A5046892931- Malaria Research and Control
- Mosquito-borne diseases and control
- Microbial infections and disease research
- Natural Products and Biological Research
- Lipid metabolism and biosynthesis
- Random Matrices and Applications
- Vector-borne infectious diseases
- Venomous Animal Envenomation and Studies
- Parasitic Infections and Diagnostics
- Point processes and geometric inequalities
- Digital Imaging for Blood Diseases
- Advanced Algebra and Geometry
- Mycobacterium research and diagnosis
- Stochastic processes and statistical mechanics
- Mediterranean and Iberian flora and fauna
- Invertebrate Immune Response Mechanisms
- Genomics and Phylogenetic Studies
- Parasite Biology and Host Interactions
- Aquaculture disease management and microbiota
- Oil Palm Production and Sustainability
- Parasites and Host Interactions
- Hemoglobinopathies and Related Disorders
- Biosensors and Analytical Detection
- Genetic diversity and population structure
- Bird parasitology and diseases
Harvard University
2024-2025
Broad Institute
2024
Universidad Peruana Cayetano Heredia
2015-2021
Malaria in Peru, dominated by Plasmodium vivax, remains a public health problem. The 1990s saw newly epidemic malaria emerge, primarily the Loreto Department Amazon region, including areas near to Iquitos, capital city, but sporadic transmission also occurred 1990s–2000s both north-coastal Peru and gold mining regions of southeastern Peru. Although Global Fund-supported intervention (PAMAFRO, 2005–2010) was temporally associated with decrease transmission, from 2012 present, P. vivax...
<title>Abstract</title> Background Outside of sub-Saharan Africa, <italic>Plasmodium vivax</italic> has become the dominant species malaria. Focal mass drug administration (fMDA) is a potential strategy to support elimination efforts, but controlled studies are lacking. Methods The FocaL Administration for Malaria Elimination (FLAME) study 3-year cluster randomized trial determine impact and safety fMDA reduce <italic>P. transmission. will be conducted in Loreto, Peru, where standard...
Understanding the dynamics of malaria transmission in diverse endemic settings is key for designing and implementing locally adapted sustainable control elimination strategies. A parasitological epidemiological survey was conducted September–October 2012, as a baseline underlying 3-year population-based longitudinal cohort study. The aim to characterize patterns two contrasting ecological rural sites Peruvian Amazon, Lupuna (LUP), riverine environment, Cahuide (CAH), associated with...
Loop-mediated isothermal DNA amplification (LAMP) methodology offers an opportunity for point-of-care (POC) molecular detection of asymptomatic malaria infections. However, there is still little evidence on the feasibility implementing this technique population screenings in isolated field settings.Overall, we recruited 1167 individuals from terrestrial ('road') and hydric ('riverine') communities Peruvian Amazon a cross-sectional survey to detect The technical performance LAMP was evaluated...
Despite efforts made over decades by the Peruvian government to eliminate malaria, Plasmodium vivax remains a challenge for public health decision-makers in country. The uneven distribution of its incidence, plus complex pattern dispersion, has ineffective control measures based on global information that lack necessary detail understand transmission fully. In this sense, population genetic tools can complement current surveillance. This study describes diversity and structure from September...
The measurement of recent malaria exposure can support control efforts. This study evaluated serological responses to an in-house Plasmodium vivax Merozoite Surface Protein 8 (PvMSP8) expressed in a Baculovirus system as sero-marker P. (Pv) the Peruvian Amazon. In first evaluation, IgGs against PvMSP8 and PvMSP10 proteins were measured by Luminex cohort 422 Amazonian individuals with known history Pv (monthly data infection status qPCR and/or microscopy over five months). Both able...
Malaria is highly heterogeneous: its changing malaria microepidemiology needs to be addressed support elimination efforts at the regional level.A 3-year, population-based cohort study in 2 settings Peruvian Amazon (Lupuna, Cahuide) followed participants by passive and active case detection from January 2013 December 2015. Incidence prevalence rates were estimated using microscopy polymerase chain reaction (PCR).Lupuna registered 1828 infections (1708 Plasmodium vivax, 120 falciparum;...
Several platforms have been used to generate the primary data for microsatellite analysis of malaria parasite genotypes. Each has relative advantages but share a limitation being time- and cost-intensive. A commercially available automated capillary gel cartridge system was assessed in Plasmodium vivax diversity Peruvian Amazon.The reproducibility accuracy commercially-available system, QIAxcel, using sequenced PCR product 227 base pairs. This measured 42 times, then 27 P. samples from...
<title>Abstract</title> The elimination of <italic>Plasmodium vivax</italic> is challenged by dormant liver stages (hypnozoites) that can reactivate months after initial infection resulting in relapses enhance transmission. Relapsing infections confound antimalarial clinical efficacy trials due to the inability distinguish between recurrences arising from blood-stage treatment failure (recrudescence), reinfection or relapse. Genetic relatedness paired parasite isolates, measured...
Abstract The elimination of Plasmodium vivax is challenged by dormant liver stages (hypnozoites) that can reactivate months after initial infection resulting in relapses enhance transmission. Relapsing infections confound antimalarial clinical efficacy trials due to the inability distinguish between recurrences arising from blood-stage treatment failure (recrudescence), reinfection or relapse. Genetic relatedness paired parasite isolates, measured identity-by-descent (IBD), provide important...
In this manuscript we give an extension of the classic Salem--Zygmund inequality for locally sub-Gaussian random variables. As application, concentration roots a Kac polynomial is studied, which main contribution manuscript. More precisely, assume existence moment generating function iid coefficients and prove that there exists annulus width \[O(n^{-2}(\log n)^{-1/2-γ}), \quad γ>1/2\] around unit circle does not contain with high probability. another show smallest singular value circulant...
The African oil palm ( Elaeis guineensis Jacq) is a crop that widely distributed in tropical regions around the world; however, this subject to limitations such as rapid trunk growth and susceptibility bud rot red ring diseases particularly South America. To overcome these limitations, national breeding conservation programs have been established, there need identify parental palms from natural populations of American E . oleifera H.B.K. Cortes) with desirable yield morphological traits...
We prove the universal asymptotically almost sure non-singularity of general Ginibre and Wigner ensembles random matrices when distribution entries are independent but not necessarily identically distributed may depend on size matrix. These models include adjacency graphs also sparse, generalized, banded matrices. find rates convergence precise estimates for probability singularity which only biggest jump functions governing matrix range values entries. Moreover, no moment assumptions made...
Background: Strategies that respond to highly heterogeneous and changing local malaria micro-epidemiology are needed support control programs in countries with goals move from low zero transmission. Using a population-based cohort design, we assessed the temporal spatial dynamics of transmission two contrasting epidemiological settings Peruvian Amazon, riverine Lupuna (LUP) deforested, road-associated Cahuide (CAH). Methods: After census baseline survey, 1,988 enrolled participants (LUP:...