A5076512740- Cannabis and Cannabinoid Research
- Neuroscience and Neuropharmacology Research
- Peroxisome Proliferator-Activated Receptors
- Fatty Acid Research and Health
- Sleep and Wakefulness Research
- Epigenetics and DNA Methylation
- Diet and metabolism studies
- Adipose Tissue and Metabolism
- Nuclear Receptors and Signaling
- Neuroscience of respiration and sleep
- Animal Genetics and Reproduction
- Stress Responses and Cortisol
- Folate and B Vitamins Research
- Nanoplatforms for cancer theranostics
- Nitric Oxide and Endothelin Effects
- Histone Deacetylase Inhibitors Research
- Mitochondrial Function and Pathology
- Alcohol Consumption and Health Effects
- Electrospun Nanofibers in Biomedical Applications
- Tryptophan and brain disorders
- RNA regulation and disease
- Adenosine and Purinergic Signaling
- GDF15 and Related Biomarkers
- Prenatal Substance Exposure Effects
- Quantum Dots Synthesis And Properties
Universidade Federal do Rio de Janeiro
2017-2024
Universidade Federal de Pernambuco
2013-2023
Major depressive disorder (MDD) is a major cause of disability in adults. MDD both comorbidity and risk factor for Alzheimer's disease (AD), regular physical exercise has been associated with reduced incidence severity AD. Irisin an exercise-induced myokine derived from proteolytic processing fibronectin type III domain-containing protein 5 (FNDC5). FNDC5/irisin the brains AD patients mouse models. However, whether brain expression altered depression remains elusive. Here, we investigate changes
The endocannabinoid system (eCS) is widely distributed in mammalian tissues and it classically formed by cannabinoid receptors, endogenous bioactive lipids its synthesis degradation enzymes. Due to the modulatory role of eCS synaptic activity Central Nervous System (CNS), phytocannabinoids have been increasingly used for treatment neurological disorders, even though little known terms long-term effect these treatments on CNS development, mainly timeframe that comprises childhood adolescence....
Age increases the risk for cognitive impairment and is single major factor Alzheimer's disease (AD), most prevalent form of dementia in elderly. The pathophysiological processes triggered by aging that render brain vulnerable to involve, at least part, changes inflammatory mediators. Here we show lipoxin A4 (LXA4), a lipid mediator inflammation resolution known stimulate endocannabinoid signaling brain, reduced central nervous system. We demonstrate genetic suppression 5-lipoxygenase...
The endocannabinoid system (ECS) refers to a complex cell-signaling highly conserved among species formed by numerous receptors, lipid mediators (endocannabinoids) and synthetic degradative enzymes. It is widely distributed throughout the body including CNS, where it participates in synaptic signaling, plasticity neurodevelopment. Besides, olfactory ensheathing glia (OEG) present also known play an important role promotion of axonal growth and/or myelination. Therefore, both OEG ECS promote...
Glioblastoma (GBM) is the most aggressive and infiltrating primary tumor of central nervous system (CNS), showing a variety mutations high degree vascularity, cell polymorphism, nuclear atypia. GBM treatment often recurs to surgical resection, but such protocol lacks efficacy since complete removal not entirely successful due invasive cells that cannot be detected at moment surgery. Here, we describe new in vivo targeting imaging method for detection an orthotropic mouse model using...
Abstract Background Alzheimer’s disease (AD) is the leading cause of dementia in elderly humans worldwide. More than 40 million people currently suffer from AD, and this prevalence tends to increase considerably coming decades due increased longevity. The unfolded protein response (UPR) an adaptive signaling mechanism that aims maintain cell viability under misfolded accumulation endoplasmic reticulum stress. UPR activation associated with neurodegenerative diseases, such as synaptic loss...
Abstract Background Alzheimer’s disease (AD) is the most prevalent neurodegenerative worldwide. More than 40 million people currently suffer from AD, and such prevalence tends to increase considerably in coming decades due increased human longevity. Nonetheless, despite intense research efforts, no therapy has yet proven effective attenuating or reversing progression of AD. The unfolded protein response (UPR) an adaptive signaling mechanism that aims maintain cell viability under folding...