Abstract Aims We aimed to evaluate the retinal microvascular and structural changes in intracranial hypertension (IH) patients compared with an age‐ sex‐matched control group. also investigated association between clinical parameters IH patients. Methods Intracranial were divided into eyes papilledema (IH‐P) without (IH‐WP). underwent lumbar puncture measure pressure (ICP); visual acuity was performed using Snellen chart. Optical coherence tomography (OCT) used image nerve fiber layer (RNFL)...

Background Retinal ischemic perivascular lesions (RIPLs) are an indicator of ischemia in the middle retina. We aimed to determine relationship between RIPLs and single subcortical infarction (SSI). also investigated differences cerebral small vessel disease imaging burden groups with without SSI. Methods Results In this case–control study, we enrolled 82 patients SSI 72 nonstroke controls. All participants underwent magnetic resonance swept‐source optical coherence tomography/optical...

Objectives: To investigate the correlation between iron deposition changes in lesioned thalamic nuclei and presence severity of central post-stroke pain (CPSP) after infarction using quantitative susceptibility mapping (QSM) technique. Methods: We consecutively enrolled patients with unilateral chronic radiological examination conformed . Detailed multidimensional characteristics measured as follows: Douleur Neuropathique 4 (DN4) questionnaire for validation neuropathic diagnosis, Short-Form...

Background: Occurrence of post-stroke apathy (PSA) is associated with worse outcomes and poorer quality life. Particularly, post-thalamic stroke was repeatedly reported. In this study, we performed disconnection-based analyses to reveal the neural basis from both focal network perspectives. Method: This study recruited first-ever unilateral thalamic ischemic patients. The Lille Apathy Rating Scale used characterize appearance severity apathy. Patient’s lesion masks were embedded into...

Background: Ischemic thalamic stroke often leads to cognitive and emotional dysfunctions, yet the link between these deficits structural brain changes remains unclear. This study explores association gray matter volume alterations neuropsychological assessments in ischemic patients, aiming elucidate basis of neuropsychiatric deficits. Methods: Patients with first-time unilateral were recruited from West China Hospital, Sichuan University (October 2021 - December 2023). Inclusion criteria...

ABSTRACT Aims Early neurological deterioration (END) is a relatively common occurrence among patients with single subcortical infarctions (SSI). Accurate and early prediction of END in SSI challenging could contribute to enhancing prognosis. Methods This prospective observational study enrolled who arrived within 24 h from symptom onset at center between December 2020 March 2023. The least absolute shrinkage selection operator (LASSO) regression model was applied optimize feature for the...

Abstract INTRODUCTION Regional brain iron dyshomeostasis is observed in cerebral small vessel disease (cSVD) and other neurodegeneration processes. However, its spatial patterns, cognitive impact, underlying pathological mechanisms remain unclear. METHODS Voxel‐based analysis of quantitative susceptibility mapping (QSM) was used to detect regional changes, their correlations with function were assessed using linear regression. We combined the microarray dataset from Allen Human Brain Atlas...

Background: The retina and brain share similar neuronal microvascular features. We aimed to investigate the retinal thickness microvasculature in patients with thalamic infarcts compared control participants. Material methods: Swept-source optical coherence tomography (SS-OCT) was used image macular (retinal nerve fiber layer, RNFL; ganglion cell-inner plexiform GCIP), while OCT angiography (superficial vascular plexus, SVP; intermediate capillary ICP; deep DCP). Inbuilt software measure...

Purpose: Retinal microvascular changes are associated with ischemic stroke, and optical coherence tomography angiography (OCTA) is a potential tool to reveal the retinal microvasculature. We investigated feasibility of using OCTA image automatically identify stroke its subtypes (i.e. lacunar non–lacunar stroke), exploited association biomarkers stroke. Methods: Two cohorts were included in this study total 1730 eyes from 865 participants studied. A deep learning model was developed...

Background: We aimed to assess the retinal structural and choroidal changes in carotid artery stenosis (CAS) patients their association with cerebral hemodynamic changes. Asymptomatic symptomatic unilateral CAS were enrolled our study. Material methods: Swept-source optical coherence tomography (SS-OCT) was used image nerve fiber layer (RNFL), ganglion cell-inner plexiform (GCIPL), while SS-OCT angiography (SS-OCTA) measure vascular volume (CVV) index (CVI). Computed Tomography Perfusion...

Objectives To investigate the association between degeneration of retinal structure and shrinkage optic tract in patients after thalamic stroke. Materials methods Patients with unilateral stroke were included. Structural magnetic resonance imaging (MRI) optical coherence tomography (OCT) performed to obtain parameters (lateral index) retina structural thickness (retinal nerve fiber layer, RNFL; peripapillary pRNFL; ganglion cell-inner plexiform GCIP), respectively. Visual acuity (VA)...

Abstract Background and objective Neuro‐ophthalmologic symptoms retinal changes have been increasingly observed following thalamic stroke, there is mounting evidence indicating distinct alterations occurring in the vision‐related functional network. However, intrinsic correlations between these are not yet fully understood. Our was to explore altered patterns of network connectivity retina parameters, their with visual performance patients stroke. Methods We utilized resting‐state MRI obtain...

It is unclear whether non-high-density lipoprotein cholesterol (Non-HDL-C) associated with haemorrhagic transformation (HT) after acute ischaemic stroke (AIS). We aimed to explore the association between Non-HDL-C and HT, as well compare predictive values of low-density (LDL-C) for HT.We consecutively enrolled AIS patients within 7 days onset. Participants were divided into four categories according quartiles Non-HDL-C. HT was assessed by follow-up brain imaging. Non-HDL-C, LDL-C in...

Hemorrhagic transformation (HT) has an adverse effect on the prognosis of patients with acute ischemic stroke, and it is currently known associated coagulation system. But conclusion not consistent remains to be identified. The aim this study was investigate association between function spontaneous hemorrhagic transformation.Patients within 7 days from onset stroke who did receive reperfusion therapy (thrombolysis or endovascular treatment) were included January 2016 October 2017....

To the Editor: Recent single subcortical infarction (RSSI), formerly known as lacunar stroke, is a neurological syndrome that occurs when small perforating artery in brain becomes blocked, resulting ischemia and impairment.[1] Radiological indicators of cerebral vessel disease (SVD), such lacunes white matter hyperintensity (WMH), have gained increasing attention because their role cognitive impairment dementia.[1] The correlation among radiological enables investigation impact on both...

Abstract Aims Cerebrovascular lesions in the primary visual cortex, lateral geniculate nucleus, and optic tract have been associated with retinal neurodegeneration via retrograde degeneration (RD) mechanism. We aimed to use optical coherence tomography (OCT) assess effects of strategic single subcortical infarction (SSI) location on its longitudinal impacts. Methods Patients SSI were enrolled stratified by lesion cerebral MRI into thalamic group extra‐thalamic group. Healthy controls from...

Background: Hemorrhagic transformation (HT) after reperfusion therapy for acute ischemic stroke (AIS) has been well studied; however, there is scarce research focusing on spontaneous HT (sHT). Spontaneous no less important with a relatively high incidence and could be associated neurological worsening. We aimed to develop validate simple practical model predict sHT AIS (SHAIS) compared the predictive value of SHAIS score against models post-Reperfusion sHT. Methods: Patients admitted within...

Introduction and Hypothesis: Neuro-ophthalmologic symptoms retinal changes have been increasingly observed following thalamic stroke, there is mounting evidence indicating distinct alterations occurring in the vision-related functional network. However, intrinsic correlations between these are not yet fully understood. Our objective was to explore altered patterns of network connectivity retina parameters, their with visual performance patients stroke. Methods: We utilized resting-state MRI...

Introduction and Hypothesis: As the most frequent subtype of central post-stroke pain (CPSP), CPSP thalamic origin can often be refractory to treatments affect long-term prognosis thalamic-stroke patients, while mechanism remains unclear. We assumed that post-thalamic stroke might a brain network disorder aimed investigate alterations in patients explore whether these changes underlie clinical symptoms. Methods: A total 92 participants were finally enrolled, whom 62 chronic (26 had CPSP) 30...

Background . Potassium and sodium are inextricably linked to the maintenance of cell potential electrolyte homeostasis. Few studies have examined their joint relationship with outcomes after stroke. The objective this study is ascertain whether combined low nadir serum potassium levels correlated an unfavorable outcome in ischemic Methods Retrospective cohort 2,920 consecutive patients first‐ever Serum were measured at 10 time points over days poststroke. Youden Index was performed identify...

Abstract Background Clinical outcomes vary considerably among patients with acute single subcortical infarction (SSI). We aimed to construct a model incorporating radiomic features and clinical factors predict functional in SSI. Methods enrolled who experienced SSI within 14 days of stroke onset randomly divided them into training (n=118) test (n=30) cohorts. Unfavorable outcome was defined as modified Rankin Scale score >1 at 3 months. extracted selected radiomics from baseline...

This study aimed to investigate the association between iron content in grey matter (GM) nuclei and functional outcome acute ischaemic stroke (AIS) patients utilizing quantitative susceptibility mapping.

(1) Introduction: Symptom spectrum can be of great diversity and heterogeneity in mitochondrial encephalomyopathy, lactic acidosis, stroke-like episodes (MELAS) patients clinical practice. Here, we report a case MELAS presenting asymptomatic refractory hypotension with m.3243 A>G mutation. (2) Case representation: A 51-year-old male patient presented headache, vertigo, difficulty expression understanding. The magnetic resonance imaging the brain revealed an acute lesion involving left...