A5101619275- Ubiquitin and proteasome pathways
- Stochastic processes and statistical mechanics
- NF-κB Signaling Pathways
- Probability and Risk Models
- Melanoma and MAPK Pathways
- Protein Kinase Regulation and GTPase Signaling
- Markov Chains and Monte Carlo Methods
- RNA Research and Splicing
- Cytokine Signaling Pathways and Interactions
- Immune Response and Inflammation
- interferon and immune responses
- Healthcare and Venom Research
- Sperm and Testicular Function
- Stochastic processes and financial applications
- Peptidase Inhibition and Analysis
- PI3K/AKT/mTOR signaling in cancer
- CRISPR and Genetic Engineering
- Cancer-related molecular mechanisms research
- Statistical Methods in Clinical Trials
- Advanced Queuing Theory Analysis
- T-cell and B-cell Immunology
- Medicinal Plant Pharmacodynamics Research
- Protein Degradation and Inhibitors
- Cancer-related Molecular Pathways
- Protein Tyrosine Phosphatases
Sun Yat-sen University
2013-2025
Shinawatra University
2025
Changsha University of Science and Technology
2007-2024
Hunan University of Traditional Chinese Medicine
2013-2024
Dalian Neusoft University of Information
2010-2023
Jiangsu Normal University
2023
Guangxi University
2022
Biocon (Switzerland)
2021
Air Force Institute of Aviation Medicine Affiliated Hospital
2013-2014
Dalian University of Technology
2012
Abstract Background Prostate cancer (PCa) incidence and mortality rates are rising. Our previous research has shown that the combination of icariin (ICA) curcumol (CUR) induced autophagy ferroptosis in PCa cells, altered lipid metabolism. We aimed to further explore effects ICA CUR on gut microbiota, metabolism, immunity PCa. Methods A mouse subcutaneous RM-1 cell tumor model was established. 16 S rRNA sequencing performed detect changes fecal microbiota. SCFAs feces, effect ICA-CUR T-cell...
Monitoring and predicting ground vibration levels during blasting operations is essential to safeguard mining sites surrounding communities. This study introduces an IoT-based monitoring device specifically designed for limestone operations, combined with machine learning algorithms predict intensity. The primary aim provide efficient predictive tool anticipating hazardous levels, enabling proactive safety measures. A comparative analysis the industry-standard Minimate Blaster indicates high...
Abstract Immunotherapy has revolutionized cancer treatment by leveraging the patient's immune system, yet its efficacy is often hampered immunosuppressive tumor microenvironment (TME). Adenosine, a key player in this milieu, suppresses cell activity via cAMP signaling. Here, an innovative strategy to remodel TME using genetically engineered strain of Escherichia coli Nissle 1917 that expresses adenosine deaminase on surface under hypoxic conditions presented. This probiotic targets tumors,...
B ‐lymphoma mouse Moloney leukemia virus insertion region 1 ( mi1), a member of the polycomb group, has elevated expression and is involved in pathogenesis various aggressive cancers, including nasopharyngeal carcinoma NPC ). To date, mechanisms underlying high mi1 remain obscure. gain new insights into transcriptional regulation BMI1 , we cloned characterized promoter . Luciferase reporter assays demonstrated that from −783 to +375 showed significant activity. With use series 5′‐deletion...
Abstract Genes with cross-cancer aberrations are most likely to be functional genes or potential therapeutic targets. Here, we found a total of 137 were ectopically expressed in eight cancer types, which Holliday junction recognition protein ( HJURP ) was significantly upregulated prostate (PCa). Moreover, patients higher mRNA and levels had poorer outcomes, the served as an independent prognosis factor for overall survival PCa patients. Functionally, ectopic expression promoted cells...
Docetaxel (DTX) resistance reduces therapeutic efficacy in prostate cancer (PCa). Accumulating reports support the role of phytochemicals reversal DTX resistance. This study aimed to determine whether Epimedium brevicornu and Curcuma zedoaria extracts (ECe), specially icariin-curcumol, attenuates explore their potential mechanisms.Regulatory pathways were predicted between ECe active ingredients PCa using network pharmacology. DTX-resistant cell LNCaP/R established based on DTX-sensitive...
A novel protein kinase whose activity can be stimulated by mitogen in vivo was cloned and characterized. The cDNA of this gene encodes an 802-amino acid (termed RLPK) with the highest homology (37% identity) to two families, p90RSK p70RSK. Like p90RSR, but not p70RSK, RLPK also contains complete nonidentical domains. mRNA is widely expressed all human tissues examined enriched brain, heart, placenta. In HeLa cells, transiently epitope-tagged strongly induced epidermal growth factor, serum,...
NF-kappaB is a family of essential transcription factors involved in both embryonic development and inflammatory responses the immune system. can be activated by two pathways, i.e. canonical (NF-kappaB1) pathway, which acts through catalytic components IkappaB kinase complex leads to phosphorylation, degradation, subsequent nuclear translocation, or non-canonical (NF-kappaB2) involves NF-kappaB-induced kinase-dependent proteolytic processing p100/p52 yield translocation-competent...
The aim of the present study was to determine a suitable procedure for treatment chest wall neoplasms with less potential risk and an increased rate survival. Fifty patients suspected malignancies were analyzed using various preliminary investigation tools. Whole-chest scanning performed in all patients. subsequently subjected biopsies further confirmation neoplasm. All such then treated surgical approach radiation therapy, follow-up period lasting up six years. majority showed improved...
Abstract Using a new approach, for spectrally negative Lévy processes we find joint Laplace transforms involving the last exit time (from semiinfinite interval), value of process at time, and associated occupation which generalize some previous results.
Ferroptosis is a form of regulatory cell death that relies on iron and reactive oxygen species (ROS) to inhibit tumors. The present study aimed investigate whether icariin‑curcumol could be novel ferroptosis inducer in tumor inhibition. Various concentrations were used stimulate prostate lines (RWPE‑2, PC‑3, VCAP DU145). Small interfering negative control (si‑NC) si‑nuclear factor erythroid 2‑related 2 (Nrf2) transfect DU145 cells. Cell viability was determined by using counting kit‑8....
TNFR-associated factor (TRAF)6 is an essential ubiquitin E3 ligase in immune responses, but its function adaptive immunity not well understood. In this study, we show that TRAF6 recruited to the peripheral ring of T cell immunological synapse Jurkat cells or human primary CD4(+) conjugated with staphylococcal enterotoxin E-pulsed B cells. This recruitment depends on interacting linker for activation (LAT) via TRAF domain. Although LAT was indispensable TCR/CD28-induced ubiquitination and...
p38-interacting protein (p38IP) is a component of the GCN5 histone acetyltransferase-containing coactivator complex (GCN5-SAGA complex). It remains unclear whether p38IP or GCN5-SAGA involved in cell cycle regulation. Using RNA interference to knock down p38IP, we observed that cells were arrested at G2/M phase, exhibiting accumulation cyclins, shrunken spindles, and hypoacetylation α-tubulin. Further analysis revealed knockdown led proteasome-dependent degradation GCN5. associated with...
Monocyte/macrophage differentiation represents a major branch of hematopoiesis and is central event in the immune response, but molecular mechanisms underlying are not fully delineated. Here we show that p38 mitogen-activated protein kinase (MAPK) interacting (p38IP) downregulated during monocyte/macrophage vitro. Overexpression p38IP halted differentiation, whereas forward knockdown by RNA interference induced G1/S arrest promoted monocyte into macrophages maturation as well. Moreover,...
Abstract MAP kinases have important role in PC12 cell differentiation, since the activities of both extracellular regulated protein kinase (ERK) and p38 been indicated as necessary signal for differentiation. Epidermal growth factor (EGF) NGF activate ERK cells, but only trigger It has proposed that duration activation determines switch from proliferation to EGF causes more transient than cells. Here we report treatment cells with presence SB203580, a widely used inhibitor, caused The...
Colorectal cancers (CRC) can be classified into four consensus molecular subtypes (CMS), among which CMS1 has the best prognosis, contrasting with CMS4 that worst outcome. CRC is notoriously resistant against therapeutic interventions, as demonstrated by preclinical studies and retrospective clinical observations. Here, we report finding two clinically employed agents, everolimus (EVE) plicamycin (PLI), efficiently target prototypic cell line MDST8. As compared to LoVo, MDST8 cells treated...
The phosphotyrosine-binding domain of PKCθ interacts with the kinase Zap70 and is required for early TCR signaling.
The nuclear pore complex (NPC) is the sole and selective gateway for transport, its dysfunction has been associated with many diseases. metazoan NPC subcomplex RanBP2, which consists of RanBP2 (Nup358), RanGAP1-SUMO1, Ubc9, regulates assembly function NPC. roles immune signaling in regulation remain poorly understood. Here, we show that human murine T cells, following T-cell receptor (TCR ) stimulation, protein kinase C-θ (PKC-θ) directly phosphorylates RanGAP1 to facilitate import and,...