Robert T. Koch
A5052687184- SARS-CoV-2 and COVID-19 Research
- SARS-CoV-2 detection and testing
- Viral Infections and Vectors
- Mosquito-borne diseases and control
- Viral gastroenteritis research and epidemiology
- Malaria Research and Control
- Animal Virus Infections Studies
- Vector-borne infectious diseases
- Vibrio bacteria research studies
- Syphilis Diagnosis and Treatment
- COVID-19 Impact on Reproduction
- COVID-19 Clinical Research Studies
- Bacillus and Francisella bacterial research
- Advanced biosensing and bioanalysis techniques
- COVID-19 epidemiological studies
- Biosensors and Analytical Detection
Yale University
2021-2024
The SARS-CoV-2 Delta variant rose to dominance in mid-2021, likely propelled by an estimated 40%–80% increased transmissibility over Alpha. To investigate if this ostensible difference is uniform across populations, we partner with public health programs from all six states New England the United States. We compare logistic growth rates during each variant's respective emergence period, finding that emerged 1.37–2.63 times faster than Alpha (range states). compute variant-specific effective...
Abstract Dengue is the most prevalent mosquito-borne viral disease in humans, and cases are continuing to rise globally. In particular, islands Caribbean have experienced more frequent outbreaks, all four dengue virus (DENV) serotypes been reported region, leading hyperendemicity increased rates of severe disease. However, there significant variability regarding surveillance reporting between islands, making it difficult obtain an accurate understanding epidemiological patterns Caribbean. To...
Abstract The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Delta variant quickly rose to dominance in mid-2021, displacing other variants, including Alpha. Studies using data from the United Kingdom and India estimated that was 40-80% more transmissible than Alpha, allowing become globally dominant variant. However, it unclear if ostensible difference relative transmissibility due mostly innate properties of Delta’s infectiousness or differences study populations. To...
Abstract The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants continues to shape the disease 2019 (Covid-19) pandemic. detection and rapid spread SARS-CoV-2 ‘ Omicron’ variant (lineage B.1.1.529) in Botswana South Africa became a global concern because it contained 15 mutations spike protein immunogenic receptor binding domain was less neutralized by sera derived from vaccinees compared previously dominant Delta variant. To investigate if Omicron is more...
Abstract Dengue is the most prevalent mosquito-borne viral disease in humans, and cases are continuing to rise globally. In particular, islands Caribbean have experienced more frequent outbreaks, all four dengue virus (DENV) serotypes been reported region, leading hyperendemicity increased rates of severe disease. However, there significant variability regarding surveillance reporting between islands, making it difficult obtain an accurate understanding epidemiological patterns Caribbean. To...
Mutations in the genome of SARS-CoV-2 can affect performance molecular diagnostic assays. In some cases, such as S-gene target failure, impact serve a unique indicator particular variant and provide method for rapid detection.
Abstract Diverse mammalian species display susceptibility to SARS-CoV-2. Potential SARS-CoV-2 spillback into rodents is understudied despite their host role for numerous zoonoses and human proximity. We assessed exposure infection among white-footed mice ( Peromyscus leucopus ) in Connecticut, USA. observed 1% (6/540) wild-type neutralizing antibody seroprevalence 2020–2022 residential with no cross-neutralization of variants. detected infections via RT-qPCR, but identified non-SARS-CoV-2...
Pooled testing for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) detection is instrumental increasing test capacity while decreasing cost. programs permit sustainable, long-term surveillance measures, which are essential the early of virus resurgence in communities or emergence variants concern. While numerous pooled approaches have been proposed to increase capacity, uptake by laboratories has limited. On 9 December 2020, we invited 362 U.S. that inquired about Yale School...
Abstract Eastern equine encephalitis virus (EEEV) causes a rare but severe disease in horses and humans, is maintained an enzootic transmission cycle between songbirds Culiseta melanura mosquitoes. In 2019, the largest EEEV outbreak United States for more than 50 years occurred, centered Northeast. To explore dynamics of outbreak, we sequenced 80 isolates combined them with existing genomic data. We found that, like previous years, cases were driven by frequent short-lived introductions into...
Abstract Diverse mammalian species display susceptibility to and infection with SARS-CoV-2. Potential SARS-CoV-2 spillback into rodents is understudied despite their host role for numerous zoonoses human proximity. We assessed exposure among white-footed mice ( Peromyscus leucopus ) in Connecticut, USA. observed 1% (6/540) wild-type neutralizing antibody seroprevalence 2020-2022 residential no cross-neutralization of variants. detected infections via RT-qPCR, but identified non-SARS-CoV-2...
Mutations in the viral genome of SARS-CoV-2 can impact performance molecular diagnostic assays. In some cases, such as S gene target failure, serve a unique indicator particular variant and provide method for rapid detection. Here we describe partial ORF1ab failure (pOGTF) on cobas ® assays, defined by ≥2 thermocycles delay detection compared to E gene. We demonstrate that pOGTF is 97% sensitive 99% specific lineage BA.2.12.1, an emerging United States with spike L452Q S704L mutations may...