A5019110707- Mosquito-borne diseases and control
- Malaria Research and Control
- Liver Disease Diagnosis and Treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Hepatitis B Virus Studies
- Parasite Biology and Host Interactions
- Global Maternal and Child Health
- Parasites and Host Interactions
- Vector-borne infectious diseases
- Forensic and Genetic Research
- Insect symbiosis and bacterial influences
- Biosensors and Analytical Detection
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Epigenetics and DNA Methylation
- Ethics in Clinical Research
- Genomics and Rare Diseases
- Genetic diversity and population structure
- Digital Imaging for Blood Diseases
- Fish biology, ecology, and behavior
- Cancer, Lipids, and Metabolism
- Hemoglobinopathies and Related Disorders
- Bird parasitology and diseases
- Health Systems, Economic Evaluations, Quality of Life
- Pancreatic and Hepatic Oncology Research
- Travel-related health issues
Pharmacochimie et Pharmacologie pour le Développement
2025
Instituto Nacional de Enfermedades Neoplásicas
2023-2025
Université Toulouse III - Paul Sabatier
2025
Institut de Recherche pour le Développement
2025
Université de Toulouse
2025
Universidad Peruana Cayetano Heredia
2013-2024
International Potato Center
2022-2024
Instituto de Medicina Tropical
2015-2020
Background Characterizing the parasite dynamics and population structure provides useful information to understand dynamic of transmission better target control interventions. Despite considerable efforts for its control, vivax malaria remains a major health problem in Peru. In this study, we have explored genetics Plasmodium isolates from Iquitos, main city Peruvian Amazon, 25 neighbouring peri-urban as well rural villages along Iquitos-Nauta Road. Methodology/ Results From April December...
Abstract Malaria has steadily increased in the Peruvian Amazon over last five years. This study aimed to determine parasite prevalence and micro-geographical heterogeneity of Plasmodium vivax parasitaemia communities Amazon. Four cross-sectional active case detection surveys were conducted between May July 2015 four riverine Mazan district. Analysis 2785 samples 820 individuals nested within 154 households for was carried out using light microscopy qPCR. The spatio-temporal distribution...
Malaria transmission requires that Anopheles mosquitoes ingest Plasmodium gametocyte stages circulating in the human bloodstream. In context of malaria elimination, understanding epidemiology gametocytes relative to all infections and contribution asymptomatic sub-microscopic parasite carriers reservoir is necessary, especially low endemic settings with predominance P.vivax. A 13-month longitudinal study was conducted two communities (n = 1935 individuals) Loreto Department, Peru, five...
Background With low and markedly seasonal malaria transmission, increasingly sensitive tools for better stratifying the risk of infection targeting control interventions are needed. A cross-sectional survey to characterize current transmission patterns, identify hotspots, detect recent changes using parasitological serological measures was conducted in three sites Peruvian Amazon. Material Methods After full census study population, 651 participants were interviewed, clinically examined had...
Peru has presented a decreasing malaria trend during the last decade, particularly in areas on northwestern coast; however, limited number of cases continues to be reported yearly mainly hotspots.A two-phase study was conducted identify spatial and temporal clusters incident Plasmodium vivax malaria, as well determine risk factors associated with households (HH) presenting P. episodes an urban area Peruvian Coast from June 2008 May 2010. In first stage, full census population conducted,...
This article highlights Peru's experience in establishing a national tumor bank network, serving as model for low- and middle-income countries. Launched 2005 at the National Institute of Neoplastic Diseases, efforts accelerated under 2021 Cancer Act, which formalized Tumor Bank its integration with Oncology Network. initiative connects banks across regional cancer institutes, enabling systematic biological sample collection, particularly from underrepresented populations, such those high...
ABSTRACT In the last three decades, DNA sequencing of ancient animal osteological assemblages has become an important tool complementing standard archaeozoological approaches to reconstruct history domestication. However, key archaeological contexts are not always available or do necessarily preserve enough for a cost‐effective genetic analysis. Here, we develop in‐solution target‐enrichment approach, based on 80‐mer species‐specific RNA probes (ranging from 306 1686 per species)...
Where malaria endemicity is low, control programmes need increasingly sensitive tools for monitoring transmission intensity (MTI) and to better define health priorities. A cross-sectional survey was conducted in a low area of the Peruvian north-western coast assess MTI using both molecular serological tools.Epidemiological, parasitological data were collected from 2,667 individuals three settlements Bellavista district, May 2010. Parasite infection detected microscopy polymerase chain...
Loop-mediated isothermal DNA amplification (LAMP) methodology offers an opportunity for point-of-care (POC) molecular detection of asymptomatic malaria infections. However, there is still little evidence on the feasibility implementing this technique population screenings in isolated field settings.Overall, we recruited 1167 individuals from terrestrial ('road') and hydric ('riverine') communities Peruvian Amazon a cross-sectional survey to detect The technical performance LAMP was evaluated...
Background: Faced with the resurgence of malaria, malaria surveillance in Peruvian Amazon incorporated consecutive active case detection (ACD) interventions using light microscopy (LM) as reactive measure communities an unusual high number cases during transmission season (HTS). We assessed effectiveness this local ACD-based strategy. Methods: A cohort study was conducted June⁻July 2015 Mazan, Loreto. Four ACD at intervals 10 days were four riverine (Gamitanacocha, Primero de Enero, Libertad...
Abstract Background Case management is one of the principal strategies for malaria control. This study aimed to estimate economic costs uncomplicated case and explore influence health-seeking behaviours on those costs. Methods A knowledge, attitudes practices (KAP) survey was applied 680 households fifteen communities in Mazan-Loreto March 2017, then a socio-economic conducted September 2017 among 161 individuals with confirmed past 3 months. Total per episode were estimated from both...
Remote rural riverine villages account for most of the reported malaria cases in Peruvian Amazon. As transmission decreases due to intensive standard control efforts, strategies these will need be more focused and adapted local epidemiology.By integrating parasitological, entomological, environmental observations between January 2016 June 2017, we provided an in-depth characterization dynamics 4 Mazan district, Loreto department.Despite variation across villages, prevalence by polymerase...
Plasmodium vivax is co-endemic with falciparum in Peru, and optimum management requires distinguishing these two species the blood of patients. For differential identification P. other spp., LoopampTM Malaria Pan Detection Kit combination Loopamp Pv (Eiken Chemical Co. Ltd., Tokyo, Japan) was used to evaluate 559 whole samples collected 2017 from febrile patients suspected malaria attending different health facilities Loreto region. The showed a sensitivity 87.7% (95% CI: 83.5-91.9)...
<h2>Abstract</h2> Malaria continues to wreak havoc in the Peruvian Amazon. Lengthy research efforts have brought important lessons on its particular epidemiology: heterogeneous levels of transmission, large reservoir both asymptomatic and submicroscopic infections, co-transmission <i>Plasmodium vivax</i> falciparum</i> same areas, limitations current diagnostics. Based these features, national elimination program could greatly benefit from simplified standard treatment, with use...
En Perú, el carcinoma hepatocelular (CHC) ocupa tercer lugar en incidencia entre los tumores del sistema digestivo, y tiene una alta tasa de mortalidad, 17.7 por 100,000 habitantes. La mayoría casos reportados no presentan la epidemiología clínica clásica CHC observado otras partes mundo. Además, se ha identificado que estos pacientes un perfil transcriptómico distinto proceso tumoral singular, sugiriendo particular hepatocarcinogénesis fracción población peruana. El presente estudio busca...
Hepatocellular carcinoma (HCC) is the third most frequent cancer of digestive tract tumors in Peru, with a high mortality rate 17.7 per 100,000 inhabitants. A significant number HCC cases Peru do not follow classic clinical epidemiology disease described other parts world. Those patients present distinct transcriptome profile and singular tumor process, suggesting particular type hepatocarcinogenesis portion Peruvian population. Our aim was to understand biologic involvement epigenetic...