrosis and Remodeling
- Urinary Tract Infections Management
- Blood disorders and treatments
Université Joseph Ki-Zerbo
2019-2024
University of Koudougou
2022
Inserm
2017-2020
Université de Bordeaux
2019-2020
Neurocentre Magendie
2017-2020
Centre National de la Recherche Scientifique
2014
Aix-Marseille Université
2014
Abstract Mutations in GPSM2 cause Chudley-McCullough syndrome (CMCS), an autosomal recessive neurological disorder characterized by early-onset sensorineural deafness and brain anomalies. Here, we show that mutation of the mouse orthologue affects actin-rich stereocilia elongation auditory vestibular hair cells, causing balance defects. The G-protein subunit Gα i3 , a well-documented partner Gpsm2, participates process, its absence also causes hearing deficits. We Gpsm2 defines ∼200 nm...
Dynamic mechanical interactions between adhesion complexes and the cytoskeleton are essential for axon outgrowth guidance. Whether planar cell polarity (PCP) proteins, which regulate dynamics appear necessary some guidance, also mediate with membrane is still unclear. Here we show that Vangl2 controls growth cone velocity by regulating internal retrograde actin flow in an N-cadherin-dependent fashion. Single molecule tracking experiments loss of decreased fast-diffusing N-cadherin molecules...
Accumulation of voltage‐gated sodium channel Nav1 at the axon initial segment (AIS), results from a direct interaction with ankyrin G. This is regulated in vitro by protein kinase CK2, which also highly enriched AIS. Here, using phosphospecific antibodies and inhibition/depletion approaches, we showed that channels are phosphorylated vivo their ankyrin‐binding motif. Moreover, observed CK2 accumulation AIS depends on expression channels, forms tight complexes. Thus, CK2–Nav1 likely to...
The human gastrointestinal tract exists as a complex ecosystem and contains mycobiome microbiome that play central roles in host health, disease immune system regulation. Here, we reviewed the traditional culture-dependent methods, culturomics methods molecular used to study gut microbiome. With development of next-generation sequencing techniques, these last two have greatly broadened understanding bacteria health disease. Thus, dysbiosis microbiota mycobiota has been found be associated...
In Chad, grilled meat has been well appreciated and consumed regularly. However, it could be the cause of many diseases if handled under unhygienic conditions. The objective this study was to evaluate microbiological quality antimicrobial resistance profile strains Salmonella spp. Escherichia coli isolated from in city N'Djamena. Thirty producers were surveyed at least once 02 August 2018 31 January 2019 one sample collected each them. Total Mesophile Aerobic Flora (TMAF), Thermotolerant...
Background: Urinary tract infections are still a real public health concern. The aim of this study was to identify the bacteria strains involved in urinary and determine their antibiotic resistance profiles. Methods: Two kinds studies were performed. retrospective carried out for 2 years (from January 2018 December 2019), prospective extended over period 6 months June 2020). Isolation identification performed using conventional microbiology techniques. strains’ profiles determined by...
L’émergence des bactéries multi-résistantes nécessite la recherche de biomolécules à activité antibactérienne. L’objectif du travail était d’isoler et caractériser souches d’actinomycètes productrices substances antimicrobiennes. Des échantillons sol ont été prélevés sur 2 sites : le parc urbain Bangré Weogo (BW) serre l’université Joseph KI-ZERBO. Les analysés au LaBIA, université KI-ZERBO (Burkina Faso). L’isolement a fait milieu Caséine-AmidonAgar supplémenté nystatine chloramphénicol...
Background The hormonal shift occurring in pregnant women is crucial for the outcome of pregnancy. We conducted a study living malaria endemic area to determine potential effect gestational age on modulation endocrine system by cortisol and prolactin production during Methods Primigravidae multigravidae with between 16–20 weeks were included followed up delivery 6–7 thereafter. Venous blood was collected at scheduled visit: Visit 1 (V1; amenorrhea), 2 (V2; 28 ±1 pregnancy), 3 (V3; 32 Visit4...
Malaria-endemic countries in Africa have recorded the lowest number of covid-19 cases and deaths compared to other countries. Pre-existing Naturally acquired Immunity malaria was an hypothesis that stated explain this situation. In a context where is endemic, we carried out study order investigate existence antibody cross-reactivity between COVID-19 estimate seroprevalence during third year pandemic plateau central Region Burkina Faso. Samples collected 2007 positive for IgG against...
Dengue fever is a mosquito-borne disease caused by four related but antigenically distinct dengue viruses. In the last half-century, prevalence of has increased dramatically (up to 30%) worldwide, especially in Sub-Saharan Africa. Burkina Faso, epidemic occurred 2016, and epidemiological situation still poorly documented at national level. Therefore, present study aimed conduct sentinel seroepidemiology suspected virus infections from 2017 2020 Charles de Gaulle University Pediatric Hospital...
<b>Background and Objective:</b> Dengue is a remerging vector-borne viral disease in Burkina Faso since the outbreak of 2013 requires special attention from health authorities. This study reports prevalence dengue fever serological markers (NS1Ag, IgM IgG) infection dynamic January, 2018 to December, 2020 among patients tested for at Saint Camille Hospital Ouagadougou (HOSCO). <b>Materials Methods:</b> The population consisted 6414 aged 0-97 years. virus was detected...
A higher number of ideal cardiovascular health (CVH) metrics is associated with a lower risk cardiovascular-related and all-cause mortality. However, the change in CVH has rarely been studied sub-Saharan Africa. We investigated level changes their correlates among Beninese adults between 2008 2015.
Surgical Site Infections (SSI) are caused in most cases by the resistant or multi-resistant bacteria. Gravities go from a simple superficial cutaneous infection to potentially deadly infections as stern septicemia. The objective of this survey is study antibiorésistance germs implied operative site General Hospital National Reference (HGRN) Ndjamena Chad . had taken place July November 2018. A total 51 Sites has been recorded then appropriated and sowed on Chapman, Mac Conkey, gélose...
In Human immunodeficiency virus infected (HIV+) patients, deregulation of regulatory T (Treg) cells can be deleterious for the development an efficient anti-HIV specific immune response with inappropriate activation despite anti-retroviral therapy (ART). addition, infection and ART have potential to cause hematological biochemical abnormalities that lead discontinuation ART. The aim this study was assess hematological, immunological in HIV+ patients’ naïve 6 months after initiation. a...
Abstract Background: The immunological shift occurring in pregnant women is crucial for the outcome of pregnancy. We conducted a study living malaria endemic area to determine potential effect gestational age on modulating immune system by cortisol and prolactin production. Methods: Primigravidae multigravidae with between 16-20 weeks were included followed up delivery 6-7 thereafter. Venous blood was collected at scheduled visit: Visit1 (V1; amenorrhea), Visit2 (V2; 28 ±1 pregnancy), Visit3...
The performance of specific antibodies in a post-chemotherapy situation remains controversial issue. Thus the study aims to investigate variations different immunoglobulins, IgG, IgG subclasses, IgM and IgA against Schistosoma mansoni soluble eggs antigens post-treatment their correlation with excretion. A longitudinal was conducted on 928 participants over 5 years age from February 2007 March 2008 “Vallee du Kou” Burkina Faso, rural area where S. is endemic. At inclusion during follow-up...
Knowledge of the clinical and biological profile patients infected with HIV hepatitis B and/or C is essential in order to identify implement effective management strategies. Methods: This was a retrospective descriptive study from January 01, 2016 June 2021. Adult aged at least 18 years type 1 2, na?ve ARV treatment. Univariate analyses were assessed using Pearson’s Chi2 test. The Student Newman test used for comparison between groups R software version 4.0.2. Objective: To draw up...
The risk to develop an infection after surgery depends on several factors. Those factors may be interdependent or not, depending the nature of and general condition patient. aim present study was identify involved in occurrence Surgical Site Infections (SSI) National referral hospital N’djamena (Chad). We first realized interview emergency services hospital. information collected allowed us draw up survey sheets. An investigation then conducted 152 patients who had were hospitalized during...
Toxoplasma gondii (T. gondii) infection can lead to abortion in pregnant women. Unfortunately, very limited information is available concerning the seroprevalence and associated risk factors women Burkina Faso. Therefore, present study aimed estimate of T. among attending for antenatal care. A cross-sectional was conducted containing 579 Ouagadougou, Serological patterns were assessed by enzyme-linked fluorescent immunoassay utilized univariate analysis identify potential infection. Of...