A5051701684- Forensic and Genetic Research
- Molecular Biology Techniques and Applications
- Pharmacogenetics and Drug Metabolism
- Race, Genetics, and Society
- Genetic diversity and population structure
- Forensic Anthropology and Bioarchaeology Studies
- Yersinia bacterium, plague, ectoparasites research
- Identification and Quantification in Food
- Bacillus and Francisella bacterial research
- Drug Transport and Resistance Mechanisms
- Rabies epidemiology and control
- Erythrocyte Function and Pathophysiology
- Genetic Associations and Epidemiology
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Blood groups and transfusion
- Forensic Entomology and Diptera Studies
- Fibroblast Growth Factor Research
- Environmental DNA in Biodiversity Studies
- Law, AI, and Intellectual Property
- Genetic Mapping and Diversity in Plants and Animals
- Chromosomal and Genetic Variations
- Genomics and Phylogenetic Studies
- Osteoarthritis Treatment and Mechanisms
- Cancer, Lipids, and Metabolism
- Ethics in Clinical Research
University of Bologna
2015-2024
Innovative technological approaches are crucial to enhance naturalistic museum collections and develop information repositories of relevant interest science, such as threatened animal taxa. In this context, museomics is an emerging discipline that provides a novel approach the enhancement exploitation these collections. present study, discovery neglected lion skeleton in Museum Zoology “Pietro Doderlein” University Palermo (Italy) offered opportunity undertake multidisciplinary project. The...
Abstract In this study, we report novel data on mitochondrial DNA in two of the largest eastern Bantu‐speaking populations, Shona from Zimbabwe and Hutu Rwanda. The goal is to evaluate genetic relationships these ethnic groups with other populations. Moreover, by comparing our those Niger‐Congo speaking aim clarify some aspects evolutionary demographic processes accompanying spread Bantu languages sub‐Saharan Africa test if patterns variation fit models population expansion based linguistic...
Rapidly Mutating Y-STRs (RM Y-STRs) were recently introduced in forensics order to increase the differentiation of Y-chromosomal profiles even case close relatives. We estimate RM mutation rates and their power discriminate between related individuals by using samples extracted from a wide set paternal pedigrees comparing results with those obtained Y-filer set. In addition, we tested ability unrelated carrying same haplotype, haplogroup R-M269 (reportedly characterised strong resemblance...
<i>Objectives:</i> The rarity of familial neuroblastoma (NB) has allowed only a few linkage studies, most which did not show any evidence to regions involved in somatic alterations or genes implicated other neurocristopathies seldom associated with NB. We screened highly informative family recurrent NB by genome-wide analysis aimed at identifying chromosomal for predisposing genes. <i>Methods:</i> A screen was performed using 382 microsatellite markers. Multipoint...
Abstract In the population genomics era, study of Y-chromosome variability is still greatest interest for several fields ranging from molecular anthropology to forensics and genetic genealogy. particular, mutation rates Y-chromosomal Short Tandem Repeats markers (Y-STRs) are key parameters different interdisciplinary applications. Among them, testing patrilineal relatedness between individuals calculating their Time Most Recent Common Ancestors (TMRCAs) utmost importance. To provide new...
Dog domestication is still largely unresolved due to time-gaps in the sampling of regions. Ancient Italian canids are particularly understudied, currently represented by only a few specimens. In present study, we sampled 27 canid remains from Northern Italy dated between Late Pleistocene and Bronze Age assess their genetic variability, thus add context dog dynamics. They were targeted at four DNA fragments hypervariable region 1 mitochondrial DNA. A total 11 samples had good preservation...
During osteoarthritis development, chondrocytes are subjected to a functional derangement. This increases their susceptibility stressful conditions such as oxidative stress, characteristic of the aging tissue, which can further provoke extrinsic senescence by DNA damage responses. It was previously observed that IκB kinase α knockdown replicative potential primary human OA cultured in monolayer and survival same cells undergoing hypertrophic-like differentiation 3-D. In this paper we...
In the last years, forensic research has been focused on touch DNA in order to improve its evidential value criminal activity investigations as well understand variables impacting DNA. One of emerging is represented by use alcohol-based sanitizers, which was suggested for hand hygiene during COVID-19 pandemic. The aims present study were assess effect a sanitizer deposition, transfer, and recovery also evaluate STR typing success, quality profiles, personal identification. Before after an...
Forensic DNA phenotyping (FDP) provides the ability to predict human external traits from unknown sample donors, directly minute amounts of found at crime scene. We developed a MPS multiplex assay, with aim genotyping all 41 markers included in HIrisPlex-S system for simultaneous prediction eye, hair and skin colours. samples such as blood, skeletal remains, touch DNA, saliva swab, artificially degraded together individuals known phenotypes set 2800 M control were sequenced on Ion Torrent...
Microsatellites or short tandem repeats (STRs) markers are important tools for mapping disease-causing genes by linkage, performing investigations in forensic medicine, population genetic studies and studying modifications tumors. In applications neoplastic tissues can be used as a source of information personal identification paternity testing when no other specimen is available. Cancer show microsatellite instability (MSI) loss heterozygosity (LOH) also the STRs field. this study, we...
Abstract Eritrea is a multi-ethnic country of over 3 million people consisting different ethnic groups, having each its own language and cultural tradition. Due to the lack population genetic data for markers forensic interest, in this study, we analyzed polymorphisms 23 Y-chromosome STR loci 12 X-chromosome sample 255 unrelated individuals from 8 Eritrean with aim generate reference haplotype database anthropological applications. X- Y-chromosomes may indeed offer information especially...
The relevance of the subfamily A members ATP-binding cassette (ABCA) transporters as biomarkers risk and response is emerging in different tumors, but their mechanisms action have only been partially defined. In this work, we investigated role Ewing sarcoma (EWS), a pediatric cancer with unmet clinical issues.The expression ABC was evaluated by RT-qPCR patients localized EWS. correlation outcome established datasets using univariate multivariate statistical methods. Functional studies were...
Background: Environmental conditions and past migratory events may have shaped genetic heterogeneity of clinically relevant enzymes involved in the phase I metabolism most common therapeutic drugs.Aim: To investigate variability CYP2D6, CYP2B6, CYP2C19 CYP2C9 across Italian Peninsula, by sampling only ancestrally geographically homogeneous individuals from northern, central southern Italy.Subjects methods: A total 25 SNPs were genotyped 174 unrelated means multiplex PCR minisequencing...