A5048364189- Trypanosoma species research and implications
- Research on Leishmaniasis Studies
- Retinal Diseases and Treatments
- Tuberculosis Research and Epidemiology
- Synthesis and Biological Evaluation
- Synthesis and biological activity
- Advanced Glycation End Products research
- Cancer therapeutics and mechanisms
- Mycobacterium research and diagnosis
- Immune cells in cancer
- Ocular Diseases and Behçet’s Syndrome
- Infectious Diseases and Tuberculosis
- Viral Infections and Vectors
- Viral Infections and Immunology Research
- Cancer-related molecular mechanisms research
- Click Chemistry and Applications
- Mosquito-borne diseases and control
- Vector-borne infectious diseases
- Pneumocystis jirovecii pneumonia detection and treatment
- Systemic Lupus Erythematosus Research
- Burn Injury Management and Outcomes
- Sirtuins and Resveratrol in Medicine
- RNA Research and Splicing
- Bacterial Identification and Susceptibility Testing
- Wound Healing and Treatments
The University of Texas Medical Branch at Galveston
2016-2023
Texas Medical Board
2021
Galveston College
2019
Bipar
2016
Institute of Post Graduate Medical Education and Research
2011-2015
Bose Institute
2014
Bose (United States)
2014
National Institute of Technology Karnataka
2010-2011
University of Calcutta
2009
Trypanosoma cruzi is the causative agent of chronic chagasic cardiomyopathy. Why macrophages (mφs), early responders to infection, fail achieve parasite clearance not known. Mouse (RAW 264.7) and human (THP-1 primary) mφs were infected for 3 h 18 with T. TcI isolates, SylvioX10/4 (SYL, virulent) TCC (nonpathogenic), which represent mφ stimulation infection states, respectively. Mφs incubated lipopolysaccharide gamma interferon (LPS/IFN-γ) interleukin-4 (IL-4) used as controls. We monitored...
New blood vessel formation in the retina because of prolonged hypoxia is believed to be directly associated with increased expression several growth factors and angiogenic cytokines. In present study, we made an attempt investigate possible association promoter polymorphisms interleukin 6, tumor necrosis factor α, 10 for pathogenesis proliferative diabetic retinopathy (PDR).This case-control study comprised 493 volunteers (253 PDR cases 240 controls). Cases controls were ascertained such...
Chronic inflammation and oxidative stress are hallmarks of chagasic cardiomyopathy (CCM). In this study, we determined if microparticles (MPs) generated during Trypanosoma cruzi (Tc) infection carry the host's signature inflammatory/oxidative state provide information regarding progression clinical disease.MPs were harvested from supernatants human peripheral blood mononuclear cells in vitro incubated with Tc (control: LPS treated), plasma seropositive humans a clinically asymptomatic (CA)...
Leprosy is not always an easy disease to diagnose, and patients can remain undiagnosed for longtime, only at the peripheral clinics but also even places with higher medical facilities, so, there urgent need rapid definitive modalities leprosy diagnosis. This prospective study evaluates ability of Fite-Faraco staining (FF staining) multiplex polymerase chain reaction (PCR) over hematoxylin eosin (H E Ziehl-Neelsen (ZN staining).The aim this perspective evaluate effectiveness FF in combination...
Endothelial cell interactions with lipopolysaccharide (LPS) involve both activating and repressing signals resulting in pronounced alterations their transcriptome proteome. Noncoding RNAs are now appreciated as posttranscriptional translational regulators of cellular signaling responses, but expression status roles during endothelial LPS not well understood. We report on the profile long noncoding (lnc) human microvascular cells response to LPS. have identified a total 10,781 8310 lncRNA...
Trypanosoma cruzi (Tc) causes Chagas disease (CD) that is the most frequent cause of heart failure in Latin America. TNF-α+ monocytes/macrophages (Mo/Mφ) are associated with inflammatory pathology chronic CD. In this study, we determined progenitor lineage Mo/Mφ contributing to inflammation and examined regulatory role SIRT1 modulating response disease.C57BL/6 mice were infected Tc, treated agonist (SRT1720) after control acute parasitemia, monitored during phase (150 days post-infection)....
Eales' disease (ED) is an idiopathic retinal vasculitis characterized by capillary nonperfusion and neovascularization. Previous reports on ED demonstrated that T-cell-mediated immunoresponse differential cytokine production in inflammatory angiogenic stage seem to influence the extent severity of this disease. Therefore, purpose study investigate gene polymorphisms occurrence ED.One hundred twenty-one patients with were recruited from Eastern Indian population compared 223 matched healthy...
In Brief Purpose: To evaluate erythrocyte redox state and its surrogates in patients with different stages of diabetic retinopathy their association cellular metabolic derangement developed retinal microvascular cells. Methods: Sixty type 2 nonproliferative (NPDR), 85 proliferative (PDR), 70 diabetes but without were considered as control (DC) for the study. addition, 65 normal individuals enrolled healthy this Erythrocyte oxidized nicotinamide adenine dinucleotide phosphate / reduced (NADP+...
Chagas cardiomyopathy is caused by Trypanosoma cruzi (Tc). We identified two candidate antigens (TcG2 and TcG4) that elicit antibodies T cell responses in naturally infected diverse hosts. In this study, we cloned TcG2 TcG4 a nanovector evaluated whether nano-immunotherapy (referred as nano2/4) offers resistance to chronic disease. For this, C57BL/6 mice were with Tc given nano2/4 at 21 42 days post-infection (pi). Non-infected, infected, treated pcDNA3.1 expression plasmid encoding...
A parasitic protozoan Trypanosoma cruzi (T. cruzi) is the etiologic agent of Chagas disease. Previously, we have identified T. antigens TcG2 and TcG4 as potential vaccine candidates, cloned in eukaryotic expression vector pCDNA3.1 (referred p2/4) tested their ability to elicit protection from infection. In present study, subcloned two a nanoplasmid that optimized for delivery, antigen expression, regulatory compliance standards, evaluated nanovaccine nano2/4) prophylactic against repeat...
Recent discovery that much of the mammalian genome does not encode protein-coding genes (PCGs) has brought widespread attention to long noncoding RNAs (lncRNAs) as a novel layer biological regulation. Enhancer lnc (elnc) from enhancer regions carry capacity regulate PCGs in cis or trans. Spotted fever rickettsioses represent consequence host infection with Gram-negative, obligate intracellular bacteria Genus Rickettsia. Despite being implicated pathways and inflammation, roles lncRNAs...