A5100411148- Breast Lesions and Carcinomas
- Breast Cancer Treatment Studies
- Lymphoma Diagnosis and Treatment
- Retinal Diseases and Treatments
- Retinal Imaging and Analysis
- Radiomics and Machine Learning in Medical Imaging
- Metastasis and carcinoma case studies
- Lymphatic System and Diseases
- Endometrial and Cervical Cancer Treatments
- Retinal and Optic Conditions
- Multiple Sclerosis Research Studies
- Long-Term Effects of COVID-19
- Cancer Risks and Factors
- Chronic Lymphocytic Leukemia Research
- Vitamin D Research Studies
- Genetic factors in colorectal cancer
- MRI in cancer diagnosis
- Fetal and Pediatric Neurological Disorders
- Vascular Malformations Diagnosis and Treatment
- HER2/EGFR in Cancer Research
- Salivary Gland Tumors Diagnosis and Treatment
- Prenatal Screening and Diagnostics
- CAR-T cell therapy research
- Digital Radiography and Breast Imaging
- Cardiac Arrest and Resuscitation
Shantou University
2025
Cancer Hospital of Shantou University Medical College
2025
Longhua Hospital Shanghai University of Traditional Chinese Medicine
2019-2025
Shanghai University of Traditional Chinese Medicine
2019-2025
Columbia University
2022-2024
The Affiliated Yongchuan Hospital of Chongqing Medical University
2021-2023
Chongqing Medical University
2021-2023
University of Alabama at Birmingham
2021-2023
Chinese PLA General Hospital
2022
Tianjin Central Hospital of Gynecology Obstetrics
2022
Invasive micropapillary carcinoma (IMPC) of the breast is characterized by a high incidence axillary lymph node metastasis. To investigate relationship between pathologic features and metastasis, 51 cases with IMPC components were studied. Immunohistochemical analysis for vascular endothelial growth factor (VEGF)-C VEGF receptor (VEGFR)-3 was performed, lymphatic vessel density measured. The main findings included significantly increased number positive nodes and/or an rate metastasis in...
To investigate intraretinal neovascularization and microvascular anomalies by correlating in vivo multimodal imaging with corresponding ex histology a single patient.A case study comprising clinical from community-based practice, histologic analysis at university-based research laboratory (clinicopathologic correlation).A White woman her 90s treated numerous intravitreal anti-VEGF injections for bilateral type 3 macular (MNV) secondary to age-related degeneration (AMD).Clinical comprised...
We have previously shown that vitamin D deficiency has a detrimental impact on lung development. In this study, we aimed to identify the mechanisms linking with development using mouse model of dietary manipulation. Female offspring were euthanized at different time-points; embryonic day (E)14.5, E17.5 or postnatal (P)7. Lung tissue was collected for mass spectrometry-based proteomic analysis. Label-free quantitation used differentially expressed proteins and ELISA confirmed expression...
Patients with recurrent endometrial cancer treated carboplatin and paclitaxel whose disease progresses have few effective treatment options. Based on promising clinical trial data, the anti-programmed cell death 1 (anti-PD-1) antibody dostarlimab was recently granted accelerated approval for by US Food Drug Administration. We developed a decision model to examine cost-effectiveness of patients progressive/recurrent deficient mismatch repair (dMMR) has progressed first-line...
Granulomatous lobular mastitis (GLM) is a rare, benign, and complex breast disease that can be easily misdiagnosed as cancer. The etiology of GLM unclear, optimal treatment has not been established.Medical records for 333 patients with in recent 5 years at Longhua Hospital, Shanghai, China, were analyzed. Potential pathogens 33 fresh tissue specimens also analyzed using 16S rDNA sequencing technology, matrix-assisted laser desorption ionization time flight mass spectrometry, bacterial...
Abstract Purpose: To enable in vivo analysis of drusen composition and lifecycle, we assessed macular nodular cuticular using histology. Methods: Median interquartile range (IQR) base widths single (non-confluent) 3 sources were determined histologically: 43 eyes clinically undocumented donors, an online resource; one eye with punctate hyperfluorescence fluorescein angiography (FA); two patient bilateral “starry sky” drusen. All tissues processed for high-resolution epoxy-resin histology...
Although the expression of T-cell antigens and proteins associated with tumor-infiltrating T-lymphocytes (TILs), regulatory T cells (T-regs), B-cell development have been evaluated in classical Hodgkin lymphoma (cHL), few studies correlate these proteins’ patterns clinical outcome. The purpose this study was to evaluate expressed Reed-Sternberg (RSCs) TILs cHLs at initial diagnosis determine their prognostic significance. 12 RSCs from 88 diagnostic cHL biopsies quantitated correlated overall...
Abstract Background and objectives Malignant phyllodes tumor of the breast (MPTB) is a kind rare tumor. Our objective was to investigate role adjuvant radiotherapy (RT) in MPTB patients. Methods patients were identified Surveillance, Epidemiology End Results (SEER) database. Kaplan–Meier curves multivariable Cox proportional hazards analyses conducted determine effect RT on Propensity-score matching (PSM) method used balance clinicopathological characteristics. A total 1353 included our...
Plasma cell mastitis is a benign suppurative disease of the breast, lack specific clinical manifestations, which easy to be misdiagnosed and mistreated, often confused with mastitis, breast cancer (BC), other diseases. Thus, we aimed establish combined model promoting diagnostic accuracy plasma by contrast-enhanced ultrasound (CEUS) patterns routine blood analysis. Eighty-eight 91 cancer, 152 diseases’ patients grouped according pathological diagnosis underwent CEUS analysis examination; 100...
Abstract Objective To compare multiple breast cancer screening methods for evaluating non-mass-like lesions (NMLs), and investigate new best method the value of lexicon ACR BI-RADS in NML evaluation. Methods This retrospective study examined 253 patients aged 24–68 years who were diagnosed with NMLs described from April 2017 to December 2019. All evaluated by HHUS, MG, ABUS determine category, underwent pathological examination within six months or at least 2 follow-up. The sensitivity,...
Abstract Objective The purpose of this study was to reevaluate the high-risk breast non-mass-like lesions (NMLs) in mammography (MG) by target ultrasound (US) and Automated ultrasonography (ABUS), analyze correlation between different imaging findings factors influencing classification lesions. Methods A total 161 patients with 166 were recruited retrospectively study. All cases diagnosed as BI-RADS 4 or 5 MG NML on ultrasound. While all NMLs underwent mammography, US ABUS before surgery...
Metaplastic breast carcinoma (MBCs) is a rare heterogeneous group of malignancies. Herein, we report case metaplastic carcinoma, which had 2 components. One them was typical invasive ductal (IDC), the other one presenting as osteosarcoma with lots immature trabeculae. The results immunohistochemistry showed different presentations between them. majority MBCs show triple-negativity for ER, PR, and HER-2 are thus associated poor prognosis. Our shows that, it necessary to describe proportion...
Cavernoma is the second most common cerebrovascular lesion. involving cranial nerves very rare. Only 15 cases of cavernoma presenting with trigeminal neuralgia (TN) have been previously reported. Here, we report a rare case manifesting TN. A young female patient 15-day history right-sided lancinating pain in face, difficulty opening mouth, and hearing dysesthesia. Magnetic resonance imaging (MRI) revealed well-demarcated lesion cerebellopontine angle related closely to root nerve. The...
Low circulating levels of 25-hydroxyvitamin D [25(OH)D] are associated with chronic lung diseases such as asthma. However, it is unclear whether vitamin involved in disease pathogenesis or modified by the inflammation process. We hypothesized that allergic decreases level 25(OH)D and tested this using a mice model house dust mite (HDM) induced airway inflammation. Cellular influx was measured bronchoalvelar lavage (BAL) fluid, sensitization were serum. Exposure to HDM caused robust...