Dynamic assessment of cardiac output (CO) with passive leg raise (PLR), stroke volume variation (SVV), and pulse pressure (PPV) offer effective safe methods to predict fluid responsiveness in patients shock. The primary aim this study was evaluate the reliability CO SVV readings Ultrasonic Cardiac Output Monitor (USCOM) 1A device compared PPV measurements determining Intubated mechanically ventilated aged 18-95 shock admitted medical intensive care unit from June 2019 December 2020 were...

High-flow nasal cannula therapy has been shown to be useful in the treatment of patients with acute respiratory failure caused by severe syndrome-coronavirus disease-2. The ROX index can help predict success high-flow coronavirus disease-19-related failure. However, timing ROX- assessment is still unclear protect from complications due early or delayed intubation.To evaluate relation between patterns within first 48 hours and rates. secondary aim was determine other possible predictors...

Activation of pancreatic stellate cells (PSCs) is a key event in fibrosis. Xanthine oxidase-derived free radicals are involved the mechanism chronic pancreatitis (CP). We here searched vivo effects allopurinol on PSC activation and its relation to tissue oxidative stress histological findings rat CP.Rat CP was induced with intraductal trinitrobenzene sulfonic acid groups 1 (n = 16) 2 10). Group 3 10) received saline. Four weeks after induction, group (200 mg/kg, s.c.), After 4 weeks,...

Sepsis is a state of augmented oxidative stress and diminished antioxidant capacity. High density lipoprotein (HDL) particles were shown to possess anti-inflammatory properties, as well Paraoxonase 1 (PON1), which an enzyme that also protective against HDL oxidation. Previous studies suggested possible role decreased PON1 activity or levels in sepsis patients.The present study was designed test hypothesis higher HDL-cholesterol could predict better survival patients.Observational...

Using Doppler echocardiography (DE), we measured pulmonary arterial systolic pressure (PASP) in rheumatoid arthritis (RA) patients without coexisting cardiopulmonary diseases. Accepting the normal upper limit of PASP as 30 mmHg, found elevated 11 out 40 (27.5%) RA patients, values being mostly 30–40 indicating mild hypertension (PHT). Although estimation by DE is not reliable cardiac catheterisation, it possible that elevations may contribute to high incidence cardiovascular events explained...

Based on the results of recent studies that reported depleted antioxidant capacity in patients with chronic pancreatitis (CP), prevention free radical production has gained importance antifibrotic treatment strategies CP. The aim this study was to investigate effects taurine oxidative and fibrosis experimental rat pancreatic fibrosis.CP induced male Sprague-Dawley rats by intraductal trinitrobenzene sulfonic acid (TNBS) dissolved ethanol. Taurine given intraperitoneally at a concentration...

Introduction: Our aim was to determine the effi cacy of trimetazidine on experimental sepsis rat model.Material and methods: Sixty rats were randomized into three groups.In Group 1, induced.In 2, induced as a therapeutic agent given.In 3, sham operated.Serum interleukin-1 beta (IL-1ß), tumor necrosis factor alfa (TNF-α), superoxide dismutase (SOD), glutathion peroxidase (GSH-Px) malondialdehyde (MDA) levels determined in all groups.Results: In serum GSH-Px SOD statistically signifi cantly...

Extracorporeal blood purification (EBP) therapies have shown promise as potential rescue treatments for patientswith septic shock. However, precise evidence regarding their effectiveness is lacking. This case-control study aimed to evaluate the 28-day survival benefit of a resin cartridge-based EBP therapy compared conventional in patients with shock.Materials and methods: The sample was collected retrospectively from medical records admitted intensivecare unit (ICU) between 2015 2020....

Hyperbaric oxygen (HBO) therapy has been shown to attenuate renal ischemia/reperfusion (I/R) injury in rats, when applied the early reperfusion period. The aim of this study was elucidate possible beneficial effects HBO on I/R injury, 24 h after ischemia. Rats were randomized into three groups: (1) control group (n = 20), (2) and (3) + 20). Renal created by interrupting blood flow for 30 min with a non-traumatic vascular clamp. administered continued 5 days. At end study, rats sacrificed...

Rhabdomyolysis ranges from an asymptomatic illness with elevated creatine kinase levels to a life-threatening condition associated extreme elevations in kinase, electrolyte imbalances, acute renal failure, and disseminated intravascular coagulation. The most common causes are crush injury, overexertion, alcohol abuse, certain medicines, toxic substances. A number of abnormalities endocrinopathies, including hypothyroidism, thyrotoxicosis, diabetic ketoacidosis, nonketotic hyperosmolar state,...

Treatment of severe hypercapnic respiratory failure (HRF) has some challenges in patients with chronic obstructive pulmonary disease (COPD) and acute distress syndrome (ARDS), especially when lung protective ventilation (LPV) strategies are required. Extracorporeal CO2 removal (ECCO2R) therapy is an emerging option to manage hypercapnia while allowing LPV these cases. However, further data on ECCO2R use still needed make clear recommendations.This study was conducted admitted intensive care...

Temporal arteritis is systemic vasculitis of medium and large sized vessels. The lowest incidence rates were reported in Turkey, Japan Israel. We aimed to investigate the results patients with biopsy-proven temporal those classified according American College Rheumatology criteria from a low-incidence region for arteritis. our study are noteworthy, since there limited data on pathologic diagnosis Turkey.We studied medical records, laboratory findings such as erythrocyte sedimentation rate...

Obesity has a significant effect on the cephalic spread of spinal block (SB) due to reduction in cerebrospinal fluid (CSF). SB is controlled by tissue blood flow addition CSF. Some positions and techniques surgery used can cause changes hemodynamics. We investigated effects hemodynamic that may occur during Transurethral prostate resection (TUR-P) lithotomy position (LP) at level obese versus nonobese individuals. Sixty patients who had undergone TUR-P operation under anesthesia were divided...

This study was designed to evaluate effects of hyperbaric oxygen (HBO) plus 3-aminobenzamide (3-AB) cotreatment on tissue oxidative stress parameters (TOSp), histopathology scores (THSc), and bacterial translocations (Bact-Trans) in an experimental model severe acute pancreatitis (AP).Seventy-five Sprague-Dawley rats were randomized into 5 groups. Group 1 received sham. Severe AP induced by intraductal taurocholate infusion then group 2 saline, 3 3-AB, 4 3-AB HBO, HBO. 3-Aminobenzamide (10...

The aim of this study was to evaluate the effects N-acetylcysteine (NAC) and desferoxamine (DFO) administered alone or in combination together rats with doxorubicin (DOX)-induced nephrotic syndrome, by monitoring oxidative stress parameters trace elements renal tissue erythrocytes. Fifty-four male Sprague-Dawley were included study. Equal volume isotonic saline injected control rats. After DOX administration, animals divided into four experimental groups: (a) given only DOX; (b) treated NAC;...