A5011951514- Visual perception and processing mechanisms
- Neural and Behavioral Psychology Studies
- Neural dynamics and brain function
- COVID-19 Clinical Research Studies
- Genomics and Rare Diseases
- Chronic Disease Management Strategies
- COVID-19 and healthcare impacts
- Global Cancer Incidence and Screening
- Machine Learning in Healthcare
- Genetic Associations and Epidemiology
- Biomedical Text Mining and Ontologies
- EEG and Brain-Computer Interfaces
- Gender and Feminist Studies
- Head and Neck Cancer Studies
- Medical Coding and Health Information
- Color perception and design
- Bioinformatics and Genomic Networks
- Language, Metaphor, and Cognition
- Climate Change and Health Impacts
- Remote-Sensing Image Classification
- Face Recognition and Perception
- Peptidase Inhibition and Analysis
- Autoimmune Bullous Skin Diseases
- Geriatric Care and Nursing Homes
- Healthcare Systems and Technology
University College London
2010-2025
Health Data Research UK
2020-2022
Universidad Autónoma de Madrid
2006-2010
University of Illinois Urbana-Champaign
2008-2010
BackgroundThe medical, societal, and economic impact of the coronavirus disease 2019 (COVID-19) pandemic has unknown effects on overall population mortality. Previous models mortality are based death over days among infected people, nearly all whom thus far have underlying conditions. Models not incorporated information high-risk conditions or their longer-term baseline (pre-COVID-19) We estimated excess number deaths 1 year under different COVID-19 incidence scenarios varying levels...
Globally, there is a paucity of multimorbidity and comorbidity data, especially for minority ethnic groups younger people. We estimated the frequency common disease combinations identified non-random associations all ages in multiethnic population.In this population-based study, we examined patterns stratified by ethnicity or race, sex, age 308 health conditions using electronic records from individuals included on Clinical Practice Research Datalink linked with Hospital Episode Statistics...
For many diseases there are delays in diagnosis due to a lack of objective biomarkers for disease onset. Here, 41,931 individuals from the United Kingdom Biobank Pharma Proteomics Project, we integrated measurements ~3,000 plasma proteins with clinical information derive sparse prediction models 10-year incidence 218 common and rare (81-6,038 cases). We then compared developed using proteomic data either basic alone or combined 37 assays. The predictive performance including as few 5 20 was...
Flexibility in conceptual projection constitutes one of the most challenging issues embodiment and metaphor literatures. We sketch a theoretical proposal that places burden explanation on attentional dynamics interaction with mental models working memory are constrained to be maximally coherent. A test this theory is provided context time onto domain space. Participants categorized words presented at different spatial locations (back-front, left-right) as referring past or future. Responses...
BackgroundUpdatable estimates of COVID-19 onset, progression, and trajectories underpin pandemic mitigation efforts. To identify characterise disease trajectories, we aimed to define validate ten phenotypes from nationwide linked electronic health records (EHR) using an extensible framework.MethodsIn this cohort study, used eight National Health Service (NHS) datasets for people in England alive on Jan 23, 2020. Data testing, vaccination, primary secondary care records, death registrations...
Both perceptual load theory and dilution purport to explain when why task-irrelevant information, or so-called distractors are processed. Central both explanations is the notion of limited resources, although theories differ in precise way which those limitations affect distractor processing. We have recently proposed a neurally plausible explanation resources neural competition among stimuli hinders their representation brain. This view capacity can also processing, whereby competitive...
A growing literature suggests that the degree to which distracting information can be ignored depends on perceptual load of task, or extent task exhausts capacity. However, there is currently no a priori definition what constitutes high low load. We propose interactions among cells in visual cortex represent nearby stimuli determine and manipulations designed modulate these competitive spatial should distractor processing. found either spatially separating task-relevant items display placing...
Background The medical, health service, societal and economic impact of the COVID-19 emergency has unknown effects on overall population mortality. Previous models mortality are based death over days among infected people, nearly all whom (to date at least) have underlying conditions. Models not incorporated information high risk conditions or their longer term background (pre-COVID-19) We estimated excess number deaths 1 year under different incidence rates differing impacts. Methods Using...
Abstract Introduction We report dementia incidence, comorbidities, reasons for health‐care visits, mortality, causes of death, and examined patterns by relative deprivation in the UK. Method A longitudinal cohort analysis linked electronic health records from 4.3 million people UK was conducted to investigate incidence mortality. Reasons hospitalization death were compared individuals with without dementia. Results From 1998 2016 we observed 145,319 (3.1%) incident Repeated hospitalizations...
Within the range of images that we might categorize as a "beach", for example, some will be more representative category than others. Here first confirmed humans could "good" exemplars better "bad" six scene categories and then explored whether brain regions previously implicated in natural categorization showed similar sensitivity to how well an image exemplifies category. In behavioral experiment participants were accurate faster at categorizing good bad scenes. fMRI passively viewed...
Abstract Background For many diseases there are delays in diagnosis due to a lack of objective biomarkers for disease onset. Whether measuring thousands proteins offers predictive information across wide range is unknown. Methods In 41,931 individuals from the UK Biobank Pharma Proteomics Project (UKB-PPP), we integrated ∼3000 plasma with clinical derive sparse prediction models 10-year incidence 218 common and rare (81 – 6038 cases). We compared based on a) basic alone, b) + 37 biomarkers,...
Abstract The effects of perceptual load on visual cortex response to distractors are well established and various phenomena ‘inattentional blindness’ associated with elimination unattended distractors, have been documented in tasks high load. Here we tested an account for these terms a load-induced trade-off between target distractor processing retinotopic cortex. Participants were scanned using fMRI while performing visual-search task ignoring checkerboards the periphery. Retinotopic...
Despite the growing interest in use of human genomic data for drug target identification and validation, extent to which spectrum disease has been addressed by genome-wide association studies (GWAS), or development, degree these efforts overlap remain unclear.
The UK Biobank (UKB) is making primary care electronic health records (EHRs) for 500 000 participants available COVID-19-related research. Data are extracted from four sources, recorded using five clinical terminologies and stored in different schemas. aims of our research were to: (a) develop a semi-supervised approach bootstrapping EHR phenotyping algorithms UKB EHR, (b) to evaluate by implementing evaluating phenotypes 31 common biomarkers.We describe an algorithmic biomarkers involving...
Assessment of age, sex and smoking-specific risk cancer diagnosis non-cancer mortality following primary care consultation for 15 new-onset symptoms. Data on patients aged 30-99 in 2007-2017 were extracted from a UK database (CPRD Gold), comprising randomly selected reference group symptomatic cohort presenting with one new onset symptoms (abdominal pain, abdominal bloating, rectal bleed, change bowel habit, dyspepsia, dysphagia, dyspnoea, haemoptysis, haematuria, fatigue, night sweats,...
Early diagnosis of cancer relies on accurate assessment risk in patients presenting with symptoms, when screening is not appropriate. But recorded symptoms pre-diagnosis may vary between different sources electronic health records (EHRs), either genuinely or due to differential completeness symptom recording. To assess possible differences, we analysed primary care EHRs the year UK Biobank and Clinical Practice Research Datalink (CPRD) populations linked registry data. We developed...
Despite the vast range of images that we might categorize as an example a particular natural scene category (e.g., beach), human observers are able to quickly and efficiently even briefly presented these scenes. However, within “beach”, for example, some will be more representative than others. We asked whether participants' ability scenes differed depending on were good or bad examples scene. 3000 from six categories (beaches, city streets, forests, highways, mountains offices) first rated...
Abstract Objectives Assessment of age, sex and smoking-specific risk cancer diagnosis non-cancer mortality following primary care consultation for 15 new-onset symptoms. Methods analysis Data on patients aged 18-99 in 2007 – 2017 were extracted from a UK database (CPRD Gold), comprising randomly-selected reference group symptomatic cohort presenting with one new onset symptoms (abdominal pain, abdominal bloating, rectal bleed, change bowel habit, dyspepsia, dysphagia, dyspnoea, haemoptysis,...
Abstract Background The Global Burden of Disease study has provided key evidence to inform clinicians, researchers, and policy makers across common diseases, but no similar effort with single design exists for hundreds rare diseases. Consequently, many conditions lack population-level including prevalence clinical vulnerability. This led the absence evidence-based care prominently in COVID-19 pandemic. Method used electronic health records (EHRs) more than 58 million people England, linking...
Abstract Background Updatable understanding of the onset and progression individuals COVID-19 trajectories underpins pandemic mitigation efforts. In order to identify characterize individual trajectories, we defined validated ten phenotypes from linked electronic health records (EHR) on a nationwide scale using an extensible framework. Methods Cohort study 56.6 million people in England alive 23/01/2020, followed until 31/05/2021, eight national datasets spanning testing, vaccination,...
a través de los cuales esta violencia se ejerce y hace posible, pero también como posibles instrumentos críticos que nos permitan luchar contra ella.