A5009164025- Colorectal Cancer Surgical Treatments
- COVID-19 and healthcare impacts
- Anorectal Disease Treatments and Outcomes
- Colorectal and Anal Carcinomas
- Radiomics and Machine Learning in Medical Imaging
- Cardiac, Anesthesia and Surgical Outcomes
- Gastric Cancer Management and Outcomes
- Colorectal Cancer Screening and Detection
- Surgical site infection prevention
- Breast Cancer Treatment Studies
- Diverticular Disease and Complications
- Medical Imaging Techniques and Applications
- Ultrasound in Clinical Applications
- Autoimmune and Inflammatory Disorders
- Cancer and Skin Lesions
- Breast Lesions and Carcinomas
- Trauma and Emergency Care Studies
- Inflammatory Bowel Disease
- Appendicitis Diagnosis and Management
- Patient Satisfaction in Healthcare
- Adrenal and Paraganglionic Tumors
- Colorectal Cancer Treatments and Studies
- Body Contouring and Surgery
- Pelvic floor disorders treatments
- Health Systems, Economic Evaluations, Quality of Life
Istanbul University
2015-2025
Amerikan Hastanesi
2023
Koç University
2020-2022
Circulating nucleic acids (CNAs) are under investigation as a liquid biopsy in cancer potential non-invasive biomarkers, stable structure circulation nucleosomes could be valuable sources for detection of cancer-specific alterations histone modifications. Our interest is methylation marks with focus on colorectal cancer, one the leading cancers respective incidence and mortality. previous work included analysis trimethylations lysine 9 3 (H3K9me3) 20 4 (H4K20me3) by chromatin immuno-...
Gastric cancer (GC) is among the most frequent malignant diseases. Despite advances in treatment, clinical outcome of patients with GC remains poor. The establishment novel biomarkers urgently required for early detection, treatment evaluation and prognostic assessment. Non-coding RNAs (ncRNAs) are a key topic intensive research due to their potential applications field oncology. long ncRNA H19 has been frequently reported as overexpressed many cancers including GC. In present study,...
Cytoreductive Surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) are techniques developed for curative treatment of peritoneal carcinomatosis (PC). Studies have shown that CRS + HIPEC provides a survival advantage in PC, long-term can be achieved selected cases. This study aimed to evaluate cases performed purposes examine the prognostic factors. PC patients who underwent with intent between January 2011 September 2022 were included. Demographic, clinical, pathological...
Surgical resection is an unavoidable part of the current treatment options for Crohn's disease (CD), and more than half patients develop recurrence. The aim this study was to investigate predictors recurrence in long-term follow-up CD after surgery.Medical records consecutive who were operated on between January 2003 2015 retrospectively analyzed. Data including demographic clinical characteristics recorded. Recurrence evaluated based Disease Activity Index or endoscopic findings.The...
Background/Aim: Colorectal cancer (CRC) is one of leading cancers in terms incidence and mortality. Interaction tumor cells with the surrounding microenvironment plays a crucial role development progression CRC. Many pathways such as kynurenine pathway, OX40/OX40L-mediated signaling microRNAs targeting PD-L1 may be involved CRC by affecting T cell activation, thus creating an immune-deficient microenvironment. Herein, our goal was to assess association between plasma levels tryptophan (TRP),...
The aim of this study was to determine the correlation between primary tumor (PT) maximum standardized uptake value (SUVmax) and breast cancer prognostic factors, overall survival, relapse-free survival on basis histopathological molecular characteristics.In retrospective study, 436 female patients with were evaluated following a pretreatment F-FDG PET/CT scan. PT SUVmax histopathological/molecular characteristics determined from tissues analyzed using Mann-Whitney U Kruskal-Wallis tests.The...
Appendicitis is the most prevalent surgical emergency. The negative appendicectomy rate and diagnostic uncertainty are important concerns. This study aimed to assess effectiveness of current appendicitis risk prediction models in patients with acute right iliac fossa pain.
Abstract Background We aimed to assess the feasibility and short‐term clinical outcomes of surgical procedures for cancer at an institution using a coronavirus disease 2019 (COVID‐19)‐free pathway during peak phase severe acute respiratory syndrome 2 (SARS‐CoV‐2) pandemic. Materials Methods This was single‐center study, including patients from all departments, who underwent elective first between March 10 June 30, 2020. The primary were rate postoperative SARS‐CoV‐2 infection 30‐day...
Recent randomized trials have shown that completion axillary lymph node dissection (ALND) is not required in all patients with a positive sentinel (SLN) who will receive radiation therapy. Although routine intraoperative pathologic assessment (IPA) becomes unnecessary and less indicated by breast surgeons the United States some European countries, it still widely used around world. In this prospective study, feasibility of nodal palpation (INP) as opposed to IPA SLN has been analyzed....
The prediction of pathological responses for locally advanced rectal cancer using magnetic resonance imaging (MRI) after neoadjuvant chemoradiotherapy (CRT) is a challenging task radiologists, as residual tumor cells can be mistaken fibrosis. Texture analysis MR images has been proposed to understand the underlying pathology.This study aimed assess lesions CRT in patients with first-order textural features MRI T2-weighted (T2-WI) and apparent diffusion coefficient (ADC) maps.Forty-four...
The location of colonic tumors has been linked to different clinical and oncologic outcomes. Transverse colon cancers are generally included as right cancers. Furthermore, hepatic splenic flexure usually components the transverse colon.This study was aimed at comparing clinicopathologic characteristics long-term outcomes between mid-transverse left determining prognostic impact primary tumor in a retrospective study.Two specialized colorectal centers were included.Patients who underwent...
Abstract Background: Over the past few decades, nonoperative management (NOM) has become increasingly prevalent as an effort to preserve organs and improve functional outcomes compared surgery. Objectives: This study aims compare clinical of patients with locally advanced distal rectal cancer (LADRC) following neoadjuvant treatment either total mesorectal excision (TME) or NOM. Design: The was conducted retrospectively. Patients Methods: at two comprehensive centers between January 1, 2014,...
Introduction:: The aim of the study was to develop deep-learning neural networks guide treatment decisions and for accurate evaluation tumor response neoadjuvant chemoradiotherapy (nCRT) in rectal cancer using magnetic resonance (MR) images. Methods:: Fifty-nine tumors with stage 2 or 3 that received nCRT were retrospectively evaluated. Pathological regression grading carried out Dworak (Dw-TRG) guidelines served as ground truth predictions. Imaging-based performed according MERCURY group...
Aim: This nationwide survey study aimed to determine the initial and definitive treatment strategies for pilonidal abscess (PA) that are used by general surgeons in Turkey.Method: Surgeons working at centers Turkey were sent an electronic questionnaire focusing on diagnostic, perioperative, postoperative management options PA.The questions prepared based extensive assessment of literature evaluated usability prior distribution.A consisting 20 was surgical residents via email.The link kept...
This study aims to assess the completeness of pathology reports T1 colorectal cancers from different healthcare centers and change treatment decision after reevaluation polyps.In this single-center retrospective cohort study, several endoscopically excised malignant polyps at diverse in Turkey were reassessed a comprehensive cancer center Istanbul. Reassessment was mainly focused on core elements such as size invasive carcinoma, histologic type grade, tumor extension, surgical margin (deep...
BACKGROUND:The coronavirus disease 2019 (COVID-19) pandemic has affected all aspects of clinical care including diagnosis and treatment colorectal cancers (CRCs) globally, in Türkiye.During the initial peak pandemic, elective surgeries outpatient clinics were restricted addition to government-imposed lockdown, resulting a decrease number colonoscopies being performed patients admitted inpatient wards for CRCs.In this study, we aimed investigate whether presentation characteristics outcomes...
<b> Introduction:</b> F-18 fluorodeoxyglucose (F18-FDG) positron emission tomography-computed tomography (PET/CT) is a valuable functional imaging modality for the clinical diagnosis which provides physiological information based on altered tissue metabolism. </br></br> Aim:</b> This study aims to investigate effectiveness of in preoperative staging and postoperative local recurrence distant metastases patients with rectal cancer. Material methods:</b> The...
BACKGROUND:The novel coronavirus disease 2019 (COVID-19) has resulted in major changes health-care systems and emergency surgical interventions.Here, we examined patients with acute appendicitis who presented to departments compared diagnosis, treatment, post-treatment processes before during the pandemic period investigated how affected management of appendicitis. METHODS:A national, multicenter, cohort study model was designed that included older than 18 years age diagnosed clinically...
e12060 Background: Phyllodes tumor of the breast is a rare fibroepithelial lesion. Appropriate surgical and oncological management remains subject debate. The aim this study was to determine patient outcome characteristics associated with borderline/malignant phylloides . Methods: Between January 1994 October 2014, 102 patients diagnosed phyllodes tumor, were retrospectively analyzed in terms demographic clinicopathologic features treatment modalities. Results: median age 39 (range, 15-84)....