A5024869951- Colorectal Cancer Surgical Treatments
- Colorectal and Anal Carcinomas
- Gastric Cancer Management and Outcomes
- Colorectal Cancer Screening and Detection
- Colorectal Cancer Treatments and Studies
- Anorectal Disease Treatments and Outcomes
- COVID-19 and healthcare impacts
- Genetic factors in colorectal cancer
- Gastrointestinal Tumor Research and Treatment
- Cardiac, Anesthesia and Surgical Outcomes
- Metastasis and carcinoma case studies
- Ovarian cancer diagnosis and treatment
- Stoma care and complications
- Intraperitoneal and Appendiceal Malignancies
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer-related gene regulation
- Appendicitis Diagnosis and Management
- Diverticular Disease and Complications
- Hepatocellular Carcinoma Treatment and Prognosis
- Epigenetics and DNA Methylation
- Trauma and Emergency Care Studies
- Enhanced Recovery After Surgery
- Gastrointestinal disorders and treatments
- Esophageal Cancer Research and Treatment
- Radiomics and Machine Learning in Medical Imaging
Koç University
2014-2025
Amerikan Hastanesi
2011-2025
Istanbul University
1991-2023
Institut de Virologie
2020-2022
Urology Foundation
2021
University of Birmingham
2020-2021
NIHR Birmingham Biomedical Research Centre
2021
Yorkshire Cancer Research
2021
Association for Cancer Surgery
2021
AstraZeneca (Brazil)
2020
The purpose of this study was to investigate the potential therapeutic roles honey, prednisolone and disulfiram in an experimental model inflammatory bowel disease. Another aspect find out whether these substances have any effect on nitric oxide (NO) free radical production.After induction colitis with trinitrobenzene sulfonic acid 64 male rats, physiological saline, enemas were applied rats once daily for 3 days (acute treatment groups) or 7 (chronic groups). Control groups received only...
There is growing evidence describing DNA repair genes polymorphisms are related to increased cancer risk including colorectal (CRC). The aim of this study was investigate the associations between APE1 Asp148Glu, hOGG1 Ser326Cys, XRCC1 Arg399Gln, XRCC3 Thr241Met, XPD Lys751Gln, XPG Asp1104His and CRC in Turkish population.Polymorphisms Asp148Glu (rs3136820), Ser326Cys (rs1052133), Arg399Gln(rs25487), Thr241Met (rs861539), Lys751Gln (rs13181), (rs17655) were determined by polymerase chain...
Journal Article Recurrence patterns and post-recurrence survival of patients with bilobar colorectal liver metastases: international multicentre retrospective study Get access Bilobar CRC Liver Metastases Research Collaborative Search for other works by this author on: Oxford Academic Google Scholar British Surgery, Volume 112, Issue 3, March 2025, znaf003, https://doi.org/10.1093/bjs/znaf003 Published: 04 2025 history Received: 19 2024 Revision received: 24 September Accepted: 03 January
Clinical diagnosis of appendicitis is usually made on the basis history, physical examination and laboratory studies. Approximately 30-45% patients with suspected present atypical clinical findings. Recently graded compression ultrasound thin section unenhanced helical CT have been used to establish for acute appendicitis. The purpose this study was determine diagnostic accuracy protocol in adult scans obtained when presented right lower quadrant pain impression equivocal were evaluated. Of...
The optimum duration between neoadjuvant radiochemotherapy and transmesorectal excision in locally advanced rectal cancer has not been defined yet. This randomized study was designed to compare the efficacy of four-week versus eight-week delay before surgery.One-hundred fifty-three patients with low- or mid-rectum adenocarcinoma were included this single center prospective trial. Patients assigned receive surgical treatment after either four weeks eight chemoradiotherapy. followed for local...
Condyloma acuminata are anogenital warts caused by human papillomavirus (HPV). Neglected giant peri-anal condyloma (Buschke Loewenstein Tumours) require major surgical procedures. This report reflects our experience concerning the aggressive approach to this rarely presented type of acuminata.The medical records five patients, who had been surgically treated following diagnosis perianal between April, 1996 and September, 2003 were reviewed evaluated retrospectively. Full thickness tumour...
AbstractPurpose: A rare complication of laparoscopic cholecystectomy is defined: iatrogenic injuries to hepatic artery system which may evolve pseudoaneurysms in the late postoperative period. This phenomenon be overlooked and pose a challenge surgeons.Material methods: We will describe three cases with after cholecystectomy.The onset symptoms course disease was not uniform. Diagnosis made considerable delay. In first case, small, uncomplicated extrahepatic pseudoaneurysm successfully...
Background. The authors aimed to investigate the effects of montelukast (ML) on experimental rat colon anastomosis. Methods. A total 80 Wistar albino rats were divided into 4 groups: sham-operated, anastomosis, and anastomosis with oral administration (OAML) rectal 10 mg/kg/d ML (RAML). Anastomotic bursting pressure, anastomotic hydroxyproline contents, malondialdehyde (MDA), glutathione (GSH), peroxidase (GPX), superoxide dismutase (SOD) levels, expressions Ki-67, vascular endothelial...
To compare the surgical outcomes of stapled and handsewn closures in loop ileostomies.The data 225 patients requiring ileostomies from 2002 to 2007 were retrospectively evaluated. The underwent partial small-bowel resections either or anastomoses for ileostomy closures. They followed up postoperatively with routine examinations.The study group consisted 124 men 101 women a mean age 49.12 years. closure was performed 129 96 patients. time first postoperative flatus 2.426 days 2.052 (p <0.05)....
The inactivation of the cyclin-dependent kinase inhibitor p16INK4A gene by hypermethylation is observed in numerous types cancer. New findings indicate that DNA and histone methylation act concert silencing. In this study, we investigated status promoter 3 lysine 9 residue tumors matched normal tissue samples from patients with colorectal cancer analyzed their association expression. expression were real-time PCR, was chromatin immunoprecipitation followed PCR. significantly higher compared...
Phosphatase and tensin homolog (PTEN) is one of the most frequently mutated suppressor genes in human cancers. However, there are no data about role PTEN IVS4 polymorphism development colorectal cancer (CRC). The authors aimed to determine variants etiology CRC.A hospital-based case-control study was conducted 203 patients with CRC (127 colon, 76 rectum) 245 healthy controls. frequencies (rs 3830675) genotypes were determined by using a polymerase chain reaction-restriction fragment length...
Peroxisome proliferator-activated receptor gamma (PPARγ) is a ligand dependent transcription factor involved in various processes, including carcinogenesis. We aimed to investigate any possible association of the PPARγPro12Ala (rs1801282) polymorphism with risk developing gastric cancer (GC).A hospital based case control study was designed covering 50 patients GC and 120 healthy controls. The frequencies were determined using polymerase chain reaction-restriction fragment length (PCR-RFLP)...
Bilobar liver metastases from colorectal cancer pose a challenge for obtaining satisfactory oncological outcome with an adequate future remnant. This study aimed to assess the clinical and pathological determinants of overall survival recurrence-free among patients undergoing surgical clearance bilobar cancer.
Gastric carcinoma remains one of the leading causes cancer-related death in world. Clinical studies have revealed that approximately two thirds patients seek treatment for early recurrence within abdominal cavity. The aim this phase II study was to evaluate toxicity, feasibility, and efficacy adjuvant intraperitoneal chemotherapy (IPCT) with cisplatin, mitoxantrone, 5-fluorouracil (5-FU), folinic acid stage II-III gastric cancer. Patients III cancer aged between 15 70 years, after curative...