A5037867236- Mosquito-borne diseases and control
- Malaria Research and Control
- Parasites and Host Interactions
- Vector-borne infectious diseases
- Parasite Biology and Host Interactions
- Primate Behavior and Ecology
- Insect Pest Control Strategies
- COVID-19 epidemiological studies
- Vibrio bacteria research studies
- Agriculture and Rural Development Research
- Insect-Plant Interactions and Control
- Insect symbiosis and bacterial influences
- Complement system in diseases
- Child Nutrition and Water Access
- Influenza Virus Research Studies
- Fish biology, ecology, and behavior
- Yersinia bacterium, plague, ectoparasites research
- Climate Change and Health Impacts
- Bacterial Identification and Susceptibility Testing
- Hemoglobinopathies and Related Disorders
- Streptococcal Infections and Treatments
- Travel-related health issues
- Invertebrate Immune Response Mechanisms
- Fish Biology and Ecology Studies
- Global Maternal and Child Health
Universidad Peruana Cayetano Heredia
2014-2025
Instituto de Medicina Tropical
2020
University of California, San Francisco
2015
University at Albany, State University of New York
2014
New York State Department of Health
2014
Wadsworth Center
2014
Universidad Nacional de la Amazonía Peruana
2011
Malaria transmission requires that Anopheles mosquitoes ingest Plasmodium gametocyte stages circulating in the human bloodstream. In context of malaria elimination, understanding epidemiology gametocytes relative to all infections and contribution asymptomatic sub-microscopic parasite carriers reservoir is necessary, especially low endemic settings with predominance P.vivax. A 13-month longitudinal study was conducted two communities (n = 1935 individuals) Loreto Department, Peru, five...
Anopheles darlingi Root is the most important malaria vector in Amazonia region of South America. However, continuous propagation An. laboratory has been elusive, limiting entomological, genetic/genomic, and vector–pathogen interaction studies this mosquito species. Here, we report establishment an colony derived from wild-caught mosquitoes obtained northeastern Peruvian Amazon Iquitos Loreto Department. We show that numbers eggs, larvae, pupae, adults continue to rise at least F6...
Understanding the epidemiological features and metrics of malaria in endemic populations is a key component to monitoring quantifying impact current past control efforts inform future ones. The International Centers Excellence for Malaria Research (ICEMR) has opportunity evaluate interventions across regions that differ dominant Plasmodium species, mosquito vector resistance antimalarial drugs human genetic variants thought confer protection from infection clinical manifestations plasmodia...
Malaria remains an important public health problem in Peru where incidence has been increasing since 2011. Of over 55,000 cases reported 2017, Plasmodium vivax was the predominant species (76%), with P. falciparum responsible for remaining 24%. Nyssorhynchus darlingi (previously Anopheles darlingi) is main vector Amazonian Peru, hyperendemic transmission pockets have found. Mazán district pronounced spatial heterogeneity of malaria. However, little known about behavior, ecology or seasonal...
Background While the global burden of malaria cases has decreased over last two decades, disease remains a major international threat, even on rise in many regions. More than 85% Peruvian are Amazonian region Loreto. Internal mobility primarily related to occupation is thought be responsible for maintaining endemicity and introducing reintroducing parasites into areas anophelism, challenge eradication. This study focuses identifying sources transmission patterns human order understand...
Understanding the dynamics of malaria transmission in diverse endemic settings is key for designing and implementing locally adapted sustainable control elimination strategies. A parasitological epidemiological survey was conducted September–October 2012, as a baseline underlying 3-year population-based longitudinal cohort study. The aim to characterize patterns two contrasting ecological rural sites Peruvian Amazon, Lupuna (LUP), riverine environment, Cahuide (CAH), associated with...
Background Antibody responses as serological markers of Plasmodium vivax infection have been shown to correlate with exposure, but little is known about the other factors that affect antibody in naturally infected people from endemic settings. To address this question, we studied IgG novel exposure (SEMs) P . three settings different transmission intensity. Methodology We validated a panel 34 SEMs Peruvian cohort up years’ longitudinal follow-up using multiplex platform and compared results...
Background The landscape of malaria transmission in the Peruvian Amazon is temporally and spatially heterogeneous, presenting different micro-geographies with particular epidemiologies. Most cases are asymptomatic escape routine surveillance based on light microscopy (LM). Following implementation control programs this region, new approaches to stratify direct efforts at an individual community level needed. Antibody responses serological exposure markers (SEM) Plasmodium vivax have proven...
In Amazonian Peru, the primary malaria vector, Nyssorhynchus darlingi (formerly Anopheles darlingi), is difficult to target using standard vector control methods because it mainly feeds and rests outdoors. Larval source management could be a useful supplementary intervention, but determine its feasibility, more detailed studies on larval ecology of Ny. are essential. We conducted multi-level study Anophelinae mosquitoes in peri-Iquitos region examining environmental characteristics habitats...
Despite efforts made over decades by the Peruvian government to eliminate malaria, Plasmodium vivax remains a challenge for public health decision-makers in country. The uneven distribution of its incidence, plus complex pattern dispersion, has ineffective control measures based on global information that lack necessary detail understand transmission fully. In this sense, population genetic tools can complement current surveillance. This study describes diversity and structure from September...
The measurement of recent malaria exposure can support control efforts. This study evaluated serological responses to an in-house Plasmodium vivax Merozoite Surface Protein 8 (PvMSP8) expressed in a Baculovirus system as sero-marker P. (Pv) the Peruvian Amazon. In first evaluation, IgGs against PvMSP8 and PvMSP10 proteins were measured by Luminex cohort 422 Amazonian individuals with known history Pv (monthly data infection status qPCR and/or microscopy over five months). Both able...
Objetivos. Evaluar la posesión, retención y uso de mosquiteros tratados con insecticida larga duración (MTILD) luego un año su distribución en Loreto, Perú. Materiales métodos. De julio a septiembre 2007 se distribuyeron 26 185 MTILD Olyset Net® 194 comunidades objetivo que protegieron 45 331 personas. Posteriormente, realizaron visitas monitoreo (primera diciembre segunda 2008) los hogares una muestra 60 (30,9% del total), colectándose mediante cuestionario semiestructurado datos necesarios...
Understanding the reservoir and infectivity of Plasmodium gametocytes to vector mosquitoes is crucial align strategies aimed at malaria transmission elimination. Yet, experimental information scarce regarding vivax for in diverse epidemiological settings where proportion asymptomatically infected individuals varies a microgeographic scale. We measured transmissibility clinical subclinical P. parasite carriers major mosquito Amazon Basin, Nyssorhynchus darlingi (formerly Anopheles). A total...
Malaria is highly heterogeneous: its changing malaria microepidemiology needs to be addressed support elimination efforts at the regional level.A 3-year, population-based cohort study in 2 settings Peruvian Amazon (Lupuna, Cahuide) followed participants by passive and active case detection from January 2013 December 2015. Incidence prevalence rates were estimated using microscopy polymerase chain reaction (PCR).Lupuna registered 1828 infections (1708 Plasmodium vivax, 120 falciparum;...
A transmission-blocking vaccine (TBV) to prevent malaria-infected humans from infecting mosquitoes has been increasingly considered as a tool for malaria control and elimination. This study tested the hypothesis that TBV would be acceptable among residents of malaria-hypoendemic region. The was carried out in six Spanish-speaking rural villages Department Loreto Peruvian Amazon. These comprise cohort 430 households associated with Peru-Brazil International Centre Excellence Malaria Research....
Abstract Background While the global burden of malaria cases has decreased over last two decades, disease remains a major international threat, even on rise in many regions. More than 85% Peruvian are Amazonian region Loreto. Internal mobility primarily related to occupation is thought be responsible for maintaining endemicity and introducing reintroducing parasites into areas anophelism, challenge eradication. Methods The assessment connectivity produced by human was evaluated three...
In the Peruvian Amazon, Plasmodium vivax malaria transmission is maintained due to high frequency of recurrences. By understanding recurrence rates submicroscopic and asymptomatic cases, we can develop informed strategies prevent more efficiently disrupt silent cycle.
Herein, we tested the hypothesis that Asymptomatic P. vivax (Pv) infected individuals (Asym) feature different epidemiological, clinical and biochemical characteristics, as well hematological parameters, potentially predictive of immunity in comparison to symptomatic Pv (Sym). Between 2018 - 2021, conducted 11 population screenings (PS, Day 0 (D0)) 13 riverine communities around Iquitos city, Peruvian Amazon, identify Sym Asym individuals. A group these agreed participate a nested case...
Objectives. To assess long-lasting insecticide - treated bednet (LLITN) ownership, retention and usage one year after their distribution in Loreto, Peru. Materials methods. from July to September 2007, 26,185 LLITNs Olyset Net ® were delivered 194 targeted communities the Peruvian Amazon region, covering 45,331 people. Two cross-sectional community-based surveys December 2007 2008 undertaken a sample of 60 (30.9% out total). A semi-structured questionnaire was used collect necessary data...
Abstract Background Antibody responses as serological markers of Plasmodium vivax infection have been shown to correlate with exposure, but little is known about the other factors that affect antibody in naturally infected people from endemic settings. To address this question, we studied IgG novel exposure (SEMs) P. three settings different transmission intensity. Methodology We validated a panel 34 SEMs Peruvian cohort up years’ longitudinal follow-up using multiplex platform and compared...
Background: Strategies that respond to highly heterogeneous and changing local malaria micro-epidemiology are needed support control programs in countries with goals move from low zero transmission. Using a population-based cohort design, we assessed the temporal spatial dynamics of transmission two contrasting epidemiological settings Peruvian Amazon, riverine Lupuna (LUP) deforested, road-associated Cahuide (CAH). Methods: After census baseline survey, 1,988 enrolled participants (LUP:...