A5020599499- Venous Thromboembolism Diagnosis and Management
- Heparin-Induced Thrombocytopenia and Thrombosis
- Platelet Disorders and Treatments
- Atrial Fibrillation Management and Outcomes
- Erythrocyte Function and Pathophysiology
- Acute Myocardial Infarction Research
- Hemoglobinopathies and Related Disorders
- Venomous Animal Envenomation and Studies
- Rabies epidemiology and control
- Ultrasound in Clinical Applications
- Blood Coagulation and Thrombosis Mechanisms
- Neonatal Health and Biochemistry
- Central Venous Catheters and Hemodialysis
- Forensic Anthropology and Bioarchaeology Studies
- Vascular anomalies and interventions
- Morphological variations and asymmetry
- Cerebral Venous Sinus Thrombosis
- Paleopathology and ancient diseases
- Forensic and Genetic Research
- Complement system in diseases
- Infectious Aortic and Vascular Conditions
- Law, logistics, and international trade
- Biochemical and Structural Characterization
- Credit Risk and Financial Regulations
- Phagocytosis and Immune Regulation
Duke University
2015-2024
Duke University Hospital
2019-2024
Duke Medical Center
2021-2024
Tel Aviv University
2023
Durham University
2023
Janssen (United States)
2017
University of Washington
2017
Harvard University
2017
Stony Brook Medicine
2017
The University of Texas Southwestern Medical Center
2017
Background It may be possible to safely rule out pulmonary embolism (PE) in patients with low pretest probability (PTP) using a higher than standard D-dimer threshold. The YEARS criteria, which include three questions from the Wells PE score identify low-PTP and variable threshold, was recently shown decrease need for imaging by 14% multicenter study Netherlands. However, approach has not been studied United States. Methods This prospective, observational of consecutive adult evaluated 17...
Abstract Potent and selective inhibition of the structurally homologous proteases coagulation poses challenges for drug development. Hematophagous organisms frequently accomplish this by fashioning peptide inhibitors combining exosite active site binding motifs. Inspired biological strategy, we create several EXACT targeting thrombin factor Xa de novo linking EXosite-binding aptamers with small molecule ACTive inhibitors. The aptamer component within inhibitor (1) synergizes enhances potency...
Abstract Background Hospitalization for low‐risk pulmonary embolism ( PE ) is common, expensive, and of questionable benefit. Objective The objective was to determine if patients discharged from the emergency department ED on rivaroxaban require fewer hospital days compared standard care SOC ). Methods Multicenter, open‐label randomized trial in defined by Hestia criteria. Adult subjects were early discharge or . Primary outcome total number initial hours, plus hours hospitalization bleeding...
Introduction Snakebite envenoming (SBE) results in over 500 000 deaths or disabling injuries annually. Varespladib methyl, an oral inhibitor of secretory phospholipase A2, is a nearly ubiquitous component snake venoms. We conducted phase II clinical trial to assess efficacy and safety varespladib methyl patients bitten by venomous snakes. Methods This double-blind, randomised, placebo-controlled enrolled emergency departments India the USA. Patients with SBE were randomly assigned (1:1)...
<h3>Importance</h3> The monoclonal antibody combination of casirivimab and imdevimab reduced viral load, hospitalization, or death when administered as a 1200-mg greater intravenous (IV) dose in phase 3 COVID-19 outpatient study. Subcutaneous (SC) and/or lower IV doses should increase accessibility drug supplies for patients. <h3>Objective</h3> To assess the virologic efficacy across different SC compared with placebo. <h3>Design, Setting, Participants</h3> This 2, randomized, double-blind,...
Objectives In patients with suspected venous thromboembolism (VTE), the D-dimer assay is commonly utilized as part of workup. The primarily used to determine whether proceed radiographic imaging. We compared levels in having VTE. hypothesized that higher values predict a likelihood subsequent VTE diagnosis. Methods conducted secondary analysis multinational, prospective observational study low- intermediate-risk adult presenting emergency department suspicion Demographic and clinical data...
D-dimer is generally considered positive above 0.5 mg/L irrespective of sex. However, women have been shown to be more likely a after controlling for other factors. Thus, differences may exist between males and females using as marker venous thromboembolic (VTE) disease. We hypothesized that the accuracy tests enhanced by appropriate cutoff values reflect sex-related in levels.This research secondary analysis multicenter, international, prospective, observational study adult (18+ years)...
Anti-platelet factor 4 (PF4)/heparin immune complexes that cause heparin-induced thrombocytopenia (HIT) activate complement via the classical pathway. Previous studies have shown alternative pathway of substantially amplifies activation through C3b feedback cycle.
Abstract The transition to bipedal locomotion was a fundamental milestone in human evolution. Consequently, the skeleton underwent substantial morphological adaptations. These adaptations are responsible for many of today’s common physical impairments, including hip fractures. This study aims reveal changes proximal femur, which increase risk intracapsular fractures present-day populations. Our sample includes chimpanzees, early hominins, Homo Neanderthals, as well prehistoric and recent...
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While thrombosis is the leading cause of morbidity and mortality in United States, an understanding its triggers, progression, response to anticoagulant therapy lacking. Intravital fluorescence microscopy has advanced study thrombus formation by providing targeted, multi-color contrast. However, photodegradation fluorophores limits application longitudinal studies (e.g., clot progression and/or dissolution). Fluorescent nanodiamond (FND) a fluorophore which utilizes intrinsic chromogenic...
Diabetic bladder dysfunction is not understood. Previous work suggests that male MetS Ossabaw pigs have stiffer and more contractile detrusor muscle compared with lean pigs. The purpose of the current study was to determine if altered function in gender dependent. Detrusor strips from female maintained on an atherogenic or control diet were mounted at slack length baths. Following equilibration, stimulated supramaximal electrical field stimulation (EFS). relaxation, cycles incremental...