A5037920505- Pregnancy and preeclampsia studies
- Maternal and Perinatal Health Interventions
- Maternal and fetal healthcare
- Gestational Diabetes Research and Management
- Global Maternal and Child Health
- Birth, Development, and Health
- Prenatal Screening and Diagnostics
- Mosquito-borne diseases and control
- Reproductive Health and Contraception
- Preterm Birth and Chorioamnionitis
- Assisted Reproductive Technology and Twin Pregnancy
- Ectopic Pregnancy Diagnosis and Management
- Reproductive System and Pregnancy
- Pregnancy-related medical research
- Cardiovascular Issues in Pregnancy
- Neonatal Respiratory Health Research
- Blood Coagulation and Thrombosis Mechanisms
- Reproductive Health and Technologies
- Congenital Anomalies and Fetal Surgery
- Pelvic floor disorders treatments
- Bariatric Surgery and Outcomes
- Breastfeeding Practices and Influences
- Congenital Diaphragmatic Hernia Studies
- Global Health and Surgery
- Viral Infections and Vectors
Yale New Haven Hospital
2021-2024
Yale University
2018-2024
AmerisourceBergen (United States)
2024
Community Link
2023
Columbia University
2015-2021
NewYork–Presbyterian Hospital
2021
Columbia University Irving Medical Center
2015-2020
Texas Health Dallas
2020
Penn Presbyterian Medical Center
2020
Christiana Care Health System
2012-2015
Over 900 travel-associated Zika virus cases have been identified in New York City (NYC), York. A survey was administered NYC adapted from the Knowledge, Attitudes, and Practices (KAP) on developed by World Health Organization (WHO). standardized, self-administered, anonymous questionnaire to a convenience sample Manhattan Bronx June 30th, 2016 October 21st, 2016. Responses were grouped into six domains based content structure of questions summarized using descriptive statistics or converted...
Preeclampsia (PE), a hypertensive disorder of pregnancy, is leading cause maternal and fetal morbidity mortality. Although the etiology unknown, PE thought to be caused by defective implantation decidualization in pregnancy. Pregnant blood pressure high (BPH)/5 mice spontaneously develop placentopathies features human PE. We hypothesized that BPH/5 sites have transcriptomic alterations. Next-generation RNA sequencing at peak decidualization, embryonic day (E)7.5, revealed complement gene...
Objective: The objective of this study was to characterize risk for and temporal trends in postpartum hemorrhage across hospitals with different delivery volumes.Study design: This used the Nationwide Inpatient Sample (NIS) from 1998 2011. Hospitals were classified as having either low, moderate or high volume (≤1000, 1001 2000, >2000 deliveries per year, respectively). primary outcomes included hemorrhage, transfusion, related severe maternal morbidity. Adjusted models created assess...
In the first trimester of human pregnancy, low oxygen tension or hypoxia is essential for proper placentation and placenta function. Low levels activation signaling pathways have been implicated as critical mediators in promotion trophoblast differentiation, migration, invasion with inappropriate changes aberrant Notch both individually reported causative to abnormal placentation. Despite crosstalk between multiple cell types, relationship function not understood. To determine how a...
With the goal of identifying factors contributing to severe maternal morbidity (SMM) at our institution, we established a formal SMM review process. We performed retrospective cohort study including all cases as defined by American College Obstetricians and Gynecologists Society for Maternal-Fetal Medicine consensus criteria that were managed Yale-New Haven Hospital over 4-year period. Overall, 156 reviewed. The rate was 0.49% (95% CI 0.40-0.58). leading causes hemorrhage (44.9%)...
Breastfeeding is especially beneficial to women with diabetes and their infants, yet diabetic mothers frequently experience less favorable breastfeeding outcomes.
Objective This article evaluates trends in venous thromboembolism (VTE) prophylaxis during delivery hospitalizations the United States. Methods We utilized an administrative database to determine if women hospitalized for vaginal or cesarean received pharmacologic VTE prophylaxis, mechanical both from January 2011 through March 2015. Mechanical included sequential compression devices, graduated stockings, and other pneumatic devices. Pharmacologic unfractionated heparin, low molecular weight...
To clinically assess a cell-based noninvasive prenatal genetic test using sequence-based copy number analysis of single trophoblasts from maternal blood.
For every incidence of maternal mortality, morbidity is thought to occur in another 50 100 individuals the United States. Multiple risk factors for severe have been identified, but counseling about specific pregnancy remains difficult, particularly nulliparous as prior obstetric history one influencing morbidity. The objective this study examine association between sociodemographic and laboratory assessments first trimester nulliparas.
Objective Our primary objective was to compare the differential contribution of fetal number and maternal age risk hypertensive disorders pregnancy (HDP). Study Design This a secondary analysis large study cesarean delivery. Women with singleton, twin, or triplet gestations were included. divided into groups based on age. The outcome HDP. A logistic regression model fit adjust for confounders. incidence HDP compared reference group within exposure groups. Results Of 70,417 women included,...
INTRODUCTION: Activity restriction or “bed rest” is a commonly prescribed obstetric intervention, which lacks data demonstrating efficacy. Complications including bone demineralization, pulmonary atelectasis, venous thromboembolism, and muscle deconditioning have been attributed to bed rest. Exercise has known beneficial effect toward achieving good glycemic control in women with gestational diabetes mellitus (GDM). We sought quantitate the that rest on GDM. METHODS: performed retrospective...
Objective Our institution is in an area of New York City with a large population immigrants from Zika virus endemic areas. With the recent outbreak, we sought to examine our center's experience screening for and outcomes among patients who tested positive disease during pregnancy. Study Design We performed chart review all pregnant (positive serum or urine polymerase chain reaction [PCR]) presumed (immunoglobulin M [IgM] enzyme-linked immunosorbent assay [ELISA] IgM ELISA equivocal plaque...
To characterize use of uterine tamponade and interventional radiology procedures.
Objectives To determine whether isolated abnormal Doppler indices before 28 weeks predict adverse pregnancy outcomes in uncomplicated monochorionic diamniotic (MCDA) twins. Methods A retrospective cohort study of MCDA twin pregnancies receiving antenatal testing at a single center between 2007 and 2013 was conducted. Sonographic surveillance, including velocimetric studies the umbilical artery, ductus venosus, middle cerebral artery each twin, initiated by repeated least every 2 weeks. All...
The ability to diagnose preeclampsia clinically is suboptimal. Our objective was validate a novel multianalyte assay and characterize its performance, when intended for use as an aid rule-out preeclampsia.Prospective, multicenter cohort study of pregnant individuals presenting between 280/7 366/7 weeks' with preeclampsia-associated signs symptoms. Individuals not diagnosed after baseline evaluation were enrolled in the cohort, those who later developed preeclampsia, classified cases compared...
This study aimed to determine if one abnormal value of four on the diagnostic 3-hour oral glucose tolerance test (OGTT) is associated with adverse perinatal outcomes in obese women.This a secondary analysis prospective nulliparous women eight geographic regions. Women body mass index <30 kg/m2 and pregestational diabetes mellitus (GDM) were excluded. Four groups compared: (1) normal 50-g 1-hour screen, (2) elevated screen 100-g OGTT, (3) values (4) GDM. Using multivariable logistic...
The aim of this study was to investigate if gestational weight gain altered during the early COVID-19 pandemic period. This a retrospective cohort evaluating among individuals delivering epoch (March 10-December 31, 2020) compared temporally matched pre-pandemic (matched months in 2018 and 2019) controls using electronic medical record data from large tertiary care hospital. primary outcome defined as categorical measure representing below, meeting, or above Institute Medicine (IOM) criteria...
Prelabor rupture of the membranes (PROM) near limit viability is associated with significant risks for both mother and fetus. Preterm labor, intra-amniotic infection, placental abruption are immediate to pregnancy; however, fetus incurs additional related sequela persistent oligohydramnios. Transabdominal infusions have been studied. Results, suggesting that this intervention may prolong latency period, potentially, decrease pulmonary hypoplasia in surviving neonates without evidence...